Laktoferyna - mechanizmy dzialania przeciwwirusowego

• Autorzy: Malaczewska J , Rotkiewicz Z. , Siwicki A.K.

Warianty tytułu

EN

Lactoferrin - mechanisms for antiviral activity

• Języki publikacji: PL

Abstrakty

EN

Lactoferrin (LF) is an iron-binding protein from the transferrin family present in mucus secretions such as milk, tears, saliva, seminal and vaginal fluids and also found in several organs and blood. It is well known for having antibacterial, immunomodulatory and anti-inflammatory properties. Lactoferrin is also capable of inhibiting the replication of both DNA- and RNA-viruses. Studies indicate that LF inhibits infection of the host cell by directly binding to virus particles or by binding to target cell molecules that the virus uses as a receptor or co-receptor. Additionally, LF regulates the antiviral response of the immune system through stimulating cells which play an important role during the early phases of viral infection, e.g. natural killer cells, monocytes, macrophages and granulocytes. The use of lactoferrin as an antiviral drug has a promising future, especially in cases of patients with immunosupression.

Słowa kluczowe

PL

dzialanie przeciwwirusowe; laktoferyna; mechanizm dzialania

• Wydawca: -
• Czasopismo: Medycyna Weterynaryjna
• Rocznik: 2006
• Tom: 62
• Numer: 10
• Opis fizyczny: s.1104-1107,bibliogr.

Twórcy

autor

Malaczewska J

• Uniwersytet Warminsko-Mazurski, ul.Oczapowskiego 13, 10-719 Olsztyn

autor

Rotkiewicz Z.

autor

Siwicki A.K.

Bibliografia

• 1.Andersen J. H., Jenssen H., Gutteberg T. J.: Lactoferrin and lactoferricin inhibit Herpes simplex 1 and 2 infection and exhibit synergy when combined with acyclovir. Antivir. Res. 2003, 58, 209-215.
• 2.Andersen J. H., Osbakk S. A., Vorland L. H., Traavik T., Gutteberg T. J.: Lactoferrin and cyclic lactoferricin inhibit the entry of human cytomegalovirus into human fibroblasts. Antivir. Res. 2001, 51, 141-149.
• 3.Arnold D., Di Biase A. M., Marchetti M., Pietrantoni A., Valenti P., Seganti L., Superti F.: Antiadenovirus activity of milk proteins: lactoferrin prevents viral infection. Antivir. Res. 2002, 53, 153-158.
• 4.Beaumont S. L., Maggs D. J., Clarke H. E.: Effects of bovine lactoferrin on in vitro replication of feline herpesvirus. Vet. Ophthalmol. 2003, 6, 245-250.
• 5.Beljaars L., van der Strate B. W. A., Bakker H. I., Reker-Smit C., van Loenen- -Weemaes A., Wiegmans F. C., Harmsen M. C., Molema G., Meijer D. K. F.: Inhibition of cytomegalovirus infection by lactoferrin in vitro and in vivo. Antivir. Res. 2004, 63, 197-208.
• 6.Berkhout B., van Wamel J. L. B., Beljaars L., Meijer D. K. F., Visser S., Floris R.: Characterization of the anti-HIV effects of native lactoferrin and other milk proteins and protein-derived peptides. Antivir. Res. 2002, 55, 341-355.
• 7.Brock J. H.: The physiology of lactoferrin. Biochem. Cell. Biol. 2002, 80, 1-6.
• 8.Drobni P., Näslund J., Evander M.: Lactoferrin inhibits human papillomavirus binding and uptake in vitro. Antivir. Res. 2004, 64, 63-68.
• 9.Farnaud S., Evans R. W.: Lactoferrin a multifunctional protein with antimicrobial properties. Mol. Immunol. 2003, 40, 395-405.
• 10.Hara K., Ikeda M., Saito S., Matsumoto S., Numata K., Kato N., Tanaka K., Sekihara H.: Lactoferrin inhibits hepatitis B virus infection in cultured human hepatocytes. Hepatol. Res. 2002, 24, 228-235.
• 11.Hirashima N., Orito E., Ohba K., Kondo H., Sakamoto T., Matsunaga S., Kato A., Nukaya H., Sakakibara K., Ohno T., Kato H., Sugauchi F., Kato T., Tanaka Y., Ueda R., Mizokami M.: A randomized controlled trial of consensus interferon with or without lactoferrin for chronic hepatitis C patients with genotype 1b and high viral load. Hepatol. Res. 2004, 29, 9-12.
• 12.Ikeda M., Nozaki A., Sugiyama K., Tanaka T., Naganuma A., Tanaka K., Sekihara H., Shimotohno K., Saito M., Kato N.: Characterization of antiviral activity of lactoferrin against hepatitis C wirus infection in human cultured cells. Virus Res. 2000, 66, 51-63.
• 13.Ikeda M., Nozaki A., Sugiyama K., Tanaka T., Tanaka K., Sekihara H., Shimotohno K., Kato N.: Lactoferrin markedly inhibits hepatitis C virus infection in cultured human hepatocytes. Biochem. Bioph. Res. Co. 1998, 245, 549-553.
• 14.Ishii K., Takamura N., Shinohara M., Wakui N., Shin H., Sumino Y., Ohmoto Y., Teraguchi S., Yamauchi K.: Long-term follow-up of chronic hepatitis C patients treated with oral lactoferrin for 12 months. Hepatol. Res. 2003, 25, 226-233.
• 15.Iwasa M., Kaito M., Ikoma J., Takeo M., Imoto I., Adachi Y., Yamauchi K., Koizumi R., Teraguchi S.: Lactoferrin inhibits hepatitis C virus viremia in chronic hepatitis C patients with high viral loads and HCV genotype 1b. Am. J. Gastroenterol. 2002, 97, 766-767.
• 16.Jenssen H., Andersen J. H., Uhlin-Hansen L., Gutteberg T. J., Rekdal Ø.: Anti- -HSV activity of lactoferricin analogues is only partly related to their affinity for heparan sulfate. Antivir. Res. 2004, 61, 101-109.
• 17.Lubashevsky E., Krifucks O., Paz R., Brenner J., Savransky S., Trainin Z., Ungar- -Waron H.: Effect of bovine lactoferrin on a transmissible AIDS-like disease in mice. Comp. Immunol. Microb. 2004, 27, 181-189.
• 18.Marchetti M., Longhi C., Conte M. P., Pisani S., Valenti P., Seganti L.: Lactoferrin inhibits herpes simplex virus type 1 adsorption to Vero cells. Antivir. Res. 1996, 29, 221-231.
• 19.Marchetti M., Superti F., Ammendolia M. G., Rossi P., Valenti P., Seganti L.: Inhibition of polivirus type 1 infection by iron-, manganese- and zinc-saturated lactoferrin. Med. Microbiol. Immun. 1999, 187, 199-204.
• 20.Marchetti M., Trybala E., Superti F., Johansson M., Bergström T.: Inhibition of herpes simplex virus infection by lactoferrin is dependent on interference with the virus binding to glycosaminoglycans. Virology 2004, 318, 405-413.
• 21.McCann K. B., Lee A., Wan J., Roginsky H., Coventry M. J.: The effect of bovine lactoferrin and lactoferricin B on the ability of feline calicivirus (a norovirus surogate) and poliovirus to infect cell cultutures. J. Appl. Microbiol. 2003, 95, 1026-1033.
• 22.Murphy M. E., Kariwa H., Mizutani T., Yoshimatsu K., Arikawa J., Takashima I.: In vitro antiviral activity of lactoferrin and ribavirin upon hantavirus. Arch. Virol. 2000, 145, 1571-1582.
• 23.Puddu P., Borghi P., Gessani S., Valenti P., Belardelli F., Seganti L.: Antiviral effect of bovine lactoferrin saturated with metal ions on early steps of human immunodeficiency virus type 1 infection. Int. J. Biochem. Cell B. 1998, 30, 1055-1063.
• 24.Siciliano R., Rega B., Marchetti M., Seganti L., Antonini G., Valenti P.: Bovine lactoferrin peptidic fragments involved in inhibition of herpes simplex virus type 1 infection. Biochem. Bioph. Res. Co. 1999, 264, 19-23.
• 25.Strate B. W. A. van der, Beljaars L., Molema G., Harmsen M. C., Meijer D. K. F.: Antiviral activities of lactoferrin. Antivir. Res. 2001, 52, 225-239.
• 26.Strate B. W. A. van der, De Boer F. M., Bakker H. I., Meijer D. K. F., Molema G., Harmsen M. C.: Synergy of bovine lactoferrin with the anti-cytomegalovirus drug cidofovir in vitro. Antivir. Res. 2003, 58, 159-165.
• 27.Superti F., Ammendolia M. G., Valenti P., Seganti L.: Antirotaviral activity of milk proteins: lactoferrin prevents rotavirus infection in the enterocyte-like cell line HT-29. Med. Microbiol. Immun. 1997, 186, 83-91.
• 28.Superti F., Siciliano R., Rega B., Giansanti F., Valenti P., Antonini G.: Involvement of bovine lactoferrin metal saturation, sialic acid and protein fragments in the inhibition of rotavirus infection. Biochimica et Biophysica Acta 2001, 1528, 107-115.
• 29.Swart P. J., Harmsen M. C., de Bethune M. P., Pauwels R., De Clercq E., The T. H., Meijer D. K. F.: Antiviral effects of plasma and milk proteins: lactoferrin shows potent antiviral activity on both HIV and HCMV replication in vitro in the same concentration range. Antivir. Res. 1996, 30, A 35.
• 30.Swart P. J., Kuipers M. E., Smit C., De Clercq E., Huisman H., Meijer D. K. F.: Antiviral effect of milk proteins: acylation results in polyanionic compounds with potent activity against HIV type I and II in vitro. Antivir. Res. 1996, 30, A 41.
• 31.Tanaka T., Nakatani S., Xuan X., Kumura H., Igarashi I., Shimazaki K.: Antiviral activity of lactoferrin against canine herpesvirus. Antivir. Res. 2003, 60, 193-199.
• 32.Tomita M., Wakabayashi H., Yamauchi K., Teraguchi S., Hayasawa H.: Bovine lactoferrin and lactoferricin derived from milk: production and applications. Biochem. Cell Biol. 2002, 80, 109-112.