Impairment of testicular endocrine and exocrine functions after dieldrin exposure in adult rats

• Autorzy: Hallegue D , Rhouma K.B. , Tebourbi O. , Sakly M.
• Języki publikacji: EN

Abstrakty

EN

In this study we examined the mechanism of action of Dieldrin on the reproductive function in adult male rats. Experimental data suggest that exposure to pesticide at 3 and 6mg/kg/day for 10 consecutive days, induced a dose-dependant decrease of the number and the mobility of epididymal spermatozoa. Tes­ticle histological analysis shows alteration of spermatogenesis with marked reduce of gametes production combined with reduction in the seminiferous tubule diameters in treated relative to control. Concentration of plasma testosterone dropped significantly in a dose-dependent manner after exposure to Dieldrin, while circulating levels of Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH) and weight of accessory sex glands were not affected significantly. Thus, it may be concluded that Dieldrin exposure can impair both testicle gametogenesis and steroidogenesis in adult rats.

Słowa kluczowe

EN

adult rat; fertility; pesticide; immune system dysfunction; rat; neurological defect; genital system; health problem; carcinogenic process; male; risk; spermatozoon; reproductive function; testosterone

• Wydawca: -
• Czasopismo: Polish Journal of Environmental Studies
• Rocznik: 2003
• Tom: 12
• Numer: 5
• Opis fizyczny: p.557-561,fig.

Twórcy

autor

Hallegue D

• Laboratory of Physiology and Biochemical Environmental, Bizerta-Jarzouna 7021, Tunisia

autor

Rhouma K.B.

autor

Tebourbi O.

autor

Sakly M.

Bibliografia

• 1. ADAMI H. Testicular cancer in nine Northern European countries. Int. J. Cancer. 59, 33, 1994.
• 2. AUGER J., KUNSTMANN J.M., CZYGLIK F., JOUAN- NET P. Decline in semen quality of fertile men during the last 20 years. N. Engl. J. Med. 332, 281, 1995.
• 3. CARLSEN E., GIWERCMANNA., KEIDING N., SKAK- KEBAEK N. Evidence for decreasing quality of semen dur­ing past 50 years. Br. Med. J. 305, 609, 1992.
• 4. MULTIGNER L;, THONNEAU P., DUCOT B., CLAVERT A., SPIRA A. Pesticides and male fertility. Current knowl­edge and epidemiological approach. In: Hamamah S, Mie- usset R (Eds). Research in male gametes: production and quality, pp.159-165. 1996
• 5. World Health Organization. Aldrin and dieldrin., Environ­mental Health Criteria, N° 91, Geneva, 1989.
• 6. MEISTER R., WILLOUGHBY O.H., MEISTER Publish­ing. ed. Farm chemicals handbook, 1989.
• 7. DAVIES J.E, Neurotoxic concerns of human pesticide expo­sure. Am. J. Ind. Med. 18, 327, 1990.
• 8. HOFFMAN W. Organochlorine compounds: Risk of non- Hodgkin's lyphoma and breast cancer. Arch..Environ. Health. 51, 189, 1996.
• 9. GRAHAM M.J., WILLIAMS F.M., RAWLINS M.D. Me­tabolism of aldrin to dieldrin by rat skin following topical application. Food. Chem. Toxicol. 29, 707, 1991.
• 10. WADE M.G., DESAULNIERS D., LEINGARTNER K., FOSTER W.G. Interactions between endosulfan and diel­drin on estrogen-mediated progresses in vitro and in vivo. Reprod. Toxicol. 11, 791, 1997.
• 11. VANIO H., PARKKI M.G. Enhancement of microsomal monooxygenase, epoxide hydrase and UDPglucuronyltrans- ferase by aldrin, dieldrin and isosafrole administrations in rat liver. Toxicology. 5, 279, 1976.
• 12. HOPP PC, PITTS S. Fertilization in vitro and development of mouse ova. Biol. Reprod. 8, 420, 1973.
• 13. BLUS L, CROMARTIE E, MC NEASE L, JOANEN T. Brown Pelican: population status, reproductive success and organochlorine residues in Louisiana (1971-1976). Bull. Envir. Contam. Toxicol. 22, 128, 1979.
• 14. OBENWALD I.T., HASSAN M.Q., STOHS S.J. Die un­fruchtbare generation. Chancen. 2, 20, 1989.
• 15. MABLY T.A., BJERKE D.L., MOOR R.W., GENDRON-FITZPATICK A., PETERSON R.E. In utero and lactational exposure of male rats to 2,3,7,8-tetrachlorodibenzeno-p-di- oxin. 3. Effects on spermatogenesis and reproductive capa­bility. Toxico. Appl. Pharmacol. 74, 118, 1992.
• 16. BEN RHOUMA K., TEBOURBI O., KRICHAH R., SAKLY M. Reproductive toxiciy of DDT in adult male rats. Hum. Exp. Toxicol. 20, 393, 2001.
• 17. RIVERO-RODRIGUEZ L., BORJA-ABURTO V.H., SAN- TOS-BURGOA C., WALISZEWSKIY S., RIOS C., CRUZ V. Exposure assessment for workers applying DDT to con­trol malaria in veracruz, Mexico. Environ. Health. Perspect. 105, 98, 1997.
• 18. Dalsenter PR, Faqi AS, Chahoud I. Serum testosterone and sexual behavior in rats after prenatal exposure to lindane. Bull.Environ. Contam.Toxicol. 59, 360, 1997.
• 19. ZIRKIN B.R., SANTULLI R., AWONIYI C.A., EWING L.L. Maintenance of advanced spermatogenic cells in the adult rat testis: quantitative relationship to testosterone concentration within the testis. Endocrinology. 124, 3043, 1989.
• 20. GLASS R.I., LYNESS R.N., MENGLE D.C., POWELL K.E., KAHN E. Sperm count depression in pesticide ap­plicators exposed to dibromo-chloropropane. Am. J. Epide­miol. 109, 346, 1979.
• 21. KRAUSE W. Influence of DDT, DDPV and malathion on FSH, LH and testosterone serum levels and testosterone concentration in testis. Bull. Envir. Contam. Toxicol. 18, 231, 1977.
• 22. CHATTERJEE S., RAY A., GHOSG S., BHATTACHARYA K., PAKRASHI A., DEB C. Effect of aldrin on spermatogenesis, plasma gonadotrophins and testosterone, and testicular testosterone in the rat. J. Endocrinol. 119, 75, 1988.
• 23. HALL J.L., FENG Y.L. Effect of kepon exposure on the reproductive Parametrs of the male rat. 16th World Congress on Fertility and Sterility and 54th Annual Meeting of the American Society for Reproductive Medecine. San Fran­cisco 4-9 October; 1998.
• 24. PINO-LATAILLADE G., THOREUX-MANLAY A., COF- FIGNY H., MASSE R., SOUFIR J.C. Reproductive toxicity of chronic lead exposure in male and female mice. Hum. Exp. Toxicol. 14, 872, 1995.
• 25. LAFUENTE A., MARQUEZ N., POUSADA Y., PAZO D., ESQUIFINO A.I. Possible estrogenic and/or antiandrogenic effects of methoxychlor on prolactin release in male rats. Arch. Toxicol. 74, 270, 2000.
• 26. AKINGBEMI B.T., REN-SHAN G.E., KLINEFELTER G.R., GUNSALUS G.L., HARDY M.P. A metabolite of methoxychlor, 2,2-Bis (p-Hydroxyphenyl)-1,1,1-trichloro- ethane, reduces testosterone biosynthesis in rat leydig cells through Suppression of steady-state messenger ribonucleic acid levels of the cholesterol side-chain cleavage enzyme. Biol. Reprod. 62, 571, 2000.
• 27. GELLERT R.J., HEINRICHS W.L., SWERDLOHH R. DDT homologues: estrogen-like effects on the vagina, uterus and pituitary of the rat. Endocrinology. 91, 1095, 1972.
• 28. WEINBAUER G.F., BARLETT J.M., FINGSCHEID U., TSONIS C.G., DE KRETSER D.M., NIESCHLAG E. Evi­dence for a major role o inhibin in the feedback control of FSH in the male rat. J. Reprod. Fertil. 85, 355, 1989.
• 29. BANBINO T.H., HSUEH A.J.W. Direct inhibitory effect of glucocorticoids upon testicular luteinizing hormone recep­tor and steroidogenesis in vivo and in vitro. Endocrinology. 108, 2142, 1981.
• 30. MOORADIAN A.D., MORLEY J.E., KORENMAN S.G. Biological actions of androgens. Endocrinol. Rev. 8, 1, 1987.
• 31. DALTON D.P., LEE C., HUPRIKA S., CHMIEL J.S., GRAYHACK J.T. Non-androgenic role of testis in enhanc­ing ventral prostate growth of rats. Prostate. 16, 225, 1990.