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2000 | 05 | 3 |

Tytuł artykułu

A quaternary ammonium salt as an inhibitor of plasma membrane Hplus-ATPase in yeast Saccharomyces cerevisiae

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
A quaternary ammonium salt, dodecyloxycarboxymethyl N, N, N - trimethyl ammonium chloride (IM), inhibits glucose-stimulated proton extrusion in yeast cells. The IM-resistant mutant (IMR) and pmal mutant are less sensitive to this inhibition. The inhibition of amino acids uptake by IM depends on repressed or derepressed conditions. IM treatment of yeast cells leads to a change of internal pH in a quinacrine fluorescence test.

Wydawca

-

Rocznik

Tom

05

Numer

3

Opis fizyczny

p.315-324,fig.

Twórcy

autor
  • University of Wroclaw, Przybyszewskiego 65-7, 51-148 Wroclaw, Poland
autor

Bibliografia

  • 1. Domagk, G. Eine neue Klasse von disinfektions-mitteln. Dtsch. Med. Wochenschr. 61 (1935) 829-832.
  • 2. Piątkowski, J. Auxotrophy and sensitivity of microorganism on quaternary ammonium salts (in Polish). PhD. Thesis, University of Wrocław (1993)
  • 3. Lachowicz, T. M., Witkowska, R., Obłąk, E. Amino Acid Auxotrophy Increases Sensitivity of Saccharomyces cerevisiae to a Quaternary Ammonium Salt IM. Acta Microbiol. Polon. 39 (1990) 157-162.
  • 4. Lachowicz, T. M., Obłąk, E., Piątkowski, J. Auxotrophy Stimulated Sensitivity to Quaternary Ammonium Salts and Its Relation to Active Transport in Yeast. Bul. Pol. Acad. Sci. 40 (1992) 173-182.
  • 5. Goffeau, A., Slayman, C., The proton-translocating ATPase of the fungal plasma membrane. Biochim. Biophys. Acta 639 (1981) 197-223.
  • 6. Obłąk, E., Ułaszewski, S., Lachowicz, T. M. Mutants of Saccharomyces cerevisiae resistant to a quaternary ammonium salt. Acta Microbiol. Polon. 37 (1988) 261-269.
  • 7. Obłąk, E., Ułaszewski, S., Morawiecki, A., Witkowska, R., Majcher, K., Lachowicz, T. M. Quaternary ammonium salt resistant mutants in Yeast Saccharomyces cerevisiae. Yeast 5 (Special Issue) (1989) S273-S278.
  • 8. Ułaszewski, S., Balzi, E., Goffeau, A. Genetic and molecular mapping of the pmal mutation conferring vanadate resistance to the plasma membrane ATPase from Saccharomyces cerevisiae. Mol. Gen. Genet. 207 (1987) 38-46.
  • 9. Dufour, J. P., Goffeau, A. Solubilization by Lysolecithin and Purification of the Plasma Membrana ATPase of the Yeast Schizosaccharomyces pombe. J. Biol. Chem. 253 (1978) 7026-7032.
  • 10. Ułaszewski, S. Interactions between the gene products of pma1 encoding plasma membrane H+-ATPase, and pdr1 controlling multiple drug resistance in Saccharomyces cerevisiae. Acta Biochim. Polon. 40 (1993) 487-496.
  • 11. Sigler, K., Knotkova, A., Kotyk, A. Factors governing substrate induced generation and extrusion of protons in the yeast Saccharomyces cerevisiae. Biochim. Biophys. Acta, 643 (1981) 572-582.
  • 12. Kotyk, A. Mechanisms of extracellular acidification by yeast. J. Biophys. 3 (1993) 17-26.
  • 13. Preston, R. A., Murhpy, R. F., Jones, E. W. Assay of vacuolar pH in yeast and identification of acidification - defective mutans. Proc. Nat. Acad. Sci. USA 86 (1989) 7027-7031.
  • 14. Umemoto, N., Yoshihisa, T., Hirata, R., Anraku, Y. Roles of the vam 3 gene produkt, subunit c of the vacuolar membrane H+-ATPase on vacuolar acidification and protein transport. J. Biol. Chem. 265 (1990) 18447- 18453.
  • 15. Kotyk, A., Rihova, L. Energy requirement for amino acid uptake in S. cerevisiae. Folia Microbiol. 17 (1972) 353-356.
  • 16. Bray, G. A. A Simple Efficient Liquid Scintillation Method for Counting Aqueous Solutions in a Liquid Scintillation Counten. Annal. Biochim. 1 (1960) 279.
  • 17. Obłąk, E., Lachowicz, T. M., Witek, S. DL-leucine transport in a Saccharomyces cerevisiae mutant resistant to quaternary ammonium salta. Folia Microbiol. 41 (1996) 116-118.
  • 18. Witek, S., Goffeau, A., Nader, J., Łuczyński, J., Lachowicz, T. M., Kuta, B., Obłąk, E. Lysosomotropic Aminoesters Act as H+-ATPase Inhibitors in Yeast. Folia Microbiol. 42 (1997) 252-254.

Typ dokumentu

Bibliografia

Identyfikatory

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