Evolution and resistance expression of MRSA. Evaluation of beta-lactam antibiotics against a set of isogenic strains with different types of phenotypic expression

• Autorzy: Asada K. , Inaba Y. , Tateda-Suzuki E. , Kuwahara-Arai K. , Ito T. , Hiramatsu K.
• Języki publikacji: EN

Abstrakty

EN

Methicillin-resistant Staphylococcus aureus (MRSA) has two mechanisms of resistance to P-lactam antibiotics; one is mediated by mecA gene expression, and the other by penicillinase production. It has been generally accepted in the clinical field that β-lactam antibiotics are not the drugs of choice for MRSA infection. In this report, however, ampicillin and penicillin G were shown to have relatively good activity against MRSA if combined with a β-lactamase inhibitor, sulbactam. These β-lactam antibiotics were found to have relatively high binding affinities to PBP2', the mecA-encoded MRSA-specific penicillin-binding protein. The possible therapeutic application of sulbactam/ampicillin against MRSA infection in combination with arbekacin, an aminoglycoside antibiotic newly developed and introduced into clinical use in Japan, is discussed.

Słowa kluczowe

EN

chemotherapy; methicillin; antibiotic; Staphylococcus aureus; ampicillin; penicillin

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 1995
• Tom: 42
• Numer: 4
• Opis fizyczny: p.517-524,fig.

Twórcy

autor

Asada K.

• Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo, Japan 113

autor

Inaba Y.

autor

Tateda-Suzuki E.

autor

Kuwahara-Arai K.

autor

Ito T.

autor

Hiramatsu K.

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