The effect of Ascaris trypsin inhibitor on proteolytic activity of lungs and kidneys of guinea pig with larval ascariosis and after ascarid homogenate administration

• Autorzy: Wojcik A , Kadlubowski R.
• Języki publikacji: EN

Abstrakty

EN

Trypsin inhibitor, isolated from Ascaris suum tegument reduces in vitro proteolytic activity (pH 7) of lungs and kidneys post-nuclear fractions of guinea pigs with larval ascariosis, pigs after subcutaneous ascarid homogenate administration as well as the activity in control groups. The comparative analysis of effect curves of trypsin inhibitor on the organ proteases revealed stronger reduction of the activity of post-nuclear lung proteases in ascariosis and of kidneys proteases after the injection of Ascaris homogenate than the inhibition of the fractions activity from respective control groups.

Słowa kluczowe

EN

trypsin inhibitor; Ascaris; ascarid homogenate; ascariasis; Ascaris suum; guinea pig; kidney; larva; lung; proteolytic activity

• Wydawca: -
• Czasopismo: Wiadomości Parazytologiczne
• Rocznik: 2001
• Tom: 47
• Numer: 4
• Opis fizyczny: p.711-716,fig.,ref.

Twórcy

autor

Wojcik A

• Medical University of Lodz, Kosciuszki 85, 90-436 Lodz, Poland

autor

Kadlubowski R.

Bibliografia

• KADŁUBOWSKI R., WÓJCIK A. 1990. Proteases and their inhibitors in the host-parasite system. IX. The effect of Ascaris trypsin inhibitor on urine proteolytic activity following treatment with Ascaris tegument homogenate and in experimental larval ascariosis. Acta Parasitol. Pol. 35: 325-332.
• KADŁUBOWSKI R., WÓJCIK A. 1992. Proteases and their inhibitors in the host-parasite system. XI. The activity of proteases of some mammalian organs after Ascaris tegument homogenate administration and in experimental larval ascariasis. Acta Parasitol. Pol. 37: 209-212.
• KHOURY P.B., SOULSBY E.J.L. 1977. Ascaris suum: Immune response during primary infections. Exp. Parasitol. 4 : 141-159.
• KITOH K., WATOH K., CHAYA K., KITAGAWA H., SASAKI Y. 1994.Clinical, hematological and biochemical findings in dogs after introduction of shock by injection of heartworm exteact. Am. J. Vet. Res. 55: 1535-1541.
• OCHĘCKA A., KADŁUBOWSKI R. 1986. Proteases and their inhibitors in the host-parasite system. III. Effect of the parasite (Ascaris) inhibitors on the proteolytic activity of human leucocytes. Acta Parasitol. Pol. 30: 303-312.
• SAPAČ V.K., BARBACHČ'JAN E.A., GUL'JANC E.S., NAUMOV N.N. 1977. [Neuro-humoral and renal mechanisms of formation of the general Schwarzman phenomen in ascaridosis]. Medicinskaya Parazyitologiya 46:166-170 [in Russian].