The effect of blood-cycle synchronicity on the chloroquine sensitivity of Plasmodium chabaudi

• Autorzy: Tahar R , Gautret P. , Landau I.
• Języki publikacji: EN

Abstrakty

EN

Plasmodium chabaudi, a rodent malaria parasite with a synchronous asexual cycle in the blood, depending on the host’s circadian rhythm, was desynchronized by modifying its normal timing: blood taken from a donor mouse in the morning was kept 8 h at +4°C and inoculated in the evening into naive mice. When the infection had become asynchronous (from day 4 to day 7) mice were treated with a single dose of chloroquine. The efficacy of chloroquine was lower in mice with an asynchronous infection than in the control mice with a normally synchronous infection.

Słowa kluczowe

EN

malaria; parasite; chloroquine; synchronicity index; blood; Plasmodium chabaudi

• Wydawca: -
• Czasopismo: Acta Parasitologica
• Rocznik: 1995
• Tom: 40
• Numer: 2
• Opis fizyczny: p.69-71,fig.

Twórcy

autor

Tahar R

• Museum National d'Histoire Naturelle, 61 rue Buffon, 75231 Paris cedex 05, France

autor

Gautret P.

autor

Landau I.

Bibliografia

• Beauté-Lafitte A., Altemayer-Caillard V., Chabaud A. G., Landau I. 1994a. Plasmodium yoelii nigeriensis: biological mechanism of resistance to chloroquine. Parasite, 1, 227-233.
• Beauté-Lafitte A., Altemayer-Caillard V., Gonnet-Gonzalez F., Ramiaramanana L., Chabaud A. G., Landau I. 1994b. The chemosensitivity of the rodent malarias. Relationships with the biology of merozoites. International Journal for Parasitology, 24, 981-986.
• Cambie G., Landau I., Chabaud A. G. 1990. Niches horaires des trois especes de Plasmodies coexistant chez un Rongeur de Centrafrique. Compte Rendu Hebdomadaire des Séances de l’Académie des Sciences de Paris, Sér. III, 310, 183-188.
• Cambie G., Caillard V., Beauté-Lafitte A., Ginsburg H., Chabaud A. G., Landau I. 1991. Chronotherapy of malaria: identification of drug-sensitive stage of parasite and timing of drug delivery for improved therapy. Annales de Parasitologie Humaine et Comparée, 66, 14-21.
• Deharo E., Gautret P., Ginsburg H., Chabaud A. G., Landau I. 1994. Synchronization of Plasmodium yoelii nigeriensis and P. y. killicki infection in the mouse by means of Percoll-glucose gradient stage fractionation: determination of the duration of the schizogonic cycle. Parasitology Research, 80, 159-164.
• Gautret P., Deharo E., Tahar R., Chabaud A. G., Landau 1.1995. The adjustment of the schizogonic cycle of Plasmodium chabaudi chabaudi in the blood to the circadian rhythm of the host. Parasite, 2, 69-74.
• Landau I., Lepers J. P., Ringwald P., Rabarison P., Ginsburg H., Chabaud A. G. 1992. Chronotherapy of malaria: improved efficacity of timed chloroquine treatment of patients with Plasmodium falciparum infection. Transactions of the Royal Society of Tropical Medicine and Hygiene, 86, 374-375.