Biological evaluation of analogues of an insect neuropeptide proctolin

• Autorzy: Woznica I. , Szeszel-Fedorowicz W. , Rosinski G. , Konopinska D.
• Języki publikacji: EN

Abstrakty

EN

Continuing our studies on proctolin (Arg-Tyr-Leu-Pro-Thr) we performed the syn­thesis and biological evaluation of 52 analogues substituted in position 2, 3, 4, and 5 of the peptide chain. The peptides were bioassayed for cardiotropic activity in vitro on Tenebrio molitor and myotropic activity on foregut of Schistocerca gregaria. Twenty analogues retained 20-80% of proctolin activity.

Słowa kluczowe

EN

peptide chain; neuropeptide proctolin; proctolin analogue; proctolin; peptide; Schistocerca gregaria; Tenebrio molitor; insect

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2004
• Tom: 51
• Numer: 1
• Opis fizyczny: p.115-119,ref.

Twórcy

autor

Woznica I.

• University of Wroclaw, 50-583 Wroclaw, Poland

autor

Szeszel-Fedorowicz W.

autor

Rosinski G.

autor

Konopinska D.

Bibliografia

• Gray AS, Osborne RH, Jewess PJ. (1994) Pharmacology of proctolin receptors in the isolated foregut of the locust Schistocerca gregaria - identification of [N-methyl-L-tyrosine2]-proctolin as a potent receptor antagonist. J Insect Physiol.; 40: 595-600.
• Konopinska D, Rosinski G. (1999) Proctolin an insect neuropeptide. JPeptSci.; 5: 533-46.
• Kuczer M, Rosinski G, Lisowski M, Picur B, Konopinska D. (1996) New proctolin analogues modified by D-amino acids in the peptide chain and their high cardioexcitatory effect on Tenebrio molitor. Int J Pept Protein Res.; 48: 286-91.
• Rosinski G, Gade G. (1988) Hyperglycaemic and myoactive factors in the corpora cardiaca of the mealworm Tenebrio molitor. J Insect Physiol.; 33: 451-63.