The influence of age and sex on selenium distribution and glutathione peroxidase activity in plasma and erythrocytes of selenium-adequate and supplemented rats

• Autorzy: Debski B , Zarski T.P. , Milner J.A.
• Języki publikacji: EN

Abstrakty

EN

The experiment was performed on Sprague-Dawley male rats weighing 203, 103 and 53 g, and female 99 g. Animals were fed for 2 weeks a diet containing 0,1 and 2,0 ppm of Se (Na₂ SeO₃ added). It was observed that the daily Se intake per kg of BW is lowered with an increase in animals body weight. Se-supplementation caused a significant increase of Se content in plasma and red blood cells. The highest concentration of Se in plasma and in RBC was found in females. GSH-Px activity was higher in RBC of all male rats receiving a Se-supplemented diet, but not in females. In plasma these differences between Se-adequate and supplemented rats were significant in youngest male rats and in females. These results suggest that age and sex of rats affect the concentration of Se and GSH-Px activity in plasma and RBC of rats.

Słowa kluczowe

EN

liver necrosis; plasma; erythrocyte; sex; liver; selenium; age; rat; glutathione peroxidase; mammalian cell

• Wydawca: -
• Czasopismo: Journal of Physiology and Pharmacology
• Rocznik: 1992
• Tom: 43
• Numer: 3
• Opis fizyczny: p.299-306

Twórcy

autor

Debski B

• Warsaw Agricultural University, Nowoursynowska 166, 02-766 Warsaw, Poland

autor

Zarski T.P.

autor

Milner J.A.

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