EN
Insect-parasitic rhabditoid nematodes, S. feltiae and H. bacteriophora, when parasitizing the greater wax moth larvae, produce toxic substances which constitute a specific type of proteolytic activity. These show some similarity to the immune inhibitors released by certain bacterial pathogens of insects. The proteinases of both nematodes selectively destroy the antibacterial activity of immune haemolymph in vitro as well as in vivo. The inhibitory effect on the bactericidal activity is caused by the proteolytic degradation of the immune proteins of the cecropin-like type. Although a decrease in lysozyme activity in nematode-parasitized insects has been observed, the immune inhibitors released by entomogenous rhabditoid nematodes inhibited neither lysozyme synthesis nor its bactericidal acitivity against gram-positive bacteria.