Effect of coal dusts containing heavy metals on the structure, cellular enzymatic markers, and cytochrome P-450-dependent monooxygenase system in rat kidneys

• Autorzy: Trzeciak H. I. , Kaminski M. , Plewka A. , Malecki A. , Pudelko A.
• Języki publikacji: EN

Abstrakty

EN

We evaluated morphological changes, the activities of succinate dehydrogenase, lactate dehydrogenase, glucoso-6-phosphatase, Mg2+-dependent adenosine triphosphatase, and acid phosphatase, and the activity of the cytochrome P-450-dependent monooxygenase system in rat kidneys exposed to coal dusts containing either low or high amounts of heavy metals. We showed that the coal dust with a very low content of heavy metals (VLCHM) did not produce any structural lesions, but significantly increased the activities of the enzymes. These changes probably reflected kidney adaptation to unfavorable conditions caused by the metals. The interactions among them reduced the eventual nephrotoxic effect of their action. The coal dust with high content of heavy metals (HCHM) damaged proximal convoluted tubules, straight tubules, and, to a lesser degree, distal convoluted tubules, especially those of long-looped nephrones. The levels and the activities of the assayed cytochromes decreased significantly in the kidneys of rats exposed to HCHM coal dust.

Słowa kluczowe

EN

enzymatic marker; monooxygenase; coal dust; kidney; cytochrome P450; rat; heavy metal

• Wydawca: -
• Czasopismo: Polish Journal of Environmental Studies
• Rocznik: 1995
• Tom: 04
• Numer: 4
• Opis fizyczny: p.75-82,fig.,ref.

Twórcy

autor

Trzeciak H. I.

• Silesian Academy of Medicine, Medykow 18, 40-752 Katowice-Ligota, Poland

autor

Kaminski M.

autor

Plewka A.

autor

Malecki A.

autor

Pudelko A.