PL EN


Preferencje help
Widoczny [Schowaj] Abstrakt
Liczba wyników
2008 | 55 | 4 |

Tytuł artykułu

Identification of 2-[2-nitro-4-[trifluoromethyl]benzoyl]-cyclohexane-1,3-dione metabolites in urine of patients suffering from tyrosinemia type I with the use of1H and 19F NMR spectroscopy

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
Organic extracts of six urine samples from children treated with nitisinone, a medicine against tyrosinemia type I, were investigated by 1H and 19F NMR spectroscopy. The presence of unchanged 2-[2-nitro-4-(trifluoromethyl)benzoyl]cyclohexane-1,3-dione (NTBC), 6-hydroxy-2-[2-nitro-4-(trifluoromethyl)benzoyl]cyclohexane-1,3-dione (NTBC-OH) and 2-nitro-4-trifluoromethylbenzoic acid (NTFA) as well as a few other unidentified compounds containing CF3 group was documented.

Wydawca

-

Rocznik

Tom

55

Numer

4

Opis fizyczny

p.749-752,fig.,ref.

Twórcy

  • Warsaw University of Technology, Noakowskiego 3, 00-664 Warsaw, Poland
autor
autor

Bibliografia

  • Brownlee JM, Johnson-Winters K, Harrison DHT, Moran GR (2004) Structure of the ferrous form of (4-hydroxyphenyl)pyruvate dioxygenase from Streptomyces avermitilis in complex with the therapeutic herbicide, NTBC. Biochemistry 43:6370-6377.
  • Cheng M-J, Lee SJ, Chang Y-Y, Wu S-H, Tsai I-L, Jayaprakasam B, Chen I-S (2003) Chemical and cytotoxic constituents from Peperomia sui. Phytochemistry 63:603-608.
  • Holme E, Lindstedt S (1998) Tyrosinaemia type I and NTBC (2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione). J Inherit Metab Dis 21:507-517.
  • Kavana M, Moran GR (2003) Interaction of (4-hydroxyphenyl)pyruvate dioxygenase with the specific inhibitor 2-[2-nitro-4-(trifluoromethyl)benzoyl]-1,3-cyclohexanedione. Biochemistry 42:10238-10245.
  • Linstedt S, Holme E (1992) Treatment of hereditary tyrosinemia type 1 by inhibition of 4-hydroxyphenylpyruvate dioxygenase. Lancet 340:813-817.
  • Lock EA, Ellis MK, Gaskin P, Robinson M, Auton TR, Provan WM, Smith LL, Prisbylla MP, Mutter LC, Lee DL (1998) From toxicological problem to therapeutic use: The discovery of the mode action of 2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione (NTBC), its toxicology and development as a drug. J Inherit Metab Dis 21: 498-506.
  • Mitchell G, Bartlett DW, Fraser TEM, Hawkes TR, Holt DC, Townson JK, Wichert RA (2001) Mesotrione: a new selective herbicide for use in maize. Pest Manag Sci 57:120-128.
  • Montes NA, Burger U (1996) The cyanide catalyzed isomerisation of enol esters derived from cyclic 1,3-diketones. Tetrahedron Lett 37:1007-1010.
  • Neidig ML, Decker A, Kavana M, Moran GR, Solomon EI (2005) Spectroscopic and computational studies of NTBC bound to the non-heme iron enzyme (4-hydroxyphenyl)pyruvate dioxygenase: Active site contributions to drug inhibition. Biochem Biophys Res Commun 338:206-214.
  • Pronicka E, Rowinska E, Zawadzki J, Holme E, Linstedt S (1996) Treatment of two children with hereditary tyrosinaemia type I and long-standing renal disease with a 4-hydroxyphenylpyruvate dioxygenase inhibitor (NTBC). J Inherit Metab Dis 19:234-238.
  • Russo PA, Mitchell GA, Tanguay RM (2001) Tyrosinemia: A review. Pediatr Dev Pathol 4:212-221.
  • Secor J (1994) Inhibition of barnyardgrass 4-hydroxyphenylpyruvate dioxygenase by sulcotrione. Plant Physiol 106:1429-1433.
  • Szczecinski P, Gryff-Keller A, Molchanov S (2007) 1H NMR, 13C NMR, and computational DFT studies of the structure of 2-acylcyclohexane-1,3-diones and their alkali metal salts In solution. J Org Chem 71:4636-4641.
  • Zaitsev VG, Polozov GI, Lakhvich FA (1994) Synthesis of 2-acyl-4-hydroxycyclohexane-1,3-diones, Kairomones and defensive compounds of some insects. Tetrahedron 50:6377-6386.
  • Zaitsev VG, Sachava DG, Yankovskaya GS, Garbuz NI (2000) Synthesis of the rac-6-hydroxy-3-methoxycyclohex-2-enone and resolution through recrystallization of its diastereomeric N-tosyl-(S)-proline esters. Chirality 12:287-290.

Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

bwmeta1.element.agro-article-7c0783aa-da41-4f9d-8e5c-831751e43fd5
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.