Relation of adrenergic receptors, which have roles in gastroprotective and anti-inflammatory effect of adrenal gland hormones, with cyclooxygenase enzyme levels in rats

• Autorzy: Suleyman H. , Dursun H. , Bilici M. , Cadirci E. , Halici Z. , Gulaboglu M. , Albayrak F.
• Języki publikacji: EN

Abstrakty

EN

Background and Aims: COX-2 enzyme inhibition is responsible for the anti-inflammatory effects of NSAIDs, COX-1 for their effects upon the gastrointestinal system (GIS), along with other side effects. We investigated the relationship between COX levels and those adrenergic receptors known to play a role in gastroprotection and anti-inflammatory activity. Method: The effects of adrenaline and prednisolone on gastric COX-1 and COX-2 levels in both intact and adrenalectomized rats treated with doxazosin, yohimbine, propranolol, and metoprolol were determined. Results: We found that adrenaline increases COX-1 levels in the gastric tissue of both intact and adrenalectomized rats by stimulating -2 receptors. Adrenaline decreases COX-2 levels by stimulating ß-2 adrenergic receptors. Prednisolone inhibits both COX-1 and COX-2 in the gastric tissue of intact rats. In adrenalectomized rats, prednisolone increases gastric COX-1 by stimulating -2 receptors, and decreases COX-2 levels by stimulating ß-2 receptors. Conclusion: Prednisolone cannot bind to a adrenergic receptors in the presence of adrenaline (intact rats) but, in its absence (adrenalectomy), binds to -2 receptors, and stimulates them more effectively than adrenaline, suggesting a direct relationship between -2 adrenergic receptors and COX-1 levels, whereas ß-2 receptors are directly related to COX-2 levels.

Słowa kluczowe

EN

adrenergic receptor; gastroprotective effect; antiinflammatory effect; adrenal gland; hormone; cyclooxygenase; adrenaline; prednisolone; rat

• Wydawca: -
• Czasopismo: Journal of Physiology and Pharmacology
• Rocznik: 2009
• Tom: 60
• Numer: 4
• Opis fizyczny: p.129-134,fig.,ref.

Twórcy

autor

Suleyman H.

• Ataturk University, Erzurum, Turkey

autor

Dursun H.

autor

Bilici M.

autor

Cadirci E.

autor

Halici Z.

autor

Gulaboglu M.

autor

Albayrak F.