The vasopressin and oxytocin neurohypophysial content as influenced by bleeding or dehydration: effect of cholecystokinin octapeptide

• Autorzy: Lewandowska A , Glowacka A. , Guzek J.W.
• Języki publikacji: EN

Abstrakty

EN

The effect of CCK-8 (50 ng, i. c. v.) on the neurohypophysial vasopressin and oxytocin storage was estimated in haemorrhaged (1 ml per 100 g b. w.) male Wistar rats. In another experimental series rats dehydrated for three days were given CCK-8 in a daily i. c. v. dose of 50 ng. The neurohypophysial vasopressin and oxytocin content was bioassayed by pressor effect following Dekański or milk- ejection activity in vitro following van Dongen and Hays, respectively. The decrease of neurohypophysial vasopressin and oxytocin content, brought about by dehydration, was significantly less marked in animals treated with CCK-8. The depletion of neurohypophysial vasopressin and oxytocin content in haemorrhaged animals could be completely inhibited by earlier i. c. v. administration of CCK-8. It is suggested that hypothalamic cholecystokinin may serve as a modulator of neurohypophysial function.

Słowa kluczowe

EN

dehydration; vasopressin; cholecystokinin octapeptide; neurohypophysis; hemorrhage; oxytocin; rat; bleeding

• Wydawca: -
• Czasopismo: Journal of Physiology and Pharmacology
• Rocznik: 1992
• Tom: 43
• Numer: 2
• Opis fizyczny: p.153-163,fig.

Twórcy

autor

Lewandowska A

• School of Medicine, 90-136 Lodz, Narutowicza 60, Poland

autor

Glowacka A.

autor

Guzek J.W.

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