Effect of gamma-aminobutyric acid and muscimol on corticosterone secretion in rats

• Autorzy: Borycz J , Borycz J.A. , Bugajski J.
• Języki publikacji: EN

Abstrakty

EN

The effect of γ-aminobutyric acid-receptor agonists, GABA and muscimol on the pituitary-adrenocortical activity, measured indirectly through corticosterone secretion, and the receptors involved were investigated in conscious rats. GABA given ip induced a dual effect, in lower dose (10mg/kg) it significantly decreased the resting serum corticosterone levels while in higher doses (100-500mg/kg) it considerably raised that level. Muscimol (0.5mg/kg ip) also increased the corticosterone concentration. Both GABA and muscimol given intracerebroventricularly (icv) induced a significant, dose-related increase in serum corticosterone levels. Bicuculline, a GABAA-receptor antagonist, totally abolished the corticosterone response to GABA but did not influence the response to muscimol. Pretreatment with atropine did not affect the corticosterone response to GABA but significantly diminished the response to muscimol. These results suggest that GABA moderately inhibits the pituitary-adrenal axis at the pituitary level but significantly stimulates it at the hypothalamic level. The stimulatory effect of GABA, but not muscimol, is mediated by hypothalamic GABA A-receptors, and in the effect of muscimol hypothalamic cholinergic, muscarinic receptors are involved to a significant extent.

Słowa kluczowe

EN

corticosterone secretion; pituitary-adrenocortical activity; pituitary hormone; muscarinic receptor; rat; gamma-aminobutyric acid

• Wydawca: -
• Czasopismo: Journal of Physiology and Pharmacology
• Rocznik: 1992
• Tom: 43
• Numer: 3
• Opis fizyczny: p.259-269,fig.

Twórcy

autor

Borycz J

• Polish Academy of Sciences, 31-343 Krakow, Smetna 12, Poland

autor

Borycz J.A.

autor

Bugajski J.

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