7-nitroindazole enhances amphetamine-evoked dopamine release in rat striatum. An in vivo microdialysis and voltammetric study

• Autorzy: Nowak P. , Brus R. , Oswiecimska J. , Sokola A. , Kostrzewa R.M.
• Języki publikacji: EN

Abstrakty

EN

The intracellular second messenger nitric oxide (NO) is implicated in a variety of physiological functions, including release and uptake of dopamine (DA). In the described study, in vivo microdialysis and differential pulse voltammetric techniques were used to determine the involvement of NO in release of DA and its metabolites (dihydroxyphenylalanine, DOPAC; homovanillic acid, HVA) in neostriatum of freely moving rats. While the NO donor molsidomine (30.0 mg/kg; MOLS) and neuronal NO synthase- (nNOS-) inhbitor 7-nitroindazole (10.0 mg/kg; 7-NI) had no effect on the basal in vivo microdialysate level of DA, 7-NI specifically enhanced D,L-amphetamine- (1.0 mg/kg i.p.; AMPH) evoked release of DA. Basal or AMPH effects on DOPAC and HVA levels were not influenced by MOLS or 7-NI. Findings indicate that nitrergic systems have an important role in mediating effects of AMPH on dopaminergic systems.

Słowa kluczowe

EN

neostriatum; microdialysis; molsidomine; 7-nitroindazole; brain; homovanillic acid; nitric oxide; dopamine; amphetamine; in vivo; voltammetry; rat

• Wydawca: -
• Czasopismo: Journal of Physiology and Pharmacology
• Rocznik: 2002
• Tom: 53
• Numer: 2
• Opis fizyczny: p.251-263,fig.

Twórcy

autor

Nowak P.

• Medical University of Silesia, H.Jordana 38 St., 41-808 Zabrze, Poland

autor

Brus R.

autor

Oswiecimska J.

autor

Sokola A.

autor

Kostrzewa R.M.