Dopamine D2 receptor gene polymorphism and body mass

• Autorzy: Wlodarczyk M , Jarosz A. , Nowicka G.

Warianty tytułu

PL

Polimorfizm genu receptora D2 dopaminy a masa ciala

• Języki publikacji: EN

Abstrakty

EN

Dopamine plays a role in the regulation of appetite. Polymorphism in dopamine receptor gene may influence obesity development by their potential impact on dopamine reward function. The aim of the study was to investigate prevalence of TaqI A D2 dopamine receptor genotypes in relation to degree of obesity. Polymorphic variants of DRD2 gene was determined by PCR-RFLP method in 266 subjects. The A1 allele and the A1 allele containing genotypes were more frequent in the obese subjects than in non-obese subjects (43% vs. 14% for A1A1; 40% vs. 35% for A1A2; 32% vs 22% for A1 allele, respectively). Our findings are in line with the hypothesis of the involvement of gene implicated in dopamine regulation in development of obesity.

PL

Dopamina odgrywa kluczową rolę w regulacji apetytu. Uważa się, że poprzez wpływ na czynność układu nagrody w centralnym systemie nerwowym, wariant genu receptora D2 dopaminy może mieć związek z rozwojem otyłości. Celem badania była analiza polimorfizmu receptora D2 dopaminy oraz jego relacji z indeksem masy ciała (BMI). Polimorfizm genu DRD2 u 266 osób oznaczano metodą PCR (Polymerase Chain Reaction), a produkty reakcji poddawano trawieniu przez enzym restrykcyjny TaqI. Obserwowano większą częstość występowania allelu A1 i genotypów zawierających allel A1 u osób otyłych w porównaniu do osób z prawidłową masą ciała (43% vs. 14% dla A1A1; 40% vs. 35% dla A1A2; 32% vs. 22% dla allelu Al). Opisane wyniki wskazują na związek masy ciała oraz genu DRD2 układu dopaminergicznego.

Słowa kluczowe

PL

DNA polymorphism; dopamine D2 receptor; gene polymorphism; body mass; obesity; appetite; obesity degree; obesity development

• Wydawca: -
• Czasopismo: Żywienie Człowieka i Metabolizm
• Rocznik: 2009
• Tom: 36
• Numer: 4
• Opis fizyczny: p.615-621,fig.,ref.

Twórcy

autor

Wlodarczyk M

• National Food and Nutrition Institute, Powsinska 61/63, 02-903 Warsaw, Poland

autor

Jarosz A.

autor

Nowicka G.

Bibliografia

• 1. Barnard N.D., Noble E.P., Ritchie T., et al.: D2 dopamine receptor Taq1A polymorphism, body weight, and dietary intake in type 2 diabetes. Nutrition 2009, 25, 58.
• 2. Blum K., Braverman E.R., Wood R.C., et al.: Increased prevalence of the Taq I A1 allele of the dopamine receptor gene (DRD2) in obesity with comorbid substance use disorder: a preliminary report. Pharmacogenetics 1996, 6, 4, 297.
• 3. Blum K., Chen T.J., Meshkin B., et al.: Reward deficiency syndrome in obesity: a preliminary cross-sectional trial with a Genotrim variant. Adv. Ther., 2006, 23, 6, 1040.
• 4. Comings D.E., Flanagan S.D., Dietz G., et al.: The dopamine D2 receptor (DRD2) as a major gene in obesity and height. Biochem. Med. Metab. Biol., 1993, 50, 2, 176.
• 5. Comings D.E., Gade R., MacMurray J.P., et al.: Genetic variants of the human obesity (OB) gene: association with body mass index in young women, psychiatric symptoms, and interaction with the dopamine D2 receptor (DRD2) gene. Mol. Psychiatry 1996, 1, 4, 325.
• 6. Davis C., Levitan R.D., Kaplan A.S., at al.: Reward sensitivity and the D2 dopamine receptor gene: A case-control study of binge eating disorder. Prog. Neuropsychopharmacol. Biol. Psychiatry 2008, 1, 32, 3, 620.
• 7. Epstein L.H., Temple J.L., Neaderhiser B.J., et al.: Food reinforcement, the dopamine D2 receptor genotype, and energy intake in obese and nonobese humans. J. Behav. Neurosci., 2007, 121, 5, 877.
• 8. Epstein L.H., Wright S.M., Paluch R.A., et al.: Relation between food reinforcement and dopamine genotypes and its effect on food intake in smokers. Am. J. Clin. Nutr., 2004, 80, 1, 82.
• 9. Grandy D.K., Litt M., Allen L., et al.: The human D2 receptor gene is located on chromosome 11 at q22-q23 and identifies a TaqI RFLP. Am. J. Hum. Genet., 1989, 45, 778.
• 10. Grandy D.K., Zhang Y., Civelli O.: PCR detection of the TaqA RFLP at the DRD2 locus. Hum. Mol. Genet., 1993, 2, 12, 2197.
• 11. Hoebel B.G.: Brain neurotransmitters in food and drug reward. Am. J. Clin. Nutr., 1985, 42, 5, 1133.
• 12. Kelley A.E., Schiltz C.A., Landry C.F.: Neural systems recruited by drug- and food-related cues: studies of gene activation in corticolimbic regions. Physiol. Behav., 2005, 15, 86, 1, 11.
• 13. Noble E.P.: D2 dopamine receptor gene in psychiatric and neurologic disorders and its phenotypes. Am. J. Med. Genet. B Neuropsychiatr. Genet., 2003, 116, 1, 103.
• 14. Noble E.P., Noble R.E., Ritchie T., et al.: D2 dopamine receptor gene and obesity. Int. J. Eat Disord., 1994, 15, 3, 205.
• 15. Noble E.P., St Jeor S.T., Ritchie T., et al.: D2 dopamine receptor gene and cigarette smoking: a reward gene? Med. Hypotheses 1994, 42, 4, 257.
• 16. Rankinen T., Zuberi A., Chagnon Y.C., et al.: The human obesity gene map: the 2005 update. Obesity (Silver Spring), 2006, 14, 529.
• 17. Seeman P., Bzowej N.H., Guan H.C., et al.: Human brain D1 and D2 dopamine receptors in schizophrenia, Alzheimer.s, Parkinsonʼs, and Huntingtonʼs diseases. Neuropsychopharmacology 1987, 1, 1, 5.
• 18. Sieminska A., Buczkowski K., Jassem E., et al.: Influences of polymorphic variants of DRD2 and SLC6A3 genes, and their combinations on smoking in Polish population. BMC Med. Genet., 2009, 17, 10, 92.
• 19. Small D.M., Gregory M.D., Mak Y.E., et al.: Dissociation of neural representation of intensity and affective valuation in human gustation. Neuron 2003, 14, 39, 4, 701.
• 20. Spitz M.R., Detry M.A., Pillow P., et al.: Variant alleles of the D2 dopamine receptor gene and obesity. Nutr. Res., 2000, 20, 371.
• 21. Szczypka M.S., Kwok K., Brot M.D., et al.: Dopamine production in the caudate putamen restores feeding in dopamine-deficient mice. Neuron 2001, 30, 3, 819.
• 22. Wang G.J., Volkow N.D., Logan J., et al.: Brain dopamine and obesity. Lancet 2001, 3, 357, 9253, 354.