Anticoagulative effect of pepsin

• Autorzy: Gacko M. , Roszkowska-Jakimiec W. , Jasielczuk J.
• Języki publikacji: EN

Abstrakty

EN

Anticoagulative effect of pepsin is observed in vitro when its concentration is 36 μM and higher. This effect is due to inhibition of fibrin monomer polimerization. Protamine abolishes anticoagulative effect of pepsin. Pepsin does not influence platelet aggregation induced by ADP and collagen.

Słowa kluczowe

EN

prothrombin; glycosaminoglycan; polymerization; adenosine 5'-diphosphate; heparin; pepsin; collagen; fibrinolytic effect

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 1999
• Tom: 46
• Numer: 3
• Opis fizyczny: p.717-720

Twórcy

autor

Gacko M.

• Medical Academy, P.O.Box 24, 15-230 Bialystok 8, Poland

autor

Roszkowska-Jakimiec W.

autor

Jasielczuk J.

Bibliografia

• 1. Bourin, M.C. & Lindahl, U. (1993) Glyco- saminoglycan8 and the regulation of blood co­agulation. Biochem. J. 289, 313-330.
• 2. Undas, A. & Gajewski, P. (1998) Role of heparinoids in treatment of vascular diseases. Pol Arch. Med. Wewn. 99, 430-435 (in Pol-' ish).
• 3. Perlman, G.E. (1970) Porcine pepsinogen and pepsin; in Structure - Function Relationship of Proteolytic Rnzymea (Desnuelle. P.. Neurath, H. & Ottesen, M., eds.) pp. 261-270, Munks- gaard, Copenhagen.
• 4. Lottenberg, R., Hall, J.A., Fenton, J.W. & Jackson, C.M. (1982) The action of thrombin on peptide p-nitroanilide substrates: Hydroly­sis of Tos-Gly-Pro-Arg*pNA and D-Phe-Pip-Arg- pNA by human a- and y- and bovine a- and /krombin. Thrombos. Res. 28, 313-322.
• 5. Born, G.V.R. (1963) Quantitative investiga­tion into aggregation of blood platelets. J. Physiol 168, 178-195.
• 6. Roszkowska-Jakimiec, W., Fouad, Khamis A., Gacko, M. & Worowska, A. (1996) Properties of pepsin as a polyanion protein. Part I: Com­plexes of pepsin with protamine. Bromat. Chem. Toksykol 29, 381-386 (in Polish).
• 7. Lipiński, B., Węgrzynowicz, Z., Budzyński, A.Z., Kopeć, M., Latałło, Z.S. & Kowalski, E. (1967) Soluble unclotable complexes formed in the presence of fibrinogen degradation products (FDP) during the fibrinogen-fibrin conversion and their potential significance in pathology. Thrombos. Diathes. Haemorrhag. 17, 65-69.
• 8. Brezniak, D.V., Moon, D.G., Beaver, J.A. & Fenton, J.W. (1994) Haemoglobin inhibition of fibrin polymerization and clotting. Blood CoagulaU FibrinoL 5, 139-143.
• 9. Carr, M.E., Cromartie, R. & Gabriel, D.A. (1989) Effect of homopoly(L-amino acids) on fi­brin assembly: Role of charge and molecular weight. Biochemistry 28, 1384-1388.
• 10. Vellacott, K.D., Drenfield, M.W., Atkinson, M. & Langman, M.J.S. (1982) Comparison of sur­gical and medical management of bleeding peptic ulcer. Br. Med. J. 284, 548-550.
• 11. Sajewicz, Z., Poniewierka, E., Lubczyńska-Ko- walska. W., Szmigielski. R. & Bitter. J. (1996) Influence of gasrtic juice and sucralfate on fibrinolysis. Ter. Leki 24,142-144 (in Polish).
• 12. Green, F.W., Kaplan, M.M., Curtis, L.E. & Le- vine, I.H. (1978) Effect of acid and pepsin on blood coagulation and platelet aggregation. A possible contribution to prolonged gastroduo- denal mucosal hemorrhage. Gastroenterology 14, 38-43.
• 13. Prokopowicz, J., Gabryelewicz, A., Wołoso- wicz, N., Szałaj, W. & Puchalski, Z. (1975) Pe­ripheral and gastric fibrinolysis in patients with gastric carcinoma. Z. Exp. Chirurg. 8, 309-312.
• 14. O'Brien, T.E., Handley, H. & Irving, M.H. (1979) Fibrinolytic activity in gastric venous blood. A comparison between normal and dis­eased stomach. Gastroenterology 76,509-514.
• 15. Samloff, I.M. (1982) Pepsinogen I and II: Purification from gastric mucosa and radio­immunoassay in serum. Gastroenterology 82, 26-33.
• 16. Taylor, W.H. (1986) Advances in the biochem­istry and pathophysiology of pepsin 1. Z. Med. Lab. Diagn. 27, 115-120.