Witaminy a stabilność struktury DNA

• Autorzy: Nowicka G , Wlodarczyk M.

Warianty tytułu

RO

Vitamins and DNA structure stability

• Języki publikacji: PL

Abstrakty

PL

Nieodpowiednio zbilansowana dieta może zaburzać stabilność genomu poprzez wpływ na syntezę i naprawę DNA, indukowanie zmian epigenetycznych i sprzyjanie powstawaniu uszkodzeń w strukturze DNA. W efekcie może prowadzić do zmian w ekspresji genów i rozwoju procesów patologicznych, w tym procesu nowotworowego. Witaminy odgrywające istotną rolę w regulacji procesów metabolicznych wpływają także na strukturę DNA. Udokumentowanie roli poszczególnych witamin, współdziałania między różnymi witaminami oraz między witaminami a innymi składnikami diety w zapewnieniu stabilności struktury DNA, jest niezbędne dla określenia relacji między poziomem spożycia witamin a ryzykiem rozwoju chorób nowotworowych i degeneracyjnych.

Słowa kluczowe

PL

zywienie czlowieka; dieta; bilansowanie; witaminy; przeciwutleniacze; genomy; stabilnosc genomu; naprawa DNA; DNA; metylacja DNA; oksydacja DNA; procesy metaboliczne; metabolizm czlowieka; ochrona zdrowia; profilaktyka; badania genetyczne

• Wydawca: -
• Czasopismo: Żywienie Człowieka i Metabolizm
• Rocznik: 2009
• Tom: 36
• Numer: 5-6
• Opis fizyczny: s.714-722,rys.,bibliogr.

Twórcy

autor

Nowicka G

• Instytut Zywnosci i Zywienia, ul.Powsinska 61/63, 02-903 Warszawa

autor

Wlodarczyk M.

Bibliografia

• 1. Bull C., Fenech M.: Genome-health nutrigenomics and nutrigenetics: nutritional requirements or “nutriomes” for chromosomal stability and telomere maintenance at the individual level. Proceedings of the Nutr. Soc. 2008, 67,146-156.
• 2. Ames B.N.: Micronutrient deficiencies. A major cause of DNA damage. Ann.NY Acad. Sci. 1999, 889, 87-106.
• 3. Fenech M., Ferguson L.R.: Micronutrients and Genomic Stability. Mutation Res. 2001, vol. 475, 1-6.
• 4. Strover P.J.: Physiology of folate and vitamin B12 in health and disease. Nutr. Rev. 2004, 62, 3-12.
• 5. Blount B.C., Mack M.M., Wehr C.M., et al.: Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neural damage. Proc Natl Acad Sci USA 1997, 94, 3290-95.
• 6. Guttmacher A.E., Collins F.S.: Genomic Medicine . A Primer. New Engl. J. Med. 2002, 347, 1512-6.
• 7. Cravo M., Fidalgo P., Pereira A.D.: DNA methylation as an intermediate biomarker in colorectal cancer: modulation by folic acid supplementation. Eur. J. Cancer. Prev 1994, 3, 473-9.
• 8. Titenko-Holland N., Jacob R.A., Shang N. et al.: Micronuclei in lymphocytes and exfoliated buccal cells of postmenopausal women with dietary changes in folate. Mut.Res. 1998, 417, 101-14.
• 9. Cole B.F., Baron J.A., Sandler R.S., et al.: Folic acid for the prevention of colorectal adenomas: a randomized clinical trial. JAMA 2007, 297, 2351-9.
• 10. Hazra A., Selhub J., Chao W-H., et al.: Uracil misincorporation into DNA and folic acid supplementation. Am J Clin Nutr 210, 91, 160-5.
• 11. Kapiszewska M., Kalemba M., Wojciech U., Milewicz T.: Uracil misincorporation into DNA of leukocytes of young women with positive folate balance depends on plasma vitamin B12 concentrations and methylenetetrahydrofolate reductase polymorphisms: a pilot study. J Nutr Biochem 2005, 16: 467-78.
• 12. bastern G.P., Duthie S.J., Pirie L., et al.: Sensitivity of markers of DNA syability and DNA repair activity to folate supplementation in healthy women. Br J Cancer 2006, 94, 1942-7.
• 13. van den Donk m., van Engeland M., Pellis L., et al.: Dietary folate intake in combination with MTHFR C677T genotype and promoter mrthylation of tumor suppressor and DNA repair genes in sporadic colorectal adenomas. Cancer Epidemiol Biomarkers Prev 2007, 16, 327-33.
• 14. Giovannucci E., Stampfer M.J., Colditz G.A. et al.: Multivitamin use, folate and colon cancer in women in the Nearses¿Health Study. Ann. Int. Med., 1998, 129,517-24.
• 15. Giovannucci E., Chen J., Smith-Warner S.A., et al.: Methylenetetrahydrofolate reductase, alcohol dehydrogenase, diet, and the risk of colorectal adenomas. Cancer Epidemiol Biomarkers Prev 2003, 12, 970-9.
• 16. Martinez M.E., Henning S.M., Alberts D.S.: Folate and colorectal neoplasia, relation between plasma and dietary markers of folate and adenoma recurrence. Am J Clin Nutr 2004, 7, 691-7.
• 17. Chanson A., Parnell L.D., Ciappio E.D., et al.: Polymorphisms in uracil processing genes, but not one-carbon nutrients, are associated with altered DNA uracil concentration in an urban Puerto Rican population. Am. J. Clin. Nutr., 2009, 89, 1927-36.
• 18. Zheo R., Russel R.G., Wang Y.: Rescue of embryonic ethality in reduced folate carrier-deficient mice by maternal folic acid supplementation reveals early neonatal failure of hematopoietic organs. J. Biol. Chem., 2001, 276, 10224-8.
• 19. Saitsu H., Ishibashi M., Nakano H., Shiota U.: Spatial and temporal expression of folate-binding protein 1 is closely associated with anterior neural tube closure in mice. Dev. Dyn. 2003, 226,112-7.
• 20. Finnell R.H., Greer U.A., Barber R.C., Piedrahita J.A.: Neural tube and craniofacial defects with special emphasis on folate pathway genes. Crit. Rev. Biol. Med. 1998, 9, 38-53.
• 21. MRC Vitamin Study Research Group. Prevention of neural tube defects, results of the Medical Research Council Vitamin Study. Lancet 1991, 338, 131-36.
• 22. Wang L., Wang F., Guan J., et al.: Relation between hypomethylation of long interspersed nucleotide elements and risk of neural tube defects. Am. J. Clin. Nutr. 2010, 91,1359-67.
• 23. Strover P.J.: One-carbon metabolism genome interactions in folate associated pathologies. J. Nutr. 2009, 139, 2402-5.
• 24. Graf W.D., Oleinik O.E.: The study of neural tube defecys after the Human Genome Project and folic acid fortification of foods. Eur Pediatr Surg 2000, Suppl.1, 9-12.
• 25. Shaw G.M., Finnell R.H., Blom H.J., et al.: Choline and neural tube defects in a folate fortified population. Epidemiology 2009, 20, 714-9.
• 26. Finnell R.H., Blom H.J., Shaw G.M.: Does global hypomethylaton contribute to susceptbility to neural tube defects ? Am. J. Clin. Nutr. 2010, 91, 1153-5.
• 27. Fraga C., Matchnik P.A., Shigenaga M.U. et al.: Ascorbic acid protects against endogenous oxidative DNA damage in human sperm. Proc. Natl. Acad. Sci. USA 1991, 88, 11003-6.
• 28. Ames B.N., Matchnik P.A., Fraga C.G., Shigenaga M.U., Hagen T.M.: Antioxidant prevention of birth defects and cancer. W „Male-Mediated Developmental Toxicity, ed. D.R. Mattison, A. Olshan; Plenum Press, New York, 1994, str. 243-59.
• 29. Konopacka M., Widel M., Rzeszowska-Wolny J.: Modifinging effect of vitamin C, E and betacarotene against gamma-ray induced DNA damage in mouse cells. Mut. Res. 1998, 417, 85-94.
• 30. Claycombe U.J., Meydani S.N. Vitamin E and genome stability. Mut. Rev. 2001, 475,37-44.
• 31. Stainmetz K.A., Potter J.D.: Vegetables, fruits and cancer prevention. J Am Diet Assoc 1996, 96, 1027-39.
• 32. Ladas E., Kelly K.M.: The antioxidant debate. Explore (NY) 201, 6, 75-85.
• 33. Aspects of antioxidant foods and supplements in health and disease. Nutr Rev 2009, 67 (Suppl.1), S140-S144.
• 34. Talvas J, Caris-Veyrat C, Guy L, et al.: Differential effects of lycopene consumed as tomato paste and lycopene in the form of purified extract on target genes of cancer prostatic cells. Am. J. Clin. Nutr. 2010, 91, 1716-24.
• 35. Lu QY, Hyng JC, Heber D, et al.: Inverse association between plasma lycopene and other carotenoids and prostate cancer. cancer Epidemiol Biomarkers Prev 2001, 10,749-56.
• 36. Bjelovic G, Nikolova D, Gluud LL, Simonetti RG, Gluud C.: Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis. JAMA 2007, 297,749-56.
• 37. Gaziano JM, Glynn RJ, Christen WG, et al.: Vitamins E and C in the prevention of prostate cancer and total cancer in men: the Physicians. Health Study II randomized controlled trial. JAMA 2009, 301, 52-62.
• 38. Pryor W.A., Stahl W., Cheryl L.R.: Beta-Carotene: from biochemistry to clinical trials. Nutr. Rev. 2000, 58,39-56.
• 39. Fenech M., Budhurst P., Luderer W., et al.: Low intake of calcium, folate, nicotinic acid, vitamin E, retinol, beta-carotene and high intake of panthotenic acid, biotyn, and riboflavin are significantly associated with increased genome instability - results from a dietary intake and micronucleus index survey in South Australia. Carcinogenesis 2005, 26, 991-9.
• 40. Heinonen O.P., Huttunen J.K., Albanes D. et al.: The effect of vitamin E and beta-carotene on the incidence of lung cancer and other cancers in male smokers. New Engl. J. Med., 1994, 330, 1029-36.
• 41. Larsson SC, Bergkvist L, Wolk A.: Dietary carotenoids and risk of hormone receptor defined breast cancer in a prospective cohort of Swedish women. Eur. J. Cancer 2010, 46,1079-85.
• 42. Larsson SC, Ahesson A, Bergkvist L, Wolk A.: Multivitamins use and breast cancer incidence in a prospective cohort of Swedish women. Am J Clin Nutr 2010, 91, 1268-72.
• 43. Chatterjee M. Vitamin D and genomic stability. Mut. Res. 2001, 475,69-88.
• 44. Anderson L.N., Cotterchio M., Vieth R., Knight J.A.: Vitamin D and calcium intakes and breast cancer risk in pre- and postmenopausal women. Am J Clin Nutr 2010, 91, 1699-707.
• 45. Garland C.F., Gorham E.D., Mohr S.B., Garland F.C.: Vitamin D for cancer prevention: global perspective. Ann Epidemiol 2009, 19, 468-483.. 46. Shapira N.: Nutritional approach to sun protection: a suggested complement to external strategies. Nutr. Rev. 2010, 68, 75-86.