The influence of different doses of lithium administrated in drinking water on lipid peroxidation and the activity of antioxidant enzymes of rats

• Autorzy: Kielczykowska M , Pasternak K. , Musik I. , Wronska-Tyra J. , Hordyjewska A.
• Języki publikacji: EN

Abstrakty

EN

Lithium compounds are widely employed in medicine. However, both its positive and negative effects have been revealed. We have tried to evaluate the influence of oral administration of different Li2C03 doses for a period of 8 weeks on the elements of antioxidant status in male rats. The activity of two main antioxidant enzymes: glutathione peroxidase (GPx) and superoxide dismutase (SOD) as well as the con­centration of malonyldialdehyde (MDA) - the marker of lipid peroxidation - have been studied. In blood no significant changes of both lipid peroxidation levels and enzyme activity have been found. In tissues enzymes' activities have decreased, significantly in liver (SOD) and kidney (GPx and SOD). No evidence of lithium-induced lipid peroxidation in the tissues has been observed. In the case of brain the Li protective effect against lipid peroxidation has been displayed. In conclusion, the antioxidant status has not been af­fected in blood and suppressed in tissues as a consequence of Li exposure. The tissue of brain has seemed to be the least attacked organ.

• Wydawca: -
• Czasopismo: Polish Journal of Environmental Studies
• Rocznik: 2006
• Tom: 15
• Numer: 5
• Opis fizyczny: p.747-751,ref.

Twórcy

autor

Kielczykowska M

• Feliks Skubiszewski Medical University of Lublin, Staszica 4, 20-081 Lublin, Poland

autor

Pasternak K.

autor

Musik I.

autor

Wronska-Tyra J.

autor

Hordyjewska A.

Bibliografia

• 1. SUBHASH M. N., VINOD K.Y., SRINIVAS B.N. Differ­ential effect of lithium on 5-HT1 receptor-linked system in regions of rat brain. Neurochem. Int. 35, 337, 1999.
• 2. KOONG S.S., REYNOLDS J.C., MOVIUS E.G., KEEN- AN A.M., AIN K.B., LAKSHMANAN M.C., ROBBINS J. Lithium as a potential adjuvant to 131I therapy of metastatic, well differentiated thyroid carcinoma. J. Clin. Endocrinol. Metab. 84, 912, 1999.
• 3. BOGAZZI F., BARTALENA L., BROGIONI S., SCAR- CELLO G., BURELLI A., CAMPOMORI A., MANETTI L., ROSSI G., PINCHERA A., MARTINO E. Comparison of radioiodine with radioiodine plus lithium in the treatment of Graves' hyperthyroidism. J. Clin. Endocrinol. Metab. 84, 499, 1999.
• 4. BOGAZZI F., BARTALENA L., CAMPOMORI A., BRO­GIONI S., TRAINO C., DE MARTINO F., ROSSI G., LIP- PI F., PINCHERA A., MARTINO E. Treatment with lithium prevents serum thyroid hormone increase after thionamide withdrawal and radioiodine therapy in patients with Graves' disease. J. Clin. Endocrinol. Metab. 87, 4490, 2002.
• 5. ALVAREZ G., MUNOZ-MONTANO J.R., SATRUSTEGUI J., AVILA J., BOGONEZ E., DIAZ-NIDO J. Lithium pro­tects cultured neurons against P-amyloid-induced neurode­generation. FEBS Lett. 453, 260, 1999.
• 6. CHUANG D.M. Neuroprotective and neurotrophic actions of mood stabilizer lithium: can it be used to treat neurode­generative diseases? Crit. Rev. Neurobiol. 16, 83, 2004.
• 7. MANJI H.K., MOORE G.J., CHEN G. Lithium at 50: have the neuroprotective effects of this unique cation been over­looked? Biol. Psychiatry. 46, 929, 1999.
• 8. SPARSA A., BONNETBLANC J.M. [Lithium] Ann. Der­matol. Venereol. 131, 255, 2004. (In French)
• 9. RODRIGUEZ-GIL J.E., GUINOVART J.J., BOSCH F. Lith­ium restores glycogen synthesis from glucose in hepatocytes from diabetic rats. Arch. Biochem. Biophys. 301, 411, 1993.
• 10. HU M., WU Y.S., WU H.W. Effects of lithium deficiency in some insulin-sensitive tissues of diabetic Chinese hamsters. Biol. Trace Elem. Res. 58, 91, 1997.
• 11. BERĘSEWICZ M. [Lithium carbonate as an agent aug­menting the antidepressants in drug-resistant depresssions] Farmakoter. Psychiat. Neurol. 1, 40, 2000. (In Polish)
• 12. CARNEY S.M., GOODWIN G.M. Lithium - a continuing story in the treatment of bipolar disorder. Acta Psychiatr. Scand. Suppl. 426, 7, 2005.
• 13. DICHTL B., STEVENS A., TOLLERVEY D. Lithium toxicity in yeast is due to the inhibition of RNA processing en­zymes. EMBO J. 16, 7184, 1997.
• 14. CHAKRABARTI S., CHAND P.K. Lithium-induced tardive dystonia treated with clozapine. Neurol. India 50, 473, 2002.
• 15. THAKUR S.C., THAKUR S.S., CHAUBE S.K. SINGH S.P. Subchronic supplementation of lithium carbonate induces reproductive system toxicity in male rat. Reprod. Toxicol. 17, 683, 2003.
• 16. YENUSH L., BELLÉS J.M., LóPEZ-CORONADO J.M., GIL-MASCARELL R., SERRANO R., RODRÍGUEZ P.L. A novel target to lithium therapy. FEBS Lett. 467, 321, 2000.
• 17. YO M.S., ROMMES J.H., SPRONK P.E., JANSSEN J.C. [Lithium, a potentially dangerous drug]. Ned. Tijdschr. Ge- neeskd. 149, 273, 2005. (In Dutch)
• 18. KOZMA C. Neonatal toxicity and transient neurodevelop- mental deficits following prenatal exposure to lithium: An­other clinical report and a review of the literature. Am. J. Med. Genet. 132, 441, 2005.
• 19. DREWA G., KRZYŻYŃSKA-MALINOWSKA E., WOŹNIAK A., PROTAS-DROZD F., MILA-KIERZEN- KOWSKA C., ROZWODOWSKA M., KOWALISZYN B., CZAJKOWSKI R. Activity of superoxide dismutase and catalase and the level of lipid peroxidation products reac­tive with TBA in patients with psoriasis. Med. Sci. Monit. 8, BR338, 2002.
• 20. SONG C., KILLEEN A.A., LEONARD B.E. Catalase, su­peroxide dismutase and glutathione peroxidase activity in neutrophils of sham-operated and olfactory-bulbectomised rats following chronic treatment with desipramine and lithi­um chloride. Neuropsychobiology. 30, 24, 1994.
• 21. MATÉS J.S., PÉRES-GóMEZ C., BLANCA M. Clinical and biological activity of free radical 'scavengers' in allergic diseases. Clin. Chim. Acta 296, 1, 2000.
• 22. YNAL M.E., KANBAK G., SUNAL E. Antioxidant enzyme activities and malondialdehyde levels related to aging. Clin. Chim. Acta 305, 75, 2001.
• 23. CIRAK B., INCI S., PALAOGLU S., BERTAN V. Lipid peroxidation in cerebral tumors. Clin. Chim. Acta 327, 103, 2003.
• 24. SONTAKKE A.N., TARE R.S. A duality in the roles of reac­tive oxygen species with respect to bone metabolism. Clin. Chim. Acta 318, 145, 2002.
• 25. HU H.L., FORSEY R.J., BLADES T.J, BARRATT M.E.J., PARMAR P., POWELL J.R. Antioxidants may contribute in the fight against ageing: an in vitro model. Mech. Age. Dev. 121, 217, 2000.
• 26. PAGLIA D.E., VALENTINE W.N. Studies on the quantita­tive and qualitive charakterization of erythrocyte glutathione peroxidase. J. Lab. Clin. Med. 70, 158, 1967.
• 27. ARTHUR J.R., BOYNE R. Superoxide dismutase and glutathione peroxidase activities in neutrophils from selenium deficient and copper deficient cattle. Life Sci. 36, 1569, 1985.
• 28. BRADFORD M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248, 1976.
• 29. LEDWOŻYW A., MICHALAK J., STĘPIEŃ A., KĄDZIOŁKA A. The relationships between plasma triglyc­erides, cholesterol, total lipids and lipid peroxidation prod­ucts during human atherosclerosis. Clin. Chim. Acta 155, 275, 1986.
• 30. ABDALLA D.S.P., BECHARA E.J.H. The effect of chlorpromazine and Li2CO3 on the superoxide dismutase and glutathione peroxidase activities of rat brain, liver and eryth­rocytes. Biochem. Mol. Biol. Int. 34, 1085, 1994.
• 31. HU M. WU Y., WU H. Influence of streptozotocin-induced diabetes in rats on the lithium content of tissue and the effect of dietary lithium supplements on this diabetic condition. Metabolism 48, 558, 1999.
• 32. ABDALLA D.S.P., MONTEIRO H.P., OLIVEIRA J.A.C., BECHARA E.T.J. Activities of superoxide dismutase and glutathione peroxidase in schizophrenic and manic-depres­sive patients. Clin. Chem. 32, 805, 1986.
• 33. SHUKLA G.S. Mechanism of lithium action: in vivo and in vitro effects of alkali metals on brain superoxide dismutase. Pharmacol. Biochem. Behav. 26, 235, 1987.
• 34. GLÖCKNER R. Lipid peroxidation in brain tissue of new­born rats derived from two models of disturbed pregnancy. Exp. Toxic. Pathol. 45, 99, 1993.
• 35. TANDON A., DHAWAN D.K., NAGPAUL J.P. Effect of lithium on hepatic lipid peroxidation and antioxidative en­zymes under different dietary protein regiments. J. Appl. Toxicol. 18, 187, 1998.
• 36. LI S., LONG S. [Effects of manganese, zircon and lithium alone on rat liver lipid peroxidation]. Wei Sheng Yan Jiu 30, 142, 2001. (In Chinese)
• 37. SRIVASTAVA P., SAXENA A.K., KALE R.K., BAQUER N.z. Insulin like effects of lithium and vanadate on the altered antioxidant status of diabetic rats. Res. Commun. Chem. Pathol. Pharmacol. 80, 283, 1993.
• 38. SUWALSKA A., ŁOJKO D., RYBAKOWSKI J. [The in­fluence of mood-normalizing drugs on the cognitive func­tions]. Psychiat. Pol. 35, 245, 2001 (In Polish)