Melatonin and its precursors L-tryptophan prevent acute gastric mucosal damage induced by aspirin in humans

• Autorzy: Konturek P.C. , Celinski K. , Slomka M. , Cichoz-Lach H. , Burnat G. , Naegel A. , Bielanski W. , Konturek J.W. , Konturek S.J.
• Języki publikacji: EN

Abstrakty

EN

Melatonin (MT) and its precursor L-tryptophan (Trp) are implicated in the protection of gastric mucosa against noxious agents. However, the role of MT and Trp on the gastric mucosal injury induced by aspirin (ASA) in human has not been investigated. Studies in animals showed that both MT and Trp given intragastrically prevents the formation of gastric mucosal lesions induced by ASA. The aim of the present study was to determine the influence of MT and Trp given orally to healthy humans on gastric mucosal lesions induced by ASA. The present study included 21 healthy, Hp-negative male volunteers with intact gastro-duodenal mucosa aging 20-50 yr. They were divided in 3 groups; group1: 7 volunteers receiving daily 2 x 1g ASA (Polfa, Rzeszow) during 11 days; group 2: 7 healthy volunteers receiving 2x1g ASA and MT (Lekam, Zakroczyn) (5 mg 30 min prior to ASA) during 11 days and group 3: 7 healthy volunteers receiving 2x1g ASA and Trp (Ardeytropin, Germany) (0.5 g 30 min prior to ASA) during 11 days. Mucosal damage was evaluated at 3rd, 7th and 11th days of ASA administration by endoscopy using Lanza score. Plasma melatonin was measured using RIA and gastric mucosal generation of PGE2 was assessed also by RIA. ASA caused marked mucosal injury at all days of its administration except day 11th when only moderate lesions were evident. Pre-treatment with MT or Trp alone was accompanied by a significant decrease in gastric mucosal lesion score. Gastric mucosal generation of PGE2 was suppressed by about 90% in subjects treated with ASA without or with MT or Trp. We concluded that: MT and its precursor Trp significantly attenuate gastric mucosal lesions induced by aspirin. The action of Trp may be be mediated by MT produced in gastrointestinal tract from Trp. The gastroprotective action of MT and Trp is independent on gastric mucosal PGE2 generation.

Słowa kluczowe

EN

man; melatonin; L-tryptophan; gastric mucosal injury; gastric mucosa; aspirin; gastric mucosal damage

• Wydawca: -
• Czasopismo: Journal of Physiology and Pharmacology. Supplement
• Rocznik: 2008
• Tom: 59
• Numer: 2
• Opis fizyczny: p.67-75,fig.,ref.

Twórcy

autor

Konturek P.C.

• University Erlangen-Nuremberg, Erlangen, Nuremberg 18, 91054 Erlangen, Germany

autor

Celinski K.

autor

Slomka M.

autor

Cichoz-Lach H.

autor

Burnat G.

autor

Naegel A.

autor

Bielanski W.

autor

Konturek J.W.

autor

Konturek S.J.