Kinetics of a nucleoside release from lactide-caprolactone and lactide-glycolide polymers in vitro

• Autorzy: Kryczka T. , Grieb P. , Bero M. , Kasperczyk J. , Dobrzynski P.
• Języki publikacji: EN

Abstrakty

EN

We assessed the rate of release of a model nucleoside (adenosine, 5%, w/w) from nine different lactide-glycolide or lactide-caprolactone polymers. The polymer discs were eluted every second day with an artificial cerebrospinal fluid at the elution rate roughly approximating the brain extracellular fluid formation rate. Adenosine in eluate samples was assayed by HPLC. Three polymers exhibited a relatively constant release of adenosine for over four weeks, resulting in micromolar concentrations of nucleoside in the eluate. This points to the neccessity of further development of polymers of this types as intracerebral nucleoside delivery systems for local treatment of brain tumors.

Słowa kluczowe

EN

brain cancer; biodegradable polymer; adenosine; glioma; malignant tumour; nucleoside release; kinetics; in vitro; blood brain barrier; cytostatic drug

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2000
• Tom: 47
• Numer: 1
• Opis fizyczny: p.59-64,fig.

Twórcy

autor

Kryczka T.

• Polish Academy of Sciences, 02-106 Warsaw, Poland

autor

Grieb P.

autor

Bero M.

autor

Kasperczyk J.

autor

Dobrzynski P.

Bibliografia

• 1. Black, P. (1998) Management of malignant glioma: Role of surgery in relation to multimodality therapy. J. Neurovir. 4, 227- 236.
• 2. Vecht, C.J. (1998) Clinical management of brain metastasis. J. Neurol. 245, 127-131.
• 3. Matyja, E., Grieb, P., Ryba, M., Jagielski, J. & Mossakowski, M.J. (1996) Mitochondrial damage following exposure of organotypic cultures of human malignant gliomas to 2-chloro- and 2-bromo-2'-deoxyadenosine. Folia Neuropathol. 34, 31-39.
• 4. Grieb, P., Skierski, J., Jagielski, J., Ryba, M. & Mossakowski, M.J. (1995) DNA protein flow cytometry of dissociated cultures of human anaplastic gliomas. Pattern of proliferation and differentiation, and the effect of a new cytostatic drug cladribine (2-CdA) Folia Neuropathol. 33, 145-152.
• 5. Liliemark, J. (1997) The clinical pharmacokinetics of cladrabine. Clin. Pharmacokinet. 32, 120-131.
• 6. Rajkumar, S.V., Burch, P.A., Nair, S., Dinapoli, R.P., Scheithauer, B., O'Fallon, J.R., Etzell, P.S., Leitch, J.M., Morton, R.F. & Marks, R.S. (1999) Phase II North Central Cancer Treatment Group study of 2-chlorodeoxyadenosine in patients with recurrent glioma. Am. J. Clin. Oncol. 22, 168-171.
• 7. Olivi, A., Ewend, M.G., Utsuki, T., Tyler, B., Domb, A.J., Brat, D.J. & Brem, H. (1996) Interstitial delivery of carboplatin via biodegradable polymers is effective against experimental glioma in the rat. Cancer Chemother. Pharmacol. 39, 90-96.
• 8. Ewend, M.G., Williams, J.A., Tabassi, K., Tyler, B.M., Babel, K.M., Anderson, R.C., Pinn, M.L., Brat, D.J. & Brem, H. (1996) Local delivery of chemotherapy and concurrent external beam radiotherapy prolongs survival in metastatic brain tumor models. Cancer Res. 56, 5217-5223.
• 9. Bero, M., Dobrzynski, P., Kasperczyk, J. (1999) Application of zirconium(IV) acetylacetonate to the copolymerization of glycolide with -caprolactone and lactide. Polymer Bull. 42, 131-139.
• 10. Bero, M., Dobrzynski, P. & Kasperczyk, J. (1998) Polish Patent: Sposob wytwarzania lekkich, trudnopalnych kompozytow polimerowych P-329 628 (in Polish).
• 11. Grieb, P., Jagielski, J., Ryba, M., Bero, M., Sawicki, J. & Walski, M. (1994) Biocompatibility of a block copolymer of -caprolactone and lactide with brain tissues. 2nd Joint Polish-German Neurosurgical Symposium, Olsztyn, Abstracts, p. 89.
• 12. Milhorat, T.H. (1969) Choroid plexus and cerebrospinal fluid production. Science 166, 1514-1516.
• 13. Williams, J.A., Dillehay, L.E., Tabassi, K., Sipos, E., Fahlman, C. & Brehm, H. (1997) Implantable biodegradable polymers for IUdR radiosensitization of experimental human malignant glioma. J. Neuro-Oncol. 32, 181-192.
• 14. Doiron, A., Yapp, D.T., Olivares, M., Zhu, J.X. & Lehnert, S. (1999) Tumor radiosensitization by sustained intratumoral release of bromodeoxyuridine. Cancer Res. 59, 3677-3681.
• 15. Menei, P., Venier, M.C., Gamelin, E., Saint-Andre, J.P., Hayek, G., Jadaud, E., Fournier, D., Mercier, P., Guy, G. & Benoit, J.P. (1999) Local and sustained delivery of 5-fluorouracil from biodegradable microspheres for the radiosensitization of glioblastoma: A pilot study. Cancer 86, 197-199.