Induced sputum eosinophils, bronchial reactivity, and cough sensitivity in subjects with allergic rhinitis

• Autorzy: Tatar M. , Petriskova J. , Zucha J. , Pecova R. , Hutka Z. , Raffajova J. , Brozmanova M.
• Języki publikacji: EN

Abstrakty

EN

Some patients with allergic rhinitis and no clinical evidence of asthma exhibit bronchial hyperresponsiveness. In the present study, induced sputum and acetylcholine and capsaicin challenges were assessed in four groups of adult subjects: allergic rhinitis (AR), allergic rhinitis with lower airway symptoms (ARLA), mild stable asthma (BA), and healthy volunteers (C) to correlate lower airway inflammatory markers with bronchial and cough reactivity. Patients with AR (n = 13) and ARLA (n = 11) did not take any anti-inflammatory drugs. Those with BA (n = 9) used inhaled corticosteroids and C (n = 10) were respiratory symptoms free. The patients underwent capsaicin cough challenge and sputum induction with hypertonic saline during the first visit, and acetylcholine bronchial challenge on a separate day. We found that the percentage of eosinophils in induced sputum was significantly higher in patients with AR, ARLA, and BA than in C 14.5 ±1.8(SE) vs. 13.5 ±2.9 vs. 13.9 ±4.0 vs. 3.6 ±0.8 %, respectively (P=0.012). In contrast, acetylcholine PD20 in patients with AR, ARLA, and BA was significantly lower than in C 5.6 ±0.9 vs. 4.1 ±0.4 vs. 2.8 ±0.4 vs. 12.9 ±2.7 mg, respectively (P=0.0001). Neither the eosinophil percentage nor PD20, nor cough sensitivity appreciably differed across the patients groups. Sputum eosinophils correlated significantly with the acetylcholine PD20 (r=0.37, P=0.016). We conclude that eosinophilic inflammation of lower airways and increased bronchial reactivity were present in adult patients with allergic rhinitis.

Słowa kluczowe

EN

sputum; acetylcholine; induced sputum; eosinophil; airway hyperresponsiveness; allergic rhinitis; bronchial reactivity; capsaicin cough sensitivity; asthma; patient; cough

• Wydawca: -
• Czasopismo: Journal of Physiology and Pharmacology. Supplement
• Rocznik: 2005
• Tom: 56
• Numer: 4
• Opis fizyczny: p.227-236,fig.,ref.

Twórcy

autor

Tatar M.

• Jessenius School of Medicine, Comenius University, 26 Sklabinska St., 037 53 Martin, Slovakia

autor

Petriskova J.

autor

Zucha J.

autor

Pecova R.

autor

Hutka Z.

autor

Raffajova J.

autor

Brozmanova M.