Pierwsze badania peroksydoksyn - nowej rodziny antyoksydantow u pasozytow

• Autorzy: Boczon K
• Języki publikacji: PL

Abstrakty

EN

The data from the first investigatiom of a new antioxidants family – peroxidoxins - in parasites. The properties and mechanism of action of a new family of antioxidants-peroxidoxins have been described. The properties of parasitic peroxidoxins in some helminths and protozoans discovered as a result of genom sequencing and expressed sequence tag (EST) project have been presented. The data described untill now from a number of studies with parasites indicate that the family of peroxidoxins, very important for the host-parasite interactions may be in future a potential candidate vaccine molecules in some systems.

Słowa kluczowe

PL

reaktywne formy tlenu; parazytologia; stres oksydacyjny; peroksydoksyny; pasozyty; przeciwutleniacze; wolne rodniki

• Wydawca: -
• Czasopismo: Wiadomości Parazytologiczne
• Rocznik: 2002
• Tom: 48
• Numer: 1
• Opis fizyczny: s.3-10,rys.,tab.,bibliogr.

Twórcy

autor

Boczon K

• Akademia Medyczna, ul.Fredry 10, 61-701 Poznan

Bibliografia

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• Chae H.Z., Robinson L.B., Poole L.B., Church G., Starz G. 1994. Cloning and sequencing of thiol-specific antioxidant from mammalian brain: alkyl hydroperoxide reductase and thiolspecific antioxidant define a large family of antioxidant enzymes. Proceedings of National Academy of Sciences U.S.A. 91: 7017-7021.
• El Sayed N.M.A., Alarcon C.M., Beck J.C., Sheffield V.C., Donelson J.E. 1995. CDNA expressed sequence tags of Trypanosoma brucei rhodesiense provide new insights into the biology of the parasite. Molecular and Biochemical Parasitology 73: 75-90.
• Flores S.B.M., Reed S.L., Ravdin J.l., Torian B.E. 1993. Serologic reactivity to purified recombinant and native 29kDa peripheral membrane protein of pathogenic Entamoeba histolytica. Journal of Clinical Microbiology 34: 1403- 1407.
• Mc Gonigle S., J.P. Dalton & James E.R. 1998. Peroxidoxins: A new antioxidant family. Parasitology Today 14: 139-145.
• Netto I.E.S, Chae H.Z„ Won Kang G.S„ Goo Rhee S., Stadtman E.R. 1996. Removal of hydrogen peroxide by thiol-specific antioxidant enzyme (TSA) is involved with its antioxidant properties. Journal of Biological Chemistry 271: 15315-15321.
• Reed S.L., Flores B.M., Batzer M.A., Stein M.A., Stroeher V.J., Carltone J.E., Diedrich O.J., Toriao B.E. 1992. Molecular and cellular characterization of the 29kDa peripheral membraoe protein of Entamoeba histolytica: differentiation between pathogenic and nonpathogenic isolates. Infections Immunity 60: 542-549.
• Soong G.J.G.B, Toriao B.E., Abd-Alla MD., Jackson T.F.H.G., Gatharim V., Ravdin J.I. 1995. Protection of gerbils from amebic liver abscess by immunization with recombinant Entamoena histolytica 29kDa antigen. Infections Immunity 63: 472-477.
• Tetaud D.E., Fairlamb A.H. 1998. Cloning, expression and reconstitution of the trypaoothionedependent peroxidase system of Crithidia fasciculata. Molecular and Biochemical Parasitology 96: 111-123.