Nuclear receptors, their coactivators and modulation of transcription

• Autorzy: Manteuffel-Cymborowska M.
• Języki publikacji: EN

Abstrakty

EN

Nuclear receptors arc ligand-dependent transcription factors which can also be ac­tivated in the absence of their lipophilic ligands by signaling substances acting on cell membrane receptors. This ligand-independent activation indicates the impor­tance of nuclear receptor phosphorylation for their function. Nuclear receptor- mediated transcription of target genes is further increased by interactions with re­cruited coactivators forming a novel family of nuclear proteins. CBP/p300, a coacti­vator of different classes of transcription factors, including the tumor suppressor protein p53, plays a special role acting as a bridging protein between inducible tran­scription factors and the basal transcription apparatus, and as an integrator of di­verse signaling pathways. Coactivators of nuclear receptors and associated proteins forming a multicomponent complex have an intrinsic histone acetylase activity in contrast to nuclear receptor and heterodimer Mad-Max corepressors, which recruit histone deacetylase. Similarly the Rb protein interacts with histone deacetylase to re­press transcription of cell cycle regulatory genes. Targeted histone acetylation/dca- cetylation results in remodeling of chromatin structure and correlates with activa­tion/repression of transcription. Recent data point to the important role of coactiva­tor proteins associated with inducible transcription factors in transcription regula­tion, and in the integration of multiple signal transduction pathways within the nu­cleus.

Słowa kluczowe

EN

transcription regulation; chromatin; histone acetylase; nuclear receptor; histone deacetylase; steroid receptor coactivator

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 1999
• Tom: 46
• Numer: 1
• Opis fizyczny: p.77-89,fig.

Twórcy

autor

Manteuffel-Cymborowska M.

• M.Nencki Institute of Experimental Biology, L.Pasteura 3, 02-093 Warsaw, Poland

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