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2007 | 63 | 02 |

Tytuł artykułu

Laktoferyna - bialko multipotencjalne

Warianty tytułu

EN
Lactoferrin - a multipotential protein

Języki publikacji

PL

Abstrakty

EN
Lactoferrin is an iron-binding protein from the transferrin family and was first isolated from milk. Lactoferrin is produced by polymorph nuclear leukocytes and epithelial cells of many mammalian species and is present in such mucosal secretions as tears, saliva, seminal and vaginal fluids as well as in several organs and blood. Many biological functions of lactoferrin have been identified: iron absorption, bacteriostatic, bactericidal, fungicidal, antiviral, antiparasitic and antitumour activities. It is also well known for its immunomodulatory and antiinflammatory properties. Additionally, lactoferrin is thought to possess protease, ribonuclease, procoagulant and transcription factor activities. Nowadays bovine lactoferrin is isolated and purified on an industrial scale and used for food preservation and production of infant formulas, yogurt, skim milk, chewing gum, cosmetic formulas, nutritional supplements and therapeutic supplements for pets. The use of lactoferrin as an immunostimulator is a promising area especially in the case of patients with immunosupression.

Słowa kluczowe

Wydawca

-

Rocznik

Tom

63

Numer

02

Opis fizyczny

s.136-139,bibliogr.

Twórcy

  • Uniwersytet Warminsko-Mazurski, ul.Oczapowskiego 13, 10-719 Olsztyn

Bibliografia

  • 1. Abrink M., Larsson E., Gobl A., Hellman L.: Expression of lactoferrin in the kidney: Implications for innate immunity and iron metabolism. Kidney Int. 2000, 57, 4-10.
  • 2. Adamik B., Właszczyk A.: Laktoferyna - rola w obronie ustroju przed infekcją i właściwości immunotropowe. Post. Hig. Med. Dośw. 1996, 50, 33-41.
  • 3. Arnold D., Di Biase A. M., Marchetti M., Pietrantoni A., Valenti P., Seganti L., Superti F.: Antiadenovirus activity of milk proteins: lactoferrin prevents viral infection. Antivir. Res. 2002, 53, 153-158.
  • 4. Baveye S., Elass E., Mazurier J., Legrand D.: Lactoferrin inhibits the binding of lipopolysaccharides to L-selectin and subsequent production of reactive oxygen species by neutrophils. FEBS Lett. 2000, 469, 5-8.
  • 5. Baveye S., Elass E., Mazurier J., Spik G., Legrand D.: Lactoferrin: A multifunctional glycoprotein involved in the modulation of the inflammatory process. Clin. Chem. Lab. Med. 1999, 37, 3, 281-286.
  • 6. Bellamy W., Takase M., Yamauchi K., Wakabayashi H., Kawase K., Tomita M.: Identification of the bactericidal domain of lactoferrin. Biochimica Biophysica Acta 1992, 1121, 130-136.
  • 7. Bhimani R. S., Vendrov Y., Furmanski P.: Influence of lactoferrin feeding and injection against systemic staphylococcal infections in mice. J. Appl. Microbiol. 1999, 86, 135-144.
  • 8. Branen J., Davidson P. M.: Activity of hydrolysed lactoferrin against foodborne pathogenic bacteria in growth media: the effect of EDTA. Lett. Appl. Microbiol. 2000, 30, 233-237.
  • 9. Brock J.: Lactoferrin: a multifunctional immunoregulatory protein? Immunology Today 1995, 16, 9, 417-419.
  • 10. Brock J. H.: The physiology of lactoferrin. Biochem. Cell. Biol. 2002, 80, 1-6.
  • 11. Drobni P., Näslund J., Evander M.: Lactoferrin inhibits human papillomavirus binding and uptake in vitro. Antivir. Res. 2004, 64, 63-68.
  • 12. Farnaud S., Evans R. W.: Lactoferrin - a multifunctional protein with antimicrobial properties. Mol. Immunol. 2003, 40, 395-405.
  • 13. Guttner Y., Windsor H. M., Viiala C. H., Marshall B. J.: Human recombinant lactoferrin is ineffective in the treatment of human Helicobacter pylori infection. Aliment. Pharm. Therap. 2003, 17, 125-129.
  • 14. Hara K., Ikeda M., Saito S., Matsumoto S., Numata K., Kato N., Tanaka K., Sekihara H.: Lactoferrin inhibits hepatitis B virus infection in cultured human hepatocytes. Hepatol. Res. 2002, 24, 228-235.
  • 15. Haversen L. A., Baltzer L., Dolphin G., Hanson L. A., Mattsby-Baltzer I.: Antiinflamatory activities of human lactoferrin in acute dextran sulphate-induced colitis in mice. Scand. J. Immunol. 2003, 57, 2-10.
  • 16. Ikeda M., Nozaki A., Sugiyama K., Tanaka T., Naganuma A., Tanaka K., Sekihara H., Shimotohno K., Saito M., Kato N.: Characterization of antiviral activity of lactoferrin against hepatitis C virus infection in human cultured cells. Virus Res. 2000, 66, 51-63.
  • 17. Iyer S., Lonnerdal B.: Lactoferrin, lactoferrin receptors and iron metabolism. Eur. J. Clin. Nutr. 1993, 47, 232-241.
  • 18. Levay P. F., Viljoen M.: Lactoferrin: a general review. Haematologica 1995, 80, 3, 252-267.
  • 19. Lonnerdal B., Iyer S.: Lactoferrin: molecular structure and biological function. Annual Review of Nutrition 1995, 15, 93-110.
  • 20. Marchetti M., Trybala E., Superti F., Johansson M., Bergström T.: Inhibition of herpes simplex virus infection by lactoferrin is dependent on interference with the virus binding to glycosaminoglycans. Virology 2004, 318, 405-413.
  • 21. Peen E., Johansson A., Engquist M., Skogh T.: Hepatic and extrahepatic clearance of circulating human lactoferrin: an experimental study in rat. Eur. J. Haematol. 1998, 61, 3, 151-159.
  • 22. Shin K., Yamauchi K., Teraguchi S., Hayasawa H., Tomita M., Otsuka Y., Yamazaki S.: Antibacterial activity of bovine lactoferrin and its peptides against enterohaemorrhagic Escherichia coli O157:H7. Lett. Appl. Microbiol. 1998, 26, 407-411.
  • 23. Steijns J. M.: Milk ingredients as nutraceuticals. Society of Dairy Technology 2001, 54, 3, 81-88.
  • 24. Tanaka T., Nakatani S., Xuan X., Kumura H., Igarashi I., Shimazaki K.: Antiviral activity of lactoferrin against canine herpesvirus. Antivir. Res. 2003, 60, 193-199.
  • 25. Teraguchi S., Ozawa K., Yasuda S., Shin K., Fukuwatari Y., Shimamura S.: The bacteriostatic effects of orally administered bovine lactoferrin of intestinal Enterobacteriaceae of SPF mice fed bovine milk. Biosci. Biotech. Bioch. 1994, 58, 482-487.
  • 26. Teraguchi S., Shin K., Ozawa K.: Bacteriostatic effect of orally administered bovine lactoferrin on proliferation of Clostridium species in the gut of mice fed bovine milk. Appl. Environ. Microb. 1995, 61, 501-506.
  • 27. Tomita M., Wakabayashi H., Yamauchi K., Teraguchi S., Hayasawa H.: Bovine lactoferrin and lactoferricin derived from milk: production and applications. Biochem. Cell Biol. 2002, 80, 109-112.
  • 28. van der Strate B. W. A., Beljaars L., Molema G., Harmsen M. C., Meijer D. K. F.: Antiviral activities of lactoferrin. Antivir. Res. 2001, 52, 225-239.
  • 29. van der Strate B. W. A., Harmsen M. C., The T. H., Sprenger H. G., De Vries H., Eikelboom M. C., Kuipers M. E., Meijer D. K. F., Swart P. J.: Plasma Lactoferrin levels are decreased in end-stage AIDS-patients. Viral Immunol. 2000, 12, 3, 197-203.
  • 30. Ward P. P., Uribe-Luna S., Conneely O. M.: Lactoferrin and host defense. Biochem. Cell Biol. 2002, 80, 95-102.
  • 31. Yamauchi K., Toida T., Nishimura S., Nagano E., Kusuoka O., Teraguchi S., Hayasawa H., Shimamura S., Tomita M.: 13-week oral repeated administration toxicity study of bovine lactoferrin in rats. Food Chem. Toxicol. 2000, 38, 503-512.

Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

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