Czestosc wystepowania i lekoopornosc paleczek z rodziny Enterobacteriaceae izolowanych od pacjentow hospitalizowanych na oddzialach intensywnej terapii

• Autorzy: Rudnicka J. , Wroblewska M. , Marchel H. , Luczak M.

Warianty tytułu

EN

Comparison of frequency and susceptibility to antimicrobials of bacterial strains of the family Enterobactericeae isolated from patients hospitalised in intensive care units

• Języki publikacji: PL

Abstrakty

PL

Pacjenci hospitalizowani na oddziałach intensywnej terapii (OIT) są szczególnie narażeni na zakażenia wywołane przez bakterie oporne na wiele antybiotyków. Celem pracy była ocena częstości występowania i lekowrażliwości szczepów pałeczek Gram-ujemnych z rodziny Enterobacteriaceae izolowanych z materiałów klinicznych od tej grupy chorych, ze szczególnym uwzględnieniem profilu oddziału. Stwierdzono różnice w obrazie lekowrażliwości zależnie od rodzaju materialu klinicznego i profilu oddziału OIT.

EN

The aim of the study was estimation of frequency and susceptibility to antimicrobial agents of Gram-negative rods isolated from clinical specimens obtained from patients requiring intensive care, with emphasis on profile of the unit. The analysis comprised strains of Gram-negative rods isolated from patients of two intensive care units (ICUs) of a tertiary care hospital (1200 beds). Identification of cultured isolates was done using automated VITEK and API systems (bioMerieux, France). Susceptibility to antimicrobial agents was tested by a disk-diffusion method according to the NCCLS recommendations. In total the analysis comprised 722 strains of Gram-negative rods. In blood cultures predominated strains of Enterobacter spp. (42,5%) and Klebsiella pneumoniae (37,5%). In cultures of clinical specimens other than blood 41,6% comprised strains of Klebsiella pneumoniae, 14,8% Escherichia coli and 14,4% Proteus mirabilis. Frequency of multi-drug resistant strains of bacteria of the family Enterobacteriaceae was much higher among blood isolates in comparison to strains cultured from other clinical specimens. There was a relatively high percentage of strains of Enterobacteriaceae susceptible to piperacillin and tazobactam (69,0%) and ceftazidime(54,6%). Conclusions: 1. All strains were susceptible to carbapenems. 2. There was a relatively high percentage of strains of Gram- negative rods susceptible to piperacillin/tazobactam and ceftazidime. 3. Bacteria isolated from blood cultures were characterised by a much higher percentage of resistant strains in comparison to other specimens. 4. Longer stay in ICU promoted selection of strains resistant to antimicrobials.

Słowa kluczowe

PL

szpitale; pacjenci; oddzialy intensywnej terapii; infekcja bakteryjna; ryzyko zachorowan; Enterobacteriaceae; wystepowanie; opornosc na antybiotyki; wrazliwosc na leki

• Wydawca: -
• Czasopismo: Medycyna Doświadczalna i Mikrobiologia
• Rocznik: 2005
• Tom: 57
• Numer: 2
• Opis fizyczny: s.185-191,tab.,bibliogr.

Twórcy

autor

Rudnicka J.

• Samodzielny Publiczny Centralny Szpital Kliniczny Akademii Medycznej w Warszawie, ul.Banacha 1a, 02-097 Warszawa

autor

Wroblewska M.

autor

Marchel H.

autor

Luczak M.

Bibliografia

• 1. Baughman RP. Antibiotic resistance in the intensive care unit. Current Opinion Crit Care 2002; 8: 430-4.
• 2. Fridkin SK: Increasing prevalence of antimicrobial resistance in intensive care units. Crit Care Med 2001; 29 (4 Suppl ): N64-8.
• 3. Glupczynski Y, Delmee M, Goossens H, Straelens M. Belgian Multicenter ICU Study Group. Distribution and prevalence of antimicrobial resistance among Gram-negative isolates in intensive care units (ICU) in Belgian hospitals between 1996 and 1999. Acta Clin Belg 2001; 56: 297-306.
• 4. Hsueh PR, Liu YC, Yang D i inni. Multicenter surveillance of antimicrobial resistance of major bacterial pathogens in intensive care units in 2000 in Taiwan. Microb Drug Resist 2001; 7: 373-82.
• 5. Karpel E. Racjonalne stosowanie antybiotyków w oddziale intensywnej terapii. W: Zakażenia w intensywnej terapii. Urban & Partner, Wrocław, 2000,16-31.
• 6. Loeffler JM, Garbino J, Lew D i inni. Antibiotic consumption, bacterial resistance and their correlation in a Swiss university hospital and its adult intensive care units. Scand J Infect Dis 2003; 35: 843-50.
• 7. Luna CM, Gherardi C, Famiglietti A, lay C. Bacterial resistance and antimicrobial therapy in respiratory medicine and intensive care. Medicina 2001; 61: 603-13.
• 8. Mendes C, Hsiung A, Kiffer C i inni. MYSTIC Study Group. Evaluation of the in vitro ctivity of 9 antimicrobials against bacterial strains isolated from patients in intensive care units in Brazil: MYSTIC Antimicrobial Surveillance program. Braz J Infect Dis 2000; 4: 236-44.
• 9. Meyer E, Jonas D, Schwab F i inni. Design of a surveillance system of antibiotic use and bacterial resistance in German intensive care units (SARI). Infection 2003; 31: 208-15.
• 10. Silveira F, Fuijtani S, Paterson DL. Antibiotic-resistant infections in the critically ill adult. Clin Labor Med. 2004; 24: 329-41.
• 11. Singh AK, Sen MR, Anupurba S, Bhattacharya P. Antibiotic sensitivity pattern of the bacteria isolated from nosocomial infections in ICU. J Commun Dis 2002; 34: 257-63.
• 12. Wróblewska MM, MarcheI H, Łuczak M. Multidrug resistance in bacterial isolates from blood cultures of haematology patients. Internat J Antimicrob Agents 2002; 19: 237-40.