Antithrombotic effect of tissue and plasma type angiotensin converting enzyme inhibitors in experimental thrombosis in rats

• Autorzy: Wojewodzka-Zelazniakowicz M. , Chabielska E. , Mogielnicki A. , Kramkowski K. , Karp A. , Opadczuk A. , Domaniewski T. , Malinowska-Zaprzalka M. , Buczko W.
• Języki publikacji: EN

Abstrakty

EN

This study compared the antihrombotic effect of plasma angiotensin converting enzyme inhibitors (ACE-Is): captopril (CAP), enalapril (ENA) and Tissue ACE-Is: perindopril (PER), quinapril (QUIN) in experimental venous and arterial thrombosis. Normotensive Wistar rats were treated p.o. with CAP (75 mg/kg), ENA (20 mg/kg), PER (2 mg/kg) and QUIN (3 mg/kg) for 10 days. The influence of ACE-Is on coagulation and fibrinolytic systems as well as platelet function was evaluated. The hypotensive effect of ACE-Is was equal in all groups. QUIN mantained the final carotid blood flow at the highest value in comparison to PER and plasma ACE-Is. The arterial thrombus weight was reduced in PER and QUIN groups while venous thrombus weight was also reduced after CAP. Tissue andplasma ACE-Is caused the inhibition of platelet adhesion and aggregation. A reduction of fibrin generation, prolongation of prothrombin time (PT), activated partial thromboplastin time (APTT) and shortening of euglobulin clot lysis time (ECLT) were observed after PER and QUIN treatment. In conclusion, given in equipotent hypotensive doses, Tissue ACE-Is exerted more pronounced antithrombotic effect than plasma ACE-Is in experimental thrombosis. The differences between Tissue and plasma ACE-Is in terms of their more pronounced inhibition of experimental thrombosis may be related to the intensified activation of fibrinolysis and inhibition of coagulation.

Słowa kluczowe

EN

perindopril; antithrombotic effect; angiotensin converting enzyme inhibitor; hemostasis; plasma; enalapril; captopril; quinapril; rat; thrombosis; tissue

• Wydawca: -
• Czasopismo: Journal of Physiology and Pharmacology
• Rocznik: 2006
• Tom: 57
• Numer: 2
• Opis fizyczny: p.231-245,fig.,ref.

Twórcy

autor

Wojewodzka-Zelazniakowicz M.

• Medical University of Bialystok, Mickiewicza 2C Str., 15-089 Bialystok, Poland

autor

Chabielska E.

autor

Mogielnicki A.

autor

Kramkowski K.

autor

Karp A.

autor

Opadczuk A.

autor

Domaniewski T.

autor

Malinowska-Zaprzalka M.

autor

Buczko W.