Enamel matrix derivative Emdogain as an adjuvant for a laterally-positioned flap in the treatment of gingival recession: an electron microscopic appraisal

• Autorzy: Lafzi A , Farahani R.M. , Tubbs R.S. , Roushangar L. , Shoja M.M.
• Języki publikacji: EN

Abstrakty

EN

Enamel matrix derivative (EMD), such as Emdogain®, has been suggested for the improvement of wound healing in periodontal surgical therapy. The present qualitative study seeks to illustrate the ultrastructural changes associated with a human gingival wound at 10 days after the application of EMD as an adjunct to a laterally-positioned flap in a patient with gingival recession. An otherwise healthy patient, who had been suffering from bilateral gingival recession defects on teeth #23 and #26, was studied. One defect was treated with a laterally-positioned flap, while the other was treated with a combination of EMD and a laterally-positioned flap. Ten days after the operation gingival biopsy specimens were obtained from the dentogingival region and examined using a transmission electron microscope. A considerable difference was found in both the cellular and extracellular phases of EMD and non-EMD sites. The fibroblasts of EMD site were more rounded with plump cytoplasms and euchromatic nuclei. A well-developed rough endoplasmic reticulum and numerous mitochondria could be detected. In contrast, the fibroblasts of non-EMD site were of flattened spindle-like morphology. While the signs of apoptosis could rarely be detected at EMD site, apoptotic bodies and ultra-structural evidence of apoptosis (crescent-like heterochromatic nuclei and dilated nuclear envelopes) were consistent features at non-EMD site. The extracellular matrix at EMD site mainly consisted of well-organised collagen fibres, while non-EMD site contained sparse and incompletely-formed collagen fibres. Coccoid bacteria were noted within the extracellular matrix and neutrophils at non-EMD site. It seems that EMD may enhance certain features of gingival wound healing, which may be attributable to its anti-apoptotic, anti-bacterial or anti-inflammatory properties.

Słowa kluczowe

EN

patient; gingival recession; therapy; dentistry; Emdogain drug; ultrastructure; gingiva

• Wydawca: -
• Czasopismo: Folia Morphologica
• Rocznik: 2007
• Tom: 66
• Numer: 2
• Opis fizyczny: p.100-103,fig.,ref.

Twórcy

autor

Lafzi A

• School of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran

autor

Farahani R.M.

autor

Tubbs R.S.

autor

Roushangar L.

autor

Shoja M.M.

Bibliografia

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