Nowe perspektywy w niefarmakologicznej terapii cukrzycy insulinoniezaleznej. Redukcja insulinoopornosci poprzez dietetyczne uwarunkowana modulacje triglicerydow miesni szkieletowych

• Autorzy: Rzeszutek-Desmond M

Warianty tytułu

EN

New perspectives in non-pharmacological therapy of non-insulin dependent diabetes mellitus. Reduction of insulin resistance through dietary-induced decrease in intramyocellular lipids

• Języki publikacji: PL

Abstrakty

PL

Niskotłuszczowe diety wegetariańskie wielokrotnie wykazywały wysoką skuteczność w terapii cukrzycy insulinoniezależnej w eksperymentach klinicznych w USA w ciągu ostatnich 30 lat. Mechanizm działania tych diet nie był jednak do końca jasny. W badaniu ufundowanym przez Amerykański Narodowy Instytut Zdrowia, przeprowadzonym na Uniwersytecie Georgea Waszyngtona w 2006 roku próbowano wyjaśnić przyczyny skuteczności tych diet. Udowodniono, że niskotłuszczowa dieta wegetariańska w znacznym stopniu przywraca wrażliwość na insulinę i redukuję HgAlC trzy razy bardziej efektywnie (średnio z 8% na 6,8%) niż tradycyjna dieta zalecana przez Amerykańskie Stowarzyszenie Osób Chorych na Cukrzycę (średnio z 8% na 7,6%). Zakłada się, że efekt ten jest spowodowany w dużej mierze znacznym zredukowaniem triglicerydów mięśni szkieletowych. Stopień redukcji tych triglicerydów jest zależny od poziomu tłuszczu w tego typu dietach. Jednocześnie wykazano, że stopień przestrzegania tego typu diet był wyższy niż tradycyjnej diety cukrzycowej. Wysoka skuteczność i akceptacja tych diet przez pacjentów sprawia, że stanowią one atrakcyjną alternatywę dla klasycznych niefarmakologicznych terapii cukrzycy.

EN

Low-fat vegetarian diets have proven highly effective in therapies of non-insulin dependent diabetes mellitus (NIDDM) in clinical trials from the last 30 years. However, the exact mechanism by which those diets exerted their effects remained unclear. A 2006 study funded by the US National Institute of Health, conducted by the medical staff of George Washington University, constituted an approach to elucidate the physiological effects of these diets on NIDDM. This study indicated that a low-fat vegetarian diet significantly improves glycaemic control and reduces hemoglobin A1c, three times more effectively (on average from 8,0% to 6,8 %) than the diet recommended by the American Diabetes Association (ADA) (from 8,0% to 7,6%). It is currently believed that this effect is mediated through significant reduction of intramyocellular lipids, which is achieved by low fat content in these diets. At the same time, it has been shown that the level of dietary compliance was higher in the low fat vegetarian group, than in the ADA group. Low-fat vegetarian diets represent an attractive alternative to conventional dietary therapies used in NIDDM, due to their high therapeutic efficiency combined with high patient acceptance.

Słowa kluczowe

PL

choroby czlowieka; cykrzyca insulinoniezalezna; leczenie; zywienie czlowieka; dieta niskotluszczowa; dieta wegetarianska; trojglicerydy; miesnie szkieletowe; opornosc na insuline; wrazliwosc na insuline

• Wydawca: -
• Czasopismo: Żywienie Człowieka i Metabolizm
• Rocznik: 2008
• Tom: 35
• Numer: 2
• Opis fizyczny: s.139-150,bibliogr.

Twórcy

autor

Rzeszutek-Desmond M

• Faculty of Health and Human Sciences, Thames Valley University in Dublin, Dublin, Ireland

Bibliografia

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