Controlled cholesterol efflux from the aortic smooth muscle cells triggers microheterogeneity of plasma membrane lipids and induces modification of the mitochondrial topology

• Autorzy: Tukaj C , Syta-Ksiazek E. , Zauszkiewicz A. , Drozd K. , Figarski A. , Spodnik J.H. , Wozniak M.
• Języki publikacji: EN

Abstrakty

EN

It is generally accepted that phospholipids of plasma membrane display lateral segregation into small microdomains commonly known as lipid rafts. Such lateral lipid organization is under the control of cholesterol. Cholesterol depletion evolved by methyl-β-cyclodextrin (MCD) has been found to induce further marked perturbation in lateral lipid organization, evidenced in the high field part of electron paramagnetic resonance spectra of plasma membranes labelled with a spectroscopic probe, namely 5-doxyl-stearic acid (5DOXS). Such perturbation of surface lipid topo-logy has been found to induce distinct changes in the mitochondrial morpho-logy, i.e. switch from filamentous form into small granular form. (Folia Morphol 2009; 68, 4: 244–246)

Słowa kluczowe

EN

controlled cholesterol efflux; cholesterol; aortic smooth muscle cell; trigger; microheterogeneity; plasma membrane; lipid; modification; mitochondrial topology; electron paramagnetic resonance; methyl-beta-cyclodextrin; mitochondrion; phospholipid; cell membrane; 5-doxyl-stearic acid

• Wydawca: -
• Czasopismo: Folia Morphologica
• Rocznik: 2009
• Tom: 68
• Numer: 4
• Opis fizyczny: p.244-246,fig.,ref.

Twórcy

autor

Tukaj C

• Medical University of Gdansk, Debinki 1, 80-211 Gdansk, Poland

autor

Syta-Ksiazek E.

autor

Zauszkiewicz A.

autor

Drozd K.

autor

Figarski A.

autor

Spodnik J.H.

autor

Wozniak M.

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