Interleukina 6 w hodowlach neurofilow i komorek jednojadrzastych oraz surowicy krwi pacjentow w przebiegu boreliozy z Lyme

• Autorzy: Jablonska E. , Puzewska W. , Marcinczyk M. , Hermanowska-Szpakowicz T.
• Języki publikacji: PL

Abstrakty

PL

Oceniano zdolność neutrofílów i komórek jednojądrzastych do uwalniania interleukiny 6 (IL-6) w porównaniu z jej poziomem w surowicy krwi osób z boreliozą z Lyme i osób zdrowych. Uzyskane wyniki wskazują, że zarówno neurofile jak i komórki jednojądrzaste mogą wpływać na reakcje kontrolowane przez IL-6 u badanych pacjentów.

EN

The aim of this study was to estimate the release of IL-6 by human neutrophils (PMN) and peripheral blood mononuclear cells (PBMC) in patients with Lyme disease confronted with the serum levels. The cells were isolated from whole blood of 25 patients and of 10 healthy donors and cultured in the presence of LPS. In the culture supernatants and serum the concentration of IL-6 with ELISA (BioSource) were measured. In patients we observed higher values of IL-6 released by unstimulated PMN and PBMC in compared with control. In contrast to control, we didn't observe increased the release of IL-6 by LPS-stimulated PMN and PBMC as compared to unstimulated cells. In the serum of patient we found increased the concentration of IL-6. The higher ability of PMN and PBMC from patients with Lyme disease to release of IL-6 and the lack response to additional stimulation indicate the activation of PMN and PBMC in vivo.

Słowa kluczowe

PL

surowica krwi; neurofile; choroby czlowieka; pacjenci; komorki jednojadrzaste; borelioza; ludzie zdrowi; interleukina 6; ludzie chorzy

• Wydawca: -
• Czasopismo: Medycyna Doświadczalna i Mikrobiologia
• Rocznik: 2003
• Tom: 55
• Numer: 1
• Opis fizyczny: s.81-87,tab.,bibliogr.

Twórcy

autor

Jablonska E.

• Akademia Medyczna, Bialystok

autor

Puzewska W.

autor

Marcinczyk M.

autor

Hermanowska-Szpakowicz T.

Bibliografia

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