Stem cells as a two edged sword - from regeneration to tumor formation

• Autorzy: Kucia M. , Ratajczak M.Z.
• Języki publikacji: EN

Abstrakty

EN

Evidence has accumulated that quiescent stem cells or cells developmentally closely related to them distributed in various organs may be a cellular origin of cancer development. In support of this notion, stem cells (SC) are long-lived cells with distinctive properties of self-renewal and has the potential to proliferate extensively. Given these features, it’s possible that they may become the subject of consecutive accumulated mutations that are crucial for initiation of cancer. Therefore, mutations that occur in normal stem cells might lead to their malignant transformation and tumor initiation. Furthermore, many biological features of normal and cancer SC such as the physiological trafficking of normal and metastasis of cancer stem cells involve similar molecular mechanisms, and we discuss these similarities here.

Słowa kluczowe

EN

stem cell; regeneration; various organ; cancer development; malignant transformation; tumour initiation; cancer stem cell; stem cell trafficking; metastasis

• Wydawca: -
• Czasopismo: Journal of Physiology and Pharmacology. Supplement
• Rocznik: 2006
• Tom: 57
• Numer: 7
• Opis fizyczny: p.5-16,fig.,ref.

Twórcy

autor

Kucia M.

• University of Louisville, Louisville, KY 40202, USA

autor

Ratajczak M.Z.