Liver and serum antioxidant status after methanol intoxication in rats

• Autorzy: Skrzydlewska E. , Farbiszewski R.
• Języki publikacji: EN

Abstrakty

EN

Activities of superoxide dismutase (SOD), catalase, glutathione peroxidase (GSH-Px) and glutathione reductase (GSSG-R) and concentration of ascorbate, a-tocopherol, non-protein and protein-bound sulfhydryi compounds and thio- barbituric acid-reactive substances (TBA-rs) were measured in liver and serum of rats 6, 12 and 24 h and 2, 5 and 7 days after intoxication with 1.5 g or 3.0 g methanol/kg b.w. Liver GSH-Px and GSSG-R activities and SH-groups and ascorbate content were significantly diminished at 6 and 24 h, while TBA-rs were increased. Serum SOD, GSH-Px and GSSG-R activities and SH-groups concentration were reduced while TBA-rs were elevated. The changes were more intensive after application of the higher dose of methanol. It is concluded that methanol impairs the liver and blood serum antioxidant mechanisms in rats.

Słowa kluczowe

EN

alpha-tocopherol; blood serum; thiobarbituric acid; methanol intoxication; sulphydryl compound; liver; ascorbate; rat; methanol toxicity; antioxidative enzyme

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 1997
• Tom: 44
• Numer: 1
• Opis fizyczny: p.139-145

Twórcy

autor

Skrzydlewska E.

• Medical Academy, 15-230 Bialystok 8, PO Box 14, Poland

autor

Farbiszewski R.

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