Interakcje fluorochinolonow z jonami metali i ich znaczenie kliniczne

• Autorzy: Jakubowski P , Jaroszewski J.J.

Warianty tytułu

EN

Interactions of fluoroquinolones with ions of metals and their clinical significance

• Języki publikacji: PL

Abstrakty

EN

Fluoroquinolones are a group of antimicrobial agents which are widely used in human and veterinary medicine. These drugs may cause interactions with other compounds. The paper describes the latest views concerning interactions between fluoroquinolones and metal cations. Simultaneous administration of fluoroquinolones with 2- and 3-valent cations causes a significant decrease in the bioavailability of these drugs due to the effect of chelating cations by carboxylate and the carbonyl group of fluoroquinolone. These interactions may result in an inefficient antimicrobial therapy and, in order to prevent this occurring, spaced dosing of fluoroquinolones and a formulation containing metal cations is recommended.

Słowa kluczowe

PL

fluorochinolony; interakcje; kationy; znaczenie kliniczne; jony metali

• Wydawca: -
• Czasopismo: Medycyna Weterynaryjna
• Rocznik: 2006
• Tom: 62
• Numer: 10
• Opis fizyczny: s.1120-1122,rys.,bibliogr.

Twórcy

autor

Jakubowski P

• Uniwersytet Warminsko-Mazurski, ul.Oczapowskiego 13, 10-718 Olsztyn

autor

Jaroszewski J.J.

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