Regulacja reakcji obronnej i alergicznej w inwazjach pasozytow

• Autorzy: Doligalska M
• Języki publikacji: PL

Abstrakty

EN

Cytokines regulate development, differentiation and expression of effector function of the immune system. The profile of immune reactions depends on cytokine contents at the recognition of parasite. However, parasites themselves can modify immunological events and favourite these, which allow them to survive. The host immune defence can be transformed into the chronic reaction. Inflammatory reactions result from the recruitment of different cells, to the site where worms are localised. The eosinophil and mast cell migration preferentially is induced. These cells play also a major role in immediate allergic responses. Mast cells can bind allergenspecific IgE to their RcεRI, the high affinity receptor for IgE. Eosinophils, through their receptors for IgGl, IgG2, IgA and IgE are mainly involved in the cytotoxic reaction directed against parasites. Crosslinking of these receptors by antigen binding will lead to subsequent release of stored mediators and cytokines. Granular materials released from mast cell accelerate inflammatory reaction and in the case of intestinal worm parasites may be involved in the expulsion phenomenon. However these cells may also induce Th2 related immunological response because they produce and release of IL-4. Eosinophils are required into the tissue and release cytotoxic and stress proteins including reactive oxygen species. Parasites are destroyed but accelerated reaction results in the destruction of host proteins and cells. Antibodies, cytokines, chemokines and adhesion molecules are essential for elevation of defence against parasites. The role of cytokines, emphasizing IL-5, and function of eosinophils, mast cells and IgE are discussed in terms of induction and effector mechanisms during parasite infections.

Słowa kluczowe

PL

mastocyty; odpowiedz immunologiczna; eozynofile; parazytologia; reakcje obronne; interleukiny; pasozyty; inwazja pasozytnicza; reakcje alergiczne

• Wydawca: -
• Czasopismo: Wiadomości Parazytologiczne
• Rocznik: 2000
• Tom: 46
• Numer: 1
• Opis fizyczny: s.3-20,bibliogr.

Twórcy

autor

Doligalska M

• Uniwersytet Warszawski, Krakowskie Predmiescie 26/28, 00-927 Warszawa

Bibliografia

• ADACHI T., ALAM R. 1998. The mechanism of IL-5 signal transduction. Am. J. Physiol. 275 (Cell Physiol. 44): C623-C633.
• ALAM R., FORSYTHE P., STAFFORD S., FUKUDA Y, 1994. Transforming growth factor beta abrogates the effects of hematopoietins on eosinophils and induces their apoptosis ./. J. Exp. Med. 179: 1041-1045.
• ALBRICH J. M., MCCARTHY C. A., HURST J. K. 1981. Biological reactivity ot hypochlorous acid: amplifications for microbial mechanisms of leukocyte myeloperoxidase. Proc. Natl. Acad. Sci. USA 78: 210-214.
• ASHMAN K., MATHER J.,. WILTSHIRE C., JACOBS H. J., MEEUSEN E. 1995. Isolation of larval surface glycoprotein from Haemonchus contortus and its possible role in evading host immunity. Mol. Biochem. Parasitol. 70: 175-179.
• BAGGIOLINI M., DAHINDEN CA. 1994. CC chemokines in allergic inflammation. Immunol. Today 15: 127-133.
• BEHNKE J. M., BARNARD C. V., WAKELIN D. 1992. Understanding chronic nematode infections: evolutionary considerations, current hypotheses and the way forward. J. Parasitol. 22: 861-907.
• BIDRI M., VOULDOUKIS I., MOSSALAYI M. D, DEBRE P., GUILLOSSON J-J., MAZIER D., AROCK M.1997. Evidence for direct interaction between mast cells and Leishmania parasites. Parasite Immunol. 19: 475-483.
• BOESIGER J., TSAI M., MAURER M., YAMAGUCHI M., BROWN L. F., CLAFFEY K. P. DYORAK H. F., GALLI S. J. 1998. Mast cells can secrete vascular permeability factor/vascular endothelial cell growth factor and exhibit enhanced release after immunoglobulin E-dependent upregulation of Rcε receptor I expression. J. Exp. Med. 188: 1135-1145.
• BOHJANEN P. R., OKAJIMA M., HODES R. J. 1990. Differential regulation of interleukin 4 and interleukin 5 gene expression: a comparison of T-cell gene induction by anti-CD3 antibody orby exogenous lymphokines. Proc. Natl. Acad. Sci. USA 87: 5283-5287.
• BUTIERWORTH A, E., RENOLD H. G., HOUBA V., DAVID J. R., FRANKS D., DAVID P. H., STURROCK R. F. 1977. Antibody-dependent eosinophil-mediated damage to 51 Cr-labelled schistosomula of Schistosoma mansoni: mediation by IgG, and inhibition by antigen-antibody complexes. J. Immunol. 118: 2230-2235.
• - THORNE K. J. I. 1993. Eosinophils and parasitic diseases. In Immunopharmacology of eosinophils. Academic Press LTD, San Diego p. 119.
• CAPRON A., DESSAINT J-P., CAPRON M., JOSEPH M., AMEISEN J. C., TONNEL A. B. 1986. From parasites to allergy: the second receptor for IgE (RcεR;). Immunol. Today 1: 15-17.
• CAPRON M., CAPRON A. 1994. Immunoglobulin E and effector cells in schistosomiasis. Science 264: 1876-1878.
• - TRUONG M-J., ALDERBERT D., GRUART V., SUEMURA M., DELESPESSE G, TOURYIELLE B., CAPRON A. 1991. Heterogeneous expression of CD23 epitopes by eosinophils from patients. Relationships with IgE-mediated functions. Eur. J. Jmmunol. 21: 2423-2425.
• CHAN M. S., MEDLEY G. F., JAIMSON D., BUNDY D. A. P. 1994. The evolution of potential global morbidity attributable to intestinal nematode infections. Parasitology 109: 373-387.
• CHANDRASHEKER R., RAO U. R, SUBRAHMANYAM D. 1990. Antibody-mediated cytotoxic effects m vitro and in vivo of rat cells in infective larvae of Brugia malayi. Int. J. Parasitol. 20: 725-730.
• CHHABARA S., GAUR S. 1988. Airway hyperreactivity in tropical pulmonary eosinophilia. Chest. 93: 1105-1106.
• COFFMAN R. L, SEYMOUR B. W. P., HUDAK S., JACKSON J., RENNICK D. 1989. Antibody to interleukin -5 inhibits helminth-induced eosinophilia in mice. Science 245: 308-310.
• DEAN R. T., FU S., STOCKER R., DAYIES M. J. 1997. Biochemistry and pathology of radicalmediated protein oxidation. Biochem. J. 324: 1-18.
• DE ANDRES B., RAKASZ E., HAGEN M., MCCORMIK M. L., MUELLER A. L., ELLIOT D., METWALI A., SANDOR M., BRJTIGAN B. E., WEINSTOCK J. V., LYNCH R. G. 1997. Lack of Fc-ε receptors on murine eosinophils: implications for the functional significance ofelevated IgE and eosinophils in parasitic infections. Blood 89: 3826-3836.
• DELESPESSE G., SARFATI M., WU C.Y., FOURNIER S., LETELLIER M, 1992. The low affinity receptor for IgE. Immunol. Rev. 125: 77-79.
• DEL PRETE G., MAGGI E., ROMAGNANI S. 1994. Human Thl and Th2 cells: functional properties, mechanisms of regulation and role in disease. Lab. Invest. 70: 299-306.
• DE MELLO D. E., LIAPIS H., JUREIDINI S., NOURI S., KEPHART G. M., GLEICH G. J. 1990. Cardiac localization of eosinophil-granule major basie protein in acute necrotizing myocarditis. N. Engl L. Med. 323: 1542-1545.
• DENT LĀ., MUNRO G. H., PIPER K. P., SANDERSON C. J., FINLAY D. A., DEMPSTER R. K., BIGNOLD L. P., HARKIN D. G., HAGAN P. 1997. Eosinophilic interleukin 5 (IL-5) transgenic mice: eosinophil activity and impaired clearance of Schistosoma mansoni. Parasite Immunol. 19:291-300.
• DE PATER-HUIJES F. L., POMPEN M., JANSEN H. M., OUT T. A. 1997. Products from mast cells influence T lymphocyte proliferation and cytokine production - relevant to allergic asthma? Immunol. Latters 57: 47-51.
• DESREUMAUX P., CAPRON M. 1996. Eosinophils in allergic reactions. Curr. Opin. Immunol. 8: 790-795.
• DUNNE D. W., BUTTERWORTH A. E., FULFORD A. J. C., KARILTKI H. C., LANGLEY J. G., OUMA J. H., CAPRON A., PIERCE R. J., STURROCK R. F. 1992. Immunity after treatment of human schistosomiasis mansoni: association between IgE antibodies to adult worm antigens and resistance to reinfection. Eur. J. Jmmunol. 22: 1483-1494.
• DVORAK A. M. 1997. New aspects of mast cell biology. Jnt. Archiv. Allergy. Immunol. 114: 1-9.
• EBISAWA M., YAMADA T., BICKEL C., KLUNK D., SCHLEIMER R. P. 1994. Eosinophil transendothelial migration induced by cytokines. III. Effect of chemokine RANTES. J. Immunol. 153: 2153-2160.
• ELOVIC A. E., OHYAMA H., SAUTY A., MCBRIDE J., TSUJJ. T., NAGAI M., WELLER P. F., WONG D. T. W. 1998. IL-4 -dependent regulation of TGF-α and TGF-β1 expression in human eosinophils. J. Immunol. 160: 6121-6127.
• ELSE K. J., FINKELMAN F. D. 1998. Intestinal nematode parasites, cytokines and effector mechanisms. Int. J. Parasitol. 28: 1145-1158.
• FACCIOLI L. H., NOURSHARGH S., MOOBEL R., WILLIAMS F. M., SEHMI R., KA Y A. B, WILLIAMS T. J. 1991. The accumulation of "'In-eosinophils induced by inflammatory mediators, in vivo. Immunology 73: 222-227.
• - MOKWA V. F., SILVA C. L, ROCHA G. M., ARAUJO J. L, NAHORI M. A., YARGAFTIG B. B. 1996. IL-5 drives eosinophils from bone marrow to blood and tissues in a guinea-pig model of visceral larva migrans syndrome. Mediators Inflamm. 5: 24-31.
• FATTAH D. L, MAIZELS R. M, MCLAREN D. J., SPRY C. J. 1986. Toxocara cams: interaction of human blood eosinophils with the infective larvae. Exp. Parustiol. 61: 421-431.
• FOLKARD S. G., HOGARTH P. J., TAYLOR M. J., BIANCO A. E. 1996. Eosinophils are the major effector cells of immunity to microfilariae in a mouse model of onchocerciasis. Parasitology 112: 323-329.
• FOX C. C., JEWELL S. D., WHITACRE C. C. 1994. Rat peritoneal mast cells present antigen to PPD-specific T cell line. Cell Immunol. 158: 253-259.
• FRANDJI. P., TKACZYK C., OSKERITZIAN C. 1995. Cytokine-dependent regulation of MHC class II expression and antigen presentation ofmast cells. Cellular Immunol. 163: 37-41.
• FUJJSAWA T., ABU-GHAZALEH R., KITA H., SANDERSON C. J., GLEICH G. J. 1990. Regulatory effect of cytokines on eosinophil degranulation. J. Immunol. 144: 642-646.
• GANSMULLER A., ANEUNIS A., VENTURIELLO S. M., BRISCHI F., BIANGHI R. A. 1987. Antibodydependent in vitro cytotoxicity of newborne Trichinella spiralis larvae: nature of the cells involved. Parasite Immunol. 9: 281-292.
• GLAUERT A. M, LAMMAS O.A., DUFFUS W. P. H. 1985. Ultrastructural observatioris on the interaction between bovine eosinophils and juvenile Fasciola hepatica. Parasitology 91 :459-470.
• GLEICH G. J., ADOLPHSON C. R. 1986. The eosinophil leukocyte: structure and function (Review) Adv. Immunol. 39: 177-253.
• - LAMMAS D. A., HERLICH H. 1977. The effect of antiserum to eosinophils on susceptibility and acquired immunity of the guinea-pig to Trichostrongylus colubriformis. Immunology 37: 373- 380.
• GORDON J. R., GALLI S. J. 1991. Release of both performed and newly synthesized tumour necrosis factor alpha (TNF-α)/cachectin by mouse mast cell stimulated via the FcεRI. A mechanism for the sustained action of mast cell-derived TNF-α during IgE-dependent biological responses. J. Exp. Med. 174: 103-107.
• - 1994. Promotion of mouse fibroblast collagen gene expression by mast cells stimulated via RcεRI. Role for mast cell-derived transforming growth factor β and tumour necrosis factor α. J. Exp. Med. 180: 2027-2037.
• GOUNNI A. S., LAMKHLOUED B., OCHIAI K., TANAKA Y., DELAPORTE E., CAPRON A, KINET J-P., CAPRON M. 1994. High-affinity IgE receptor on eosinophils involved in defence against parasites. Nature 367: 183-185.
• GREENE B. M., TAYLOR H. R, AIKAWA M. 1981. Cellular killing of microfilaria of Onchocerca volvulus: eosinophil and neutrophil-mediated immune serum-dependent destruction. J. Immunol. 127: 1611-1618.
• GRENCIS R. K„ HULTNER L., ELSE K. J. 1991. Host protective immunity to Tnchinella spiralis in mice: activation of Th cells subsets and lymphokine secretion in mice expressing different response phenotypes. Immunology 74: 329-332.
• - 1997. Th2-mediated host protective immunity to intestinal nematode infections. Philos. Trans. R. Soc. Land B 352: 1377-1384.
• GROVE D. L, MAHMOUD A. A., WARREN K. S. 1977. Eosinophils and resistance to Tnchinella spiralis. J. Exp. Med. 145: 755-759.
• HAGAN P., BLUMENTHAL V. J, DUNN D., SIMPSON A. J. G., WILKINS H. A. 1991. Human IgE, IgG4 and resistance to the reinfection with Schistosoma haematobium. Nature. 349: 243-245.
• HARTNELL A., KAY A. B., WARDLAW A. J. 1992. IFN-y induces expression of FcyRIII (CD 16) on human eosinophils. J. Immunol. 148: 1471-1475.
• HENDERSON G. S., CONARY J. T., SUMMAR M., MCCURLEY T. L., COLLEY D. G. 1991. In vivo molecular analysis of lymphokines involved in the murine immune response during Schistosoma mansoni infection. J. Immunol. 147: 992-996.
• HERDON F. J., KAYES S. G. 1992. Depletion of eosinophils by anti-IL-5 monoclonal antibody treatment of mice infected with Trichinella spiralis does not alter parasitic burden or immunologie resistance to reinfection. J. Immunol. 149: 3642-3647.
• HORIE S., GLEICH G. J., KITA H. 1996. Cytokines directly induce degranulation and superoxide production from human eosinophils. J. Allerg. Clin. Immunol. 98: 371-381.
• HUNTLEY J. F., SCHALLIG H. D. F. H., KOOYMAN F. N. J., MACKELLAR A., JACKSON F., SMITH W. D. 1998. IgE antibody during infection with the ovine abomasal nematode, Teladorsagia cierumcincta: primary and secondary responses in serum and gastric lymph of sheep.Parasite Immunol. 20: 565-571.
• IHLE J. N., WITTHUHN B. A., QUELLE F. W., YAMAMOTO K., SILYENNOINEN O. 1995. Signalling through the hematopoietic cytokine receptors. Ann. Rev. Immunol. 13: 369-398.
• ISHIARA C., OCHJAI K., KAGAMI M., TAKAHASHI H., MATSUYAMA G., YOSHIDA S. TOMIOKA H., KOY A N. 1997. Human peripheral eosinophils express functional interferon-gamma receptors (IFN-yR). Clin. Exp. Immunol. 110: 524-529.
• JARRETT E. E. E., BAZIN H. 1974. Elevation of total serum IgE in rats following helminth parasite infection. Nature 251:613-614.
• - MILLER H. R. P.1982. Production and activities of IgE in helminth infection. Prog. Allergy 31: 178-233.
• JURGOWIAK M., OLIŃSKI R. 1995. Wolne rodniki a starzenie się. Kosmos 44: 71-88.
• KANEKO M., HITOSHI Y., TAKATSU K., MATSUMOTO S. 1991. Role of interleukin-5 in local accumulation of eosinophils in mouse allergic peritonitis. Int. Arch. Allergy. Appl. Immunol. 96: 41-45.
• - SUANSOS M. C., GLEICH G. J., KITA H. 1995. Allergen-specific IgG1 and IgG3 through Fe gamma RII induce eosinophil degranulation. J. Clin. Invest. 95: 2813-2818.
• KEPHART G. G., GLEICH G. J., CONNOR D. H., GIBSON D. W., ACKERMAN S. J. 1984. Deposition of eosinophil granule major basie protein onto microfilariae of Onchocerca volvulus in the skin of patients treated with diethycabamazine. Lab. Invest. 50: 51-61.
• KHALIFE J., CAPRON M., GRZYCH J-M., BAZIN H., CAPRON A. 1985. Extracellular release of rat eosinophil peroxidase (EPO) I. Role of anaphylactic immunoglobulins. J. Immunol. 134:1968-1974.
• KIMATA H., YOSHIDA A., ISHIOKA C., LINDLEY I., MIKAWA H. 1992. Interleukin 8 (IL-8) selectively inhibits immunoglobulin E production induced by IL-4 in human B cells. J. Exp. Med. 176: 1227-1231.
• KITA H., WEILER D. A., ABU-GHAZALEH R, SANDERSON C. J., GLEICH G. J. 1992. Release of granule proteins from eosinophils cultured with IL-5. J. Immunol. 149: 629-635.
• KORENAGA M., T ADA I. 1994. The role of IL-5 in the immune responses to nematodes in rodents. Parasitol. Today 10: 234-235.
• KORSGREN M., PERSSON C. G. A., SUNDLER F., BJERKE T., HANSSON T., CHAMBERS B. J., HONG S., VAN KAER L., LJUNGGREN H-G, KORSGREN O. 1999. Natural killer cells determine development of allergen-induced eosinophilic airway inflammation in mice. J. Exp. Med. 189: 553-562.
• LEE T. D.G. 1991. Helminthotoxic responses of intestinal eosinophils to Trichinella spiralis newborn larvae. Infect. Immunity 59: 4405-4411.
• LOPEZ A. F., ELLIOT M. J., WOODCOCK J, VADAS M. A. 1992. GM-CSF, IL-3 and IL-5; crosscompetition on human hemopoietic cells. Immunol. Today 13: 495-500.
• MAHANTY S., LUKE H. E., KUMARASWAMI V., NARAYANAN P. R., VIJAYSHEKARAN V., NUTMAN T. B. 1996. Stage-specific induction of cytokines regulates the immune response in lympatic filariasis. Exp. Parasitol. 84: 282-290.
• MAIZELS R. M., BUNDY D. A. P., SELKIRK M. E., SMITH D. F., ANDERSON R. M. 1993. Immunological modulation and evasion by helminth parasites in human populations. Nature 365: 797-805.
• MASINOYSKY B., URDAL D., GALLATIN W. M. 1990. IL-4 acts synergistically with IL-1β to promote lymphocyte adhesion to microvascular endothelium by inductuion of vascular cell adhesion molecule-1. J. Immunol. 145: 2886-2895.
• MEHLORTA R. K., HALL L. R., HIGGINS A. W. 1998. Interleukin-12 suppress filaria-induced pulmonary eosinophilia, deposition of major basie protein and airway hyperresponsiveness. Parasite Immunol. 20: 455-462.
• MCLAREN D. J, MCKEAN J. R., OLSSON I., VENGE P., KA Y A. B, 1984. Schistosoma mansoni, further studies of the interaction between schistosomula and granulocyte-derived cationic proteins in vitro. Parasitology 88: 491-503.
• MICHAELE., BUNDY D. A. P. 1997. Global mapping of lymphatic filariasis. Parasitol. Today 3: 472-476.
• MILLER H. R. P. 1996. Mucosal mast cells and the allergic response against nematode parasites. Vet. Immunol. Immunopathol. 54: 331-336.
• MOSMANN T. R., COFFMAN R. L. 1989. Th1 and Th2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol. 7: 145-173.
• MOUNTFORD A., PEARLMAN E. 1998. Interleukin-12 and the host response to parasitic helminths; the paradoxical effect on protective immunity and immunopathology. Parasite Immunol. 20: 509-517.
• OSWALD I. P., GAZZINELLI R. T., SHER A., JAMES S. L. 1992. IL-10 synergizes with IL-4 and transforming growth factor - β to inhibit macrophage cytotoxic activity. J. Immunol. 148: 3578-3582.
• OTTESEN E. A., NUTMAN T. B. 1992. Tropical pulmonary eosinophilia. Annu. Rev. Med. 43: 417-424.
• PARKHOUSE R. M. E, CLARK N. W. T. 1983. Stage specific secreted and somatic antigens of Trichinella spiralis. Mol. Biochem. Parasitol. 9: 319-327.
• PAZDRAK K., STAFFORD S., ALAM R. 1995. The acivation of the Jak-STAT 1 signaling pathway by IL-5 in eosinophils. J. Immunol. 155: 397-402.
• PEARCE E. J., CASPAR P., GRZYCH J-M., LAWIS F. A., SHER A. 1991. Downregulation of Th1 cytokine production accompanies induction of Th2 responses by parasitic helminth, Schistosoma mansoni. J. Exp. Med. 173: 159-163.
• PEARLMAN E., HAZLETT F. J., BOOM W. H., KAZURA J. W. 1993a. Induction of murine T-helpercell responses to filarial nematode Brugia malayi. Infec. Immunity 61: 1105-111
• - HIGGINS A. W., BARDENSTAIN D. S. 1998. The role of eosinophils and neutrophils in helminthinduced keratitis. Invest. Opthal. Visual Sci. 39: 1176-1181.
• - KROEZE W. K, HAZLETT F. J., CHEN S. S, MAWHORTER S. D, BOOM W. H., KAZURA J. W. 1993b. Brugia malayi: acquired resistance to microfilariae in BALB/c mice correlates with local Th1 responses. Exp. Parasitol. 76: 200-208.
• PINCUS s. H., CAMMARATA P. V., DELIMA M., DESPOMMIER D. 1986. Eosinophilia in murine trichinellosis. J. Parasitol. 72: 321-325.
• POLLA B. S., COSSARIZZA A. 1996. Stress proteins in inflammation. In Stress-inducible Cellular Responses ed. by U. Feige, Morimoto Rl, Yahara I, Polia B. Brikhauser Verlag Basel/Switzerland.
• PRITCHARD D. I. 1993. Immunity to helminths: is too much IgE parasite-rather than host protective? Parasite Immunol. 15: 5-9.
• - QUINNELL R. J., WALSH E.A. 1995. Immunity in humans to Necator americanus: IgE, parasite weight and fecundity. Parasite Immunol. 17: 71-75.
• RAINBIRD M. A., MACMILLAN D., MEEUSEN E. N. T. 1998. Eosinophil-mediated killing of Haemonchus contortus larvae: effect of eosinophil activation and role of antibody, complement and interleukin-5. Parasite Immunol. 20: 93-103.
• ROMAGNANI S. 1992. Induction of TH1 and TH2 responses: a key role for the 'natural' immune response? Immunol. Today 13: 379-381.
• ROTHIENBERG M. E, OWEN W. F., SILBERTAIN D. S., WOODS J., SOBERMAN R. J, AUSTEN K. F., STEYENS R. L. 1988. Human eosinophils have prolonged survival, enhanced functional properties, and become hypodense when exposed to human interleukin 3. J. Clin. Invest. 81: 1986-1971.
• ROTMAN H. L, YUTANAWIB0ONCHAI W, BRIGANDI R. A.. 1996. Strongyloides stercoralis: eosinophil-dependent immune-mediated kiling of third stage larvae in BALB/cByJ. mice. Exp. Parasitol. 82: 267-278.
• SCEPEK S., LINDAU M. 1993. Focal exocytosis by eosinophils-compound exocytosis and cumulative fusion EMBO 12: 1811-1817.
• SCHROEDER J. M., Noso N., STICHERLING M., CHRISTOPHERS E. 1996, Role of eosinophilchemotactic C-C chemokines in cutaneous inflammation. J. Leukocyt. Biol. 59: 1-5.
• SCOTT P., PEARCE E., CHEYER A. W., COFFMAN R. L., SHER A. 1989. Role of cytokines and CD4+T cell subsets in the regulation of parasite immunity and disease. Immunol. Rev. 112:161-170.
• SELKIRK M. E., SMITH V. P., THOMAS G. R., GOUNARIS K. 1998. Resistance of filarial nematode parasites to oxidative stress. Int. J. Parasitol. 28: 1315-1332.
• SHAW R. J., GATEHOUSE T. K, MCNEGLL M. M. 1998. Serum IgE responses during primary and challenge infections of sheep with Trichostrongylus colubriformis. Int. J. Parasitol. 28: 293-392.
• SHER A., COFFMAN R. L. HIENY S., CHEEYER A. W. 1990a. Ablation of eosinophil and IgE responses with anti-IL-5 or anti-IL-4 antibodies fails to affect immunity against Schistosoma mansoni in the mouse. J. Immunol. 145: 3911-3916.
• - - - SCOTT P., OIEEVER A. W. 1990b. Interleukin-5 is required for the blood and tissue eosinophilia but not granuloma formation induced by infection with Schistotsoma mansoni. Proc. Natl. Acad. Sci. USA 87: 61-65.
• - FIORENTINO D., CASPAR P., PEARCE E., MOSMANN T. 1991. Production of IL-10 by CD4+T lymphocytes correlates with downregulation of Th1 cytokines synthesis in helminth infection. J. Immunol. 147: 2713-2716.
• SILLABER C., GEISSLER K., SCHERRER R., KALTENBRUNNER R., BETTELHEIM P., LECHNER K., VALENT P. 1992. Type β transforrning growth factors promote interlrukin-3 (IL-3) dependent differentiation of human basophils but inhibit IL-3-dependent differentiation of human eosinophils. Blood 80: 634-639.
• SIMON HU, BLASE K. 1995. Inhibition of programmed eosinophil death: a key pathogenic event for eosinophilia. Immunol. Today 16: 53-55.
• - YOUSEFI S., SCHRANZ C., SCHAPOWAL A., BACHERT C., BLASER K. 1997. Direct demonstration of delayed eosinophil apoptosis as a mechanism causing tissue eosinophilia. J. Immunol. 158: 3902-3908.
• STERN M., MEAGHER L., SAVTL J., HASLETT C. 1992. Apoptosis in human eosinophils: programmed cell death in the eosinophil leads to phagocytosis by macrophages and is modulated by IL-5. J. Immunol. 148: 3543-3549.
• TAI P. C., SUN L., SPRY C. J. 1991. Etfects of IL-5, granulocyte/macrophage colony stimulating factor (GM-CSF) and IL-3 on the survival of human blood eosinophils in vitro. Clin. Exp.Immunol. 85: 312-316.
• TAYERNIER J., DEVOS R., CORNELIS S., TUYPENS T., VAN DER HEYDEN J., FIERS W., PLAETNICK G. 1991. A human high atfmity interleukin-5 receptor (IL5R) is composed of an IL5-specific chain and chain shared with the receptor for GM-CSF. Cell 66: 1175-1184.
• UCHIKAWA R., YAMADA M., MATSUDA S., KURODA A., ARIZONO N. 1994. IgE antibody production is associated with suppressed interferon-y levels in mesenteric lymph nodes of rats infected with the nematode Nippostrongylus brasiliensis. Immunology 82: 427-432.
• URBAN J. F., Jr, KATONA I. M., PAUL W. E., FINKELMAN F. D. 1991. Interleukin 4 is important in protective immunity to a gastrointestinal nematode infection in mice. Proc. Natl. Acad. Sci. USA 88: 5513-5517.
• VALERIUS T., REPP R., KALDEN J. R., PLATZER E. 1990, Etfects of IFN-y on human eosinophils in comparison with other cytokines. Novel class of eosinophil activators with delayed onset of action. J. Immunol. 145: 2950-2955.
• VENTURIELLO S. M., GIAMBARTOLOMEI G. H., COSTANTINO S. N. 1993. Immune killing of newborn Trichinella larvae by human leukocytes. Parasite Immunol. 15: 559-564.
• VISSERS M. C., STERN A., KUYPERS F., VAN DEN BERG J., WINTERBOURN C. C. 1994. Membrane changes associated with lysis of red blood cells by hypochlorous acid. Free Radic. Biol. Med. 16: 703-712.
• WAKELIN D. 1993. Allergic inflammation as a hypothesis for the expulsion of worms from tissue. Parasitol. Today 9: 115-116.
• WALLEN N., KITA H., WEILER D., GLEICH G. J. 1991. Glucocorticoids inhibit cytokine-mediated eosinophil survival. J. Immunol. 147: 3490-3495.
• WALSH G. M., HARNELL A., WARDLAW A. J., KURJHARA K., SANDERSON C. J., KAY A. B. 1990. IL-5 enhances the in vitro adhesion of human eosinophils, but not neutrophils, in a leukocyte integrin (CDI 1/18)- dependent manner. Immunology 71: 258-265.
• WANG J. M., RAMBALDI A., BIONDI A., CHEN Z. G., SANDERSON C. J., MANTOYANI A. 1990. Recombinant human interleukin 5 is a selective eosinophil chemoattractant. Eur. J. Immunol. 19: 701-705.
• WASTLING J. M., SCUDAMORE C. L., THORNTON E. M., NEWLANDS G. F. J. MILLER H. R. P. 1997. Constitutive expression of mouse mast cell protease-1 in normal BALB/c mice and its upregulation during intestinal nematode infection. Immunology 90: 308-313.
• WEDI B., RAAP U., LEWRICK H., KAPP A. 1998. IL-4 induced apoptosis in peripeheral blood eosinophils. J. Aller. Clin. Immunol. 102: 1013-1020.
• WELLER P. F. 1991. The immunobiology of eosinophils. N Engl. J. Med. 324: 1110-1118.
• WILIAMS C. M., COLEMAN J. W. 1995. Induced expression of mRNA for IL-5, IL-6, TNF-a, MIP-2 and INF-y in immunologically activated rat peritoneal mast cell: inhibition by dexamethasone and cyclosporin A. Immunology 86: 244-249.
• WODNAR-FILIPOWICZ A., HEUSSER G. H., MORONI C. 1989. Production of hematopoietic growth factors GM-CSF and interleukin-3 by mast cells in response to IgE receptor-mediated activation. Nature 339: 150-152.
• YAMAGUCHI Y., HAYASHI Y., SUGAMA Y., MIURA Y., KASAHARA T., KITAMURA S., TORISU M., MITA S., TOMINAGA A., TAKATSU K., SUDA T. 1988a Highly purified murine interleukin 5 (IL-5) stimulates eosinophil function and prolongs in vitro survival. IL-5 as an eosinophil chemotactic factor. J. Exp. Med. 167: 1737-1742.
• - SUDA T., SUDA J., EGUCHI M., MIURA Y., HARADA N., T0MINAGA A., TAKATSU K 1988b. Purified interleukin 5 (IL-5) supports the terminal differentiation and proliferation of murine eosinophilic precursors. J. Exp. Med. 167: 43-56.
• - - OHTA S., TOMINAGA K., MIURA Y., KASAHARA T. 1992. Analysis of the survival of mature human eosinophils: interleukin-5 prevents apoptosis in mature human eosinophils. Blood 78: 2542-2547.
• YOSHIMURA K., UCHIDA K., SATO K., OYA H. 1984. Ultrastructural evidence for eosinophilmediated destruction of Angiostrongylus cantoniensis transfered into the pulmonary artery of non-permissive host. Parasite Immunol. 6: 105-118.
• YOUSEFI S., BLASER K., SIMON H-U. 1997. Activation of signaling pathways and prevention of apoptosis by cytokines in eosinophils. Int. Arch. Allergy. Immunol. 112: 9-12.