Mycobacterium bovis BCG mycobacteria - new application

• Autorzy: Kowalewicz-Kulbat M , Pestel J. , Biet F. , Locht C. , Tonnel A.B. , Druszczynska M. , Rudnicka W.
• Języki publikacji: EN

Abstrakty

EN

The polarized response of T helper-2 (Th2) lymphocytes to an allergen is considered to be the main cause of the pathogenesis of asthma. In this study, we asked a question whether M. bovis BCG mycobacteria which are known for the preferential stimulation of T helper-1 (Th1) immunity, diminish the effector functions of Th2 cells from allergic patients upon stimulation with a common house dust mite Der p-1 allergen. Our results allow a positive answer to this question. We demonstrate that BCG modulates the dendritic cell-dependent allergen presentation process and switches naive T lymphocytes towards an anti-allergic Th1 profile.

Słowa kluczowe

EN

human disease; pathogenesis; asthma; Mycobacterium bovis; cytokine; house dust; allergy; mite; microbiology; allergen

• Wydawca: -
• Czasopismo: Polish Journal of Microbiology
• Rocznik: 2006
• Tom: 55
• Numer: 1
• Opis fizyczny: p.13-17,fig.,ref.

Twórcy

autor

Kowalewicz-Kulbat M

• University of Lodz, Banacha 12/16, 90-237 Lodz, Poland

autor

Pestel J.

autor

Biet F.

autor

Locht C.

autor

Tonnel A.B.

autor

Druszczynska M.

autor

Rudnicka W.

Bibliografia

• Geha R.S. 2003. Allergy and hypersensitivity. Nature versus nurture in allergy and hypersensitivity. Curr. Opin. Immunol. 15: 603-608.
• Grakoui A., S.K. Bromley, C. Sumen, M.M. Davis, A.S. Shaw, P.M. Allen and M.L. Dustin. 1999. The immunological synapse: a molecular machine controlling T cell activation. Science 285: 221-227.
• Griffin J.F., C.G. Mackintosh, L. Slobbe, A.J.Thomson and G.S. Buchan. 1999. Vaccine protocols to optimise the protective efficacy of BCG. Tuber. Lung Dis. 79: 135-143.
• Herr H.W. 2005. Restaging transurethal resection of high risk superficial bladder cancer improves the initial response to Bacille Calmette-Guérin therapy. J. Urol. 174: 2134-2137.
• Hoft D.F., C. Leonardi, T. Milligan, G.T. Nahass, B. Kemp, S. Cook, J. Tennant and M. Carey. 1999. Clinical reactogenicity of intradermal Bacille Calmette-Guérin vaccination. Clin. Infect. Dis. 28: 785-790.
• Huebner R.E. 1996. BCG vaccination in the control of tuberculosis. Curr. Top. Microbiol. Immunol. 215: 263-282.
• Jacobelli J., P.G. Andres, J. Boisvert and M.F. Krummel. 2004. New views of the immunological synapse: variations in asembly and function. Curr. Opin. Immunol. 16: 345-352.
• Kaufmann S.H.E. 2005. Rational vaccine design against tuberculosis. Vaccine Congress. New Approches to Vaccine Development. From the bench to the field. 8-10 September 2005, Berlin, Germany.
• Lallemant-LeCoeur S., M. Lallemant, D. Cheynier, S. Nzingoula, J. Drucker and B. Larouze. 1991. Bacillus Calmette-Guerin immunization in infants born to HIV-1-seropositive mothers. AIDS 5: 195-199.
• Lambrecht B.N. and H. Hammad. 2003. The other cells in asthma: dendritic cell and epithelial cell crosstalk. Curr. Opin. Pulm. Med. 9: 34-41.
• Marchant A., T. Goetghebuer, O. M.O, I. Wolfe, S.J. Ceesay, D. De Groote, T. Corrah, S. Bennett, J. Wheeler, K. Huygen, P. Aaby, K.P. McAdam and M. Newport. 1999. Newborns develop a Th1-type immune response to Mycobacterium bovis Bacillus Calmette-Guérin vaccination. J. Immunol. 163: 2249-2255.
• Pochard P., H. Hammad, C. Ratajczak, A-S. Charbonnier-Hatzfeld, N. Just, A-B. Tonnel and J. Pestel. 2005. Direct regulatory immune activity of lactic acid bacteria on Der p-1 pulsed dendritic cells from allergic patients. J. Allergy Clin. Immunol. 116: 198-204.
• Romagnani S. 2000. The role of lymphocytes in allergic disease. J. Allergy Clin. Immunol. 105: 399-408.
• Williams A., A. Davies, P.D. Marsh, M.A. Chambers and R.G. Hewinson. 2000. Comparison of the protective efficacy of Bacille Calmette-Guerin vaccination against aerosol challenge with Mycobacterium tuberculosis and Mycobacterium bovis. Clin. Infect. Dis. 30, Suppl. 3: S299-301.