The influence of ethanol on magnesium body status

• Autorzy: Pacewicz T , Moniuszko-Jakoniuk J. , Brzoska M.M.
• Języki publikacji: EN

Abstrakty

EN

Magnesium (Mg) is the second most important intracellular cation that is needed for a broad variety of physiological functions. Disturbances in Mg body status, which may be induced by environmental contaminants, life style and manner of nutrition, can create serious negative consequences for health. One of the factors affecting Mg homeostasis is excessive ethanol consumption. Interactions between ethanol and Mg can take place at different stages of Mg metabolism (absorption, distribution in the organism and excretion of this element) as well as at the stage of its biological functions. Ethanol ingestion leads to serious disturbances in Mg metabolism on the one hand, while dietary Mg intake has been reported to influence the metabolism and toxicity of ethanol on the other. Experimental data show that Mg supplementation may prevent or reduce adverse effects of ethanol action in animals, whereas its deficiency can intensify ethanol toxicity. In this review, the interactions between ethanol and Mg in humans and animals are discussed on the basis of the available clinical, epidemiological and experimental data, against the background of common ethanol consumption and insufficient Mg dietary intake in the general population.

• Wydawca: -
• Czasopismo: Polish Journal of Environmental Studies
• Rocznik: 2008
• Tom: 17
• Numer: 4
• Opis fizyczny: p.447-456,fig.,ref.

Twórcy

autor

Pacewicz T

• Medical University of Bialystok, Mickiewicza 2c str.,15-222 Bialystok, Poland

autor

Moniuszko-Jakoniuk J.

autor

Brzoska M.M.

Bibliografia

• 1. PAPIERKOWSKI A. Importance of magnesium in clinical practice. Part I. Causes and symptoms of magnesium dysbalance. Med. Rodz. 17, 31, 2002 [In Polish].
• 2. RUBENOWITZ E., AXELSSON G., RYLANDER R. Magnesium in drinking water and death from acute myocardial infarction. Am. J. Epidemiol. 143, 456, 1996.
• 3. DURLACH J. New data on the importance of gestational Mg deficiency. J. Am. Coll. Nutr. 23, 694, 2004.
• 4. JOHNSON S. The multifaceted and widespread pathology of magnesium deficiency. Med. Hypotheses 56, 163, 2001.
• 5. SHANE S. R., FLINK E. B. Magnesium deficiency in alcohol addiction and withdrawal. Magnesium Trace Elem. 10, 263, 1992.
• 6. PASTERNAK K., KIEŁCZYKOWSKA M. Alcoholism, drug addiction and macro- and microelements in experimental and clinical studies. Alkohol. i Narko. 16, 25, 2003 [In Polish].
• 7. MARZEC Z. Evaluation of copper, zinc, iron, magnesium intake and their correlation with other parameters in adult food rations. Biul. Magnezol. 4, 371, 1999 [In Polish].
• 8. YANG CH. Y., CHIU H. F. Calcium and magnesium in drinking water and the risk of death from hypertension. Am. J. Hyper. 12, 894, 1999.
• 9. PEACOCK J. M., FOLSOM A. R., ARNETT D. K., ECKFELDT J. H., SZKLO M. Relationship of serum and dietary magnesium to incident hypertension: the atherosclerosis risk in communities (ARIC) study. Ann. Epidemiol. 9, 159, 1999.
• 10. MURAWSKA B., SPYCHAJ-FABISIAK E., JANOWIAK J. The influence of natural and antrophogenic factors on magnesium leaching from soils. Biul. Magnezol. 6, 607, 2001 [In Polish].
• 11. KOZŁOWSKA J. Effect and after-effect of sulfur fertilization and liming on magnesium contents and uptake by plants. Biul. Magnezol. 6, 287, 2001 [In Polish].
• 12. DOMAŃSKA J. The content of Ca and Mg in plants depending on kind of soil, pH and application Cd and Pb. Biul. Magnezol. 6, 135, 2001 [In Polish].
• 13. BRZÓSKA M. M., MONIUSZKO-JAKONIUK J., JURCZUK M., GAŁAŻYN-SIDORCZUK M., ROGALSKA J. Effect of short-term ethanol administration on cadmium retention and bioelement metabolism in rats continuously exposed to cadmium. Alcohol Alcohol. 35, 439, 2000.
• 14. FLORA S. J. S., KUMAR D., SACHAN S. R. S., GUPTA S. D. Combined exposure to lead and ethanol on tissue concentration of essential metals and some biochemical indices in rat. Biol. Trace Elem. Res. 28, 157, 1991.
• 15. MOON J. The role of vitamin D in toxic metal absorption: a review. J. Am. Coll. Nutr. 13, 559, 1994.
• 16. SOLDATOVIC D., MILIC S. Mg concentration in serum of workers occupationally exposed to lead. Symp. Intern. Magn. Path. Hum., Vittel ed., pp. 569-572, 1973.
• 17. KARCZEWSKI J., STEFAŃSKA E. Evaluation of occupational exposure to lead on the basis of magnesium content in the hair. Biul. Magnezol. 5 (1), 22, 2000 [In Polish].
• 18. WÓJCIK A., BRZESKI Z. Some chosen heavy metals in the state of acute alcohol intoxication and alcohol disease. Polish J. Environ. Stud. 6 (Suppl.), 199, 1997.
• 19. SARIS N. E. L., MERVAALA E., KARPPANEN H., KHAWAJA J., LEWENSTAM A. Magnesium. An update on physiological, clinical and analytical aspects. Clin. Chim. Acta 294, 1, 2000.
• 20. ANASTASSOPOULOU J., THEOPHANIDES T. Magnesium - DNA interactions and the possible relation of magnesium to carcinogenesis. Irradiation and free radicals. Crit. Rev. Oncol. Hemat. 42, 79, 2002.
• 21. MARCINKOWSKA-SUCHOWIERSKA E. Magnesium metabolism in the health and illness. Post. Nauk Med. 4, 86, 1991 [In Polish].
• 22. MCLEAN M. R. Magnesium and its therapeutic uses: a review. Am. J. Med. 96, 63, 1994.
• 23. VORMANN J. Magnesium: nutrition and metabolism. Mol. Aspects Med. 24, 27, 2003.
• 24. RUDE R. K., GRUBER H.F. Magnesium deficiency and osteoporosis: animal and human observations. J. Nutr. Biochem. 15, 710, 2004.
• 25. DURLACH J. Importance and clinical forms of chronic primary magnesium deficiency in human beings. Magnesium Res. 14, 83, 2001.
• 26. MEYER C., RUMPF H. J., HAPKE U., DILLING H., JOHN U. Prevalence of alcohol consumption, abuse and dependence in a country with higher per capita consumption: findings from the German TACOS study. Transitions in Alcohol Consumption and Smoking. Soc. Psychiatry Psychiatr. Epidemiol. 35, 539, 2000.
• 27. QUERTEMONT E., TAMBOUR S., TIRELLI E. The role of acetaldehyde in the neurobehavioral effects of ethanol: a comprehensive review of animal studies. Prog. Neurobiol. 75, 247, 2005.
• 28. ALTURA B. M., ALTURA B. T. Association of alcohol in brain injury, headaches, and stroke with brain tissue and serum levels of ionized magnesium: a review of recent findings and mechanisms of action. Alcohol 19, 119, 1999.
• 29. NIEDWOROK E., WARDAS M., STEC M., DOŁOWY M. Determination of the peroxidation process of lipids modified by magnesium ions and ethanol in isolated rat hepatocytes. Now. Lek. 71, 295, 2002 [In Polish].
• 30. TREVISIOL C. H., TURNER R. T., PFAFF J. E., HUNTER J. C., MENAGH P. J., HARDIN K., HO E., IWANIEC U. T. Impaired osteoinduction in a rat model for chronic alcohol abuse. Bone 41, 175, 2007.
• 31. THURMAN R. G., BRADFORD B. U., IIMURO Y., FRANKENBERG M. V., KNECHT K. T., CONNOR H. D., ADACHI Y., WALL C., ARTEEL G. E., RAIEIGH J. A., FORMAN D. T., MASON R. P. Mechanism of alcoholinduced hepatotoxicity: studies in rats. Front. Biosci. 4, 42, 1999.
• 32. RUKKUMANI R., ARUNA K., SURESH-VARMA P., MENON V. P. Influence of ferulic acid on circulatory prooxidant-antioxidant status during alcohol and PUFA induced toxicity. J. Physiol. Pharmacol. 55, 551, 2004.
• 33. CEFARATTI CH., YOUNG A., ROMANI A. Effect of ethanol administration on Mg²⁺ transport across liver plasma membrane. Alcohol 36, 5, 2005.
• 34. LIEBER C. S. Alcoholic liver injury: pathogenesis and therapy. Pathol. Biol. 49, 738, 2001.
• 35. KOCUR J. Concentration of bioelements in alcohol dependent patients. Biul. Magnezol. 2, 239, 1997 [In Polish].
• 36. MUSSALO-RAUHAMAA H., POIKOLAINEN K., KÄRKKÄINEN P., LEHTO J. Decreased serum selenium and magnesium levels in drunkenness arrestees. Drug Alcohol Depen. 20, 95, 1987.
• 37. KUCHARSKA-MAZUR J. Alcoholic liver injuries and bioelements. Biul. Magnezol. 3, 139, 1998 [in Polish].
• 38. FLINK E. B., STUTZMAN F. L., ANDERSON A. R., KONIG T., FRASER R. Magnesium deficiency after prolonged parenteral fluid administration and after chronic alcoholism complicated by delirium tremens. J. Lab. Clin. Med. 43, 169, 1954.
• 39. BABU A. N., CHENG T. O. P., ZHANG A., ALTURA B. T., ALTURA B. M. Low concentrations of ethanol deplete type-2 astrocytes of intracellular free magnesium. Brain Res. Bull. 50, 59, 1999.
• 40. ELISAF M., MERKOUROPOULOS M. Pathogenetic mechanisms of hypomagnesaemia in alcoholic patients. J. Trace Elem. Med. Biol. 9, 210, 1996.
• 41. YOUNG A., CEFARATTI CH., ROMANI A. Chronic EtOH administration alters liver Mg2+ homeostasis. Am. J. Physiol. Gastrointest. Liver Physiol. 284, G57, 2003.
• 42. GULLESTAD L., DULVA L. O., SOYLAND E., MANGER A. T., FALCH D., KJEKSHUS J. Oral magnesium supplementation improves metabolic variables and muscle strength in alcoholics. Alcohol. Clin. Exp. Res. 16, 986, 1992.
• 43. WOLD L. E., NORBY F. L., HINTZ K. K., COLLIGAN P. B., EPSTEIN P. N., REN J. Prenatal ethanol exposure alters ventricular myocyte contractile function in the offspring of rats. Cardiovasc. Toxicol. 1, 215, 2001.
• 44. BROWN R. A., CRAWFORD M., NATAVIO M., PETROVSKI P., REN J. Dietary magnesium supplementation attenuates ethanol-induced myocardiac dysfunction. Alcohol. Clin. Exp. Res. 22, 2062, 1998.
• 45. AAGAARD N. K., ANDERSEN H., VILSTRUP H., CLAUSEN T., JAKOBSEN J., DORUP I. Magnesium supplementation and muscle function in patients with alcoholic liver disease: A randomized, placebo-controlled trial. Scand. J. Gastroentero. 40, 972, 2005.
• 46. PACH J., TARGOSZ D., KAMENCZAK A. The usefulness of Aspargin for supplementing potassium and magnesium in ethanol dependent patients. Przeg. Lek. 56, 472, 1999 [In Polish].
• 47. KRISHEL S., SAFRANEK D., CLARK R. F. Intravenous vitamins for alcoholics in the emergency department: a review. J. Emerg. Med. 16, 419, 1998.
• 48. MONIUSZKO-JAKONIUK J., JURCZUK M., GAŁAŻYN - SIDORCZUK M., BRZÓSKA M. M. Lead turnover and changes in the body status of chosen micro- and macroelements in rats exposed to lead and ethanol. Polish J. Environ. Stud. 12, 335, 2003.
• 49. MAILLOT F., FARAD S., LAMISSE F. Alcohol and nutrition. Pathol. Biol. 49, 683, 2001 [in French].
• 50. PITTS T. O., VAN THIEL D. H. Disorders of divalent ions and vitamin D metabolism in chronic alcoholism. Recent Dev. Alcohol 4, 357, 1986.
• 51. KUCHARSKA-MAZUR J., OGOŃSKI T., ZAWIERTA J., NOCEŃ I. 1997. The effect of alcohol dependence course on magnesium, calcium and iron concentration in plasma. Biul. Magnezol. 2, 88, 1997 [in Polish].
• 52. PASTERNAK K., MĄDRO R., CZEKAJSKA-ŁUCKIEWICZ H. Magnesium and calcium concentrations in blond serum of human after a single dose of various alcoholic beverages. Biul. Magnezol. 4, 149, 1999 [in Polish].
• 53. PASTERNAK K. Tissue concentrations of magnesium in rats receiving various dosages of ethanol. Magnesium Res. 12, 167, 1999.
• 54. PASTERNAK K., PAPIERKOWSKI A., FLORIAŃCZYK B., MŁYNARCZYK M. Magnesium concentration in tissues and blood serum of narcotized mice. Biul. Magnezol. 2, 62, 1996 [In Polish].
• 55. TESSMAN P. A., ROMANI A. Acute effect of EtOH on Mg²⁺ homeostasis in liver cells: evidence for the activation of an Na⁺/Mg²⁺ exchanger. Am. J. Physiol. 275 (5 Pt 1), G1106, 1998.
• 56. CHURCH M. W., JEN K. L. C., PELLIZZON A., HOLMES P. A. Prenatal cocaine, alcohol and undernutrition differentially alter mineral and protein content in fetal rats. Pharmacol. Biochem. Beh. 59, 577, 1998.
• 57. MCDONALD J. T., MORGEN S. Wine versus ethanol in human nutrition III. Calcium, phosphorus, and magnesium balance. Am. J. Clin. Nutr. 32, 823, 1979.
• 58. FLINK E. B., SHANE S. R., SCOBBO R. R., BLEHSCHMIDT N., MCDOWELL P. Relationship of free fatty acids and magnesium in ethanol withdrawal in dogs. Metabolism 28, 858, 1979.
• 59. PAL R., NATH R., GILL K. D. Influence of ethanol on cadmium accumulation and its impact on lipid peroxidation and membrane bound functional enzymes (Na⁺, K⁺ -ATPase and acetylcholinesterase) in various regions of adult rat brain. Neurochem. Invest. 23, 451, 1993.
• 60. YOUNG A., BERTI-MATTERA L., ROMANI A. Effect of repeated doses of ethanol on hepatic Mg²⁺ homeostasis and mobilization. Alcohol. Clin. Exp. Res. 31, 1240, 2007.
• 61. EISENHOFER G., LAMBIE D. G., WHITESIDE E. A., JOHNSON R. H. Vasopressin concentrations during alcohol withdrawal. Brit. J. Addict. 80, 195, 1985.
• 62. MÜTZELL S. Cardiovascular and some biochemical effects of high alcohol consumption. Upsala J. Med. Sci. 93, 227, 1988.
• 63. MAJDANIK S., BOROWIAK K., OROWICZ W. Postmortem examination of some microelementary agents in urine drunk victims. Biul. Magnezol. 6, 594, 2001 [In Polish].
• 64. CHOI M. J., KIM M. J., CHANG K. J. The effect of dietary taurine supplementation on plasma and liver lipid concentrations and mineral metabolism in rats fed alcohol. Adv. Exp. Med. Biol. 583, 243, 2006.
• 65. KREUSSER W., KURAKAWA K., AZNAR E., SACHTJEN E., MASSRY S. G. Effect of phosphate depletion on magnesium homeostasis in rats. J. Clin. Invest. 61, 573, 1978.
• 66. WITTE K. K. A., CLARK A. L., CLELAND J. G. F. Chronic heart failure and micronutrients. J. Am. Coll. Card. 37, 1765, 2001.
• 67. BROWN R. A., ILG K. J., CHEN A. F., REN J. Dietary Mg²⁺ supplementation restores impaired vasoactive responses in isolated rat aorta induced by chronic ethanol consumption. Eur. J. Pharmacol. 442, 241, 2002.
• 68. LI W., ZHENG T., ALTURA B. T., ALTURA B. M. Antioxidants prevent depletion of [Mg²⁺]i induced by alcohol in cultured canine cerebral vascular smooth muscle cells: possible relationship to alcohol-induced stroke. Brain Res. Bull. 55, 475, 2001.
• 69. EMA M., GEBREWOLD A., ALTURA B. T., ALTURA B. M. Magnesium sulfate prevents alcohol-induced spasms of cerebral blood vessels: an in situ study on the brain microcirculation from male versus female rats. Magnesium Trace Elem. 10, 269, 1992.
• 70. BIRCH R. M., WALKER G. M. Influence of magnesium ions on heat shock and ethanol stress responses of Saccharomyces cerevisiae. Enzyme Microb. Tech. 26, 678, 2000.