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2008 | 57 | 3 |

Tytuł artykułu

Evaluation of antibacterial activity of synthetic aliphatic and aromatic monoacylglycerols

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
The antibacterial activity of synthetic aliphatic and aromatic monoacylglycerols (MAGs) was studied against two human pathogens: Staphylococcus aureus and Esherichia coll. The active compounds inhibited selectively S. aureus. The most active compounds amongst them were those with medium size aliphatic chain and aromatic MAGs with electron withdrawing substituents at the aryl ring. The introduction of one or two-carbon spacer between the aryl ring and the carboxylic function did not influence antibacterial effectiveness.

Wydawca

-

Rocznik

Tom

57

Numer

3

Opis fizyczny

p.261-265,fig.,ref.

Twórcy

autor
  • Bulgarian Academy of Sciences, Acad.G.Bonchev Str.Bl.9, Sofia 1113, Bulgaria
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autor

Bibliografia

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  • Batovska D., S. Tsubota, Y. Kato, Y. Asano and M. Ubukata. 2004. Lipase-mediated desymmetrization of glycerol with aromatic and aliphatic anhydrides. Tetrahedron Asymm. 15: 3551-3559.
  • Bergsson G., J. Arnfinnsson, O. Steingrimsson and H. Thormar. 2001. In vitro killing of Candida albicans by fatty acids and monoglycerides. Antimicrob. Agents Chemother. 45: 3209-3212.
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  • Padrón J., R. Carrasco and R. Pellón. 2002. Molecular descriptor based on a molar refractivity partition using Randic-type graph-theoretical invariant. J. Pharm. Pharmaceut. Sci. 5: 258-266.
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  • Ruzin A. and R. Novick. 1998. Glycerol monolaurate inhibits induction of vancomycin resistance in Enterococcus faecalis. J. Bacteriol. 180: 182-185.
  • Spooner F. and G. Sykes G. 1979. Laboratory assessment of antibacterial activity, pp 216-217. In: J.R. Norris and D.W. Ribbons (eds), Methods in Microbiology 7B. Academic Press, London.
  • Thormar H., C. Isaacs, H. Brown, M. Barshatzky and T. Pessolano. 1987. Inactivation of enveloped viruses and killing of cells by fatty acids and monoglycerides. Antimicrob. Agents Chemother. 31: 27-31.
  • Vetter S. and P. Schlievert. 2005. Glycerol monolaurate inhibits virulence factor production in Bacillus anthracis. Antimicrob. Agents Chemother. 49: 1302-1305.
  • Web site. 2000. http://www.life.umd.edu/classroom/bsci424/Lab MaterialsMethods/BrothTubeMIC.htm.

Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

bwmeta1.element.agro-article-81751ae5-f1f3-4557-a148-3f0700271312
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