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2006 | 52 | 4 |

Tytuł artykułu

Poszukiwanie antygenow wzbudzajacych odpornosc przeciwko inwazjom tegoryjcow

Treść / Zawartość

Warianty tytułu

EN
Search for protective antigens of hookworms

Języki publikacji

PL

Abstrakty

EN
Hookworms are very important blood sucking nematode parasites of humans and domestic animals. The host with a heavy infection can lose almost a cup of blood per day. This may contribute to anemia which is associated with many physical and mental developmental insults. The works on obtaining an effective hookworm vaccine have been lasting for about eighty years. Recent identifications of a number of bioactive molecules produced by larval and adult stages of Ancylostomatidae are very helpful for selecting of nematode proteins crucial for host-parasite interactions and promising vaccine antigens. Many of these molecules are involved in host skin penetration by infective larvae, intestinal tissue invasion and digestion of haemoglobin and/or other macromolecular substrates. However, the results of many vaccination trials using recombinant forms of these proteins showed no sufficient protection against experimental hookworm infections.

Wydawca

-

Rocznik

Tom

52

Numer

4

Opis fizyczny

s.271-276,bibliogr.

Twórcy

autor
  • Szkola Glowna Gospodarstwa Wiejskiego, ul.Ciszewskiego 8, 02-786 Warszawa
autor
autor

Bibliografia

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  • [4] Otto G.F., Kerr K.B. 1939. The immunization of dogs against hookworm Ancylostoma caninum, by subcutanous injection of graded doses of larvae. American Journal of Hygiene 33(D): 23-27.
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  • [13] Zhan B., Hawdon J.M., Shan Q., Ren H.N., Qiang H.Q, Hu W., Xiao S.H., Li T.H., Gong X., Feng Z., Hotez P.J. 1999. Ancylostoma secreted protein-1 (ASP-1) homologues from human hookworms. Mole cular and Biochemical Parasitology 98: 143-149.
  • [14] Liu Sen., Ghosh K., Zhan B., Shan Q., Thompson G., Hawdon J.M., Koski A., Shuhua X., Hotez P.J. 2000. Hookworm burden reductions in BALB/c mice vaccinated with recombinant Ancylostoma secreted proteins (ASPs) from Ancylostoma duodenale, Ancylostoma caninum and Necator americanus. Vaccine 18: 1096-1102.
  • [15] Zhan B., Hotez P.J., Wang Y., Hawdon J.M., 2002. A developmental regulated metalloprotease secreted by host-stimulated Ancylostoma caninum third-stage infective larvae is a member of the astacin family of proteases. Molecular and Biochemical Parasitology 120: 291-296.
  • [16] Hotez P.J., Ashcom J., Zhan B., Bethony J., Loukas A., Hawdon J., Wang Y., Jin Q., Jones K.C., Dobardzic A., Dobardzic R., Bolden J., Essiet I., Brandt W., Russell P.K., Zook B.C., Howard B., Chacon M. 2003. Effect of vaccination with a recombinant fusion protein encoding an astacinlike metalloprotease (MTP-1) secreted by host-stimulated Ancylostoma caninum third-stage infective larvae. Journal of Parasitology 89: 853-855.
  • [17] Zhan B., Badamchian M., Bo M.H., Ashcom J., Feng J.J., Hawdon J., Xiao S.H., Hotez P.J. 2002. Molecular cloning and purification of Ac-TMP a developmentally regulated putative tissue inhibitor of metalloproteases released in relative abundance by adult Ancylostoma hookworms. American Journal of Tropical Medicine and Hygiene 66: 238-244.
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  • [20] Mieszczanek J., Harrison L.M., Vlasuk G.P., Cappello M. 2004. Anticoagulant peptides from Ancylostoma caninum are immunologically distinct and localize to separate structures within the adult hookworm. Molecular and Biochemical Parasitology 133: 319-342.
  • [21] Mieszczanek J., Harrison L.M., Cappello M. 2004. Ancylostoma ceylanicum anticoagulant peptide-1: role of the predicted reactive site amino acid in mediating inhibition of coagulation factors Xa and VIIa. Molecular and Biochemical Parasitology 137: 151-159.
  • [22] Chadderdon R.C., Cappello M. 1999. The hookworm platelet inhibitor: functional blockade of integrins GPIIb/IIIa (alphaIIbbeta3) and GPIa/Iia (alpha2beta1) inhibits platelet aggregation and adhesion in vitro. The Journal of Infectious Diseases 179: 1235-1241.
  • [23] Ali F., Brown A., Stanssens P., Timothy L.M., Soule H.R., Pritchard D.I. 2001. Vaccination with neutrophil inhibitory factor reduces the fecundity of the hookworm Ancylostoma ceylanicum. Parasite Immunology 23: 237-249.
  • [24] Milestone A.M., Harrison L.M., Bungiro R.D., Kuzmic P., Cappello M. 2000. A broad spectrum Kunitz type serine protease inhibitor secreted by the hook- worm Ancylostoma ceylanicum. The Journal of Biological Chemistry 275: 29391-29399.
  • [25] Chu D., Bungiro R.D., Ibanez M., Harrison L.M., Campodonico E., Jones B.F., Mieszczanek J., Kuzmic P., Cappello M. 2004. Molecular characterization of Ancylostoma ceylanicum Kunitz-type serine protease inhibitor: evidence for a role in hookworm-associated growth delay. Infection and Immunity 72: 2214-2221.
  • [26] Bungiro R.D., Green J., Kruglov E., Cappello M. 2001 Mitigation of hookworm disease by immunization with soluble extracts of Ancylostoma ceylanicum. The Journal of Infectious Diseases 183: 1380-1387.
  • [27] Bungiro R.D., Harrison L.M., Cappello M. 2002. Ancylostoma ceylanicum excretory/secretory protein 1: purification and molecular cloning of a major secretory protein from adult hookworms. Molecular and Biochemical Parasitology 119: 147-151.
  • [28] Munn E.A. 1977. A helical, polymeric extracellular protein associated with the luminal surface of Haemonchus contortus intestinal cells. Tissue Cell 9: 23-34.
  • [29] Munn E.A., Greenwood C.A., Coadwell W.J. 1987. Vaccination of young lambs by means of a protein fraction extracted from adult Haemonchus contortus. Parasitology 94: 385-397.
  • [30] Longbottom D., Redmond D.L., Russel M., Liddell S., Smith W.D., Knox D.P. 1997. Molecular cloning and characterization of a putative aspartate proteinase associated with gut membrane protein complex from adult Haemonchus contortus. Molecular and Biochemical Parasitology 88: 63-72.
  • [31] Redmond D.L., Knox D.P., Newlands G., Smith W.D., 1997. Molecular cloning of a developmentally regulated putative metallopeptidase present in a host protective extract of Haemonchus contortus. Molecular and Biochemical Parasitology 85: 77-87.
  • [32] Smith W.D., Smith S.K., Murray J.M. 1994. Protection studies with integral membrane fractions of Haemonchus contortus. Parasite Immunology 16: 231-241.
  • [33] Jones B.F., Hotez P.J. 2002. Molecular cloning and characterization of Ac-MEP-1, a developmentally regulated gut luminal metalloendopeptidase from adult Ancylostoma caninum hookworm. Molecular and Biochemical Parasitology 119: 107-116.
  • [34] Harrop S.A., Sawangjaroen N., Prociv P., Brindley P.J. 1995 Characterization and localization of cathepsin B proteinases expressed by adult Ancylostoma caninum hookworms. Molecular and Biochemical Parasitology 71: 163-171.
  • [35] Loukas A., Dowd A.J., Prociv P., Brindley P.J. 2000. Purification of a diagnostic, secreted cysteine protease-like protein from the hookworm Ancylostoma caninum. Parasitology International 49: 327-333.
  • [36] Harrop S.A., Prociv P., Brindley P.J. 1996. Acasp, a gene encoding a cathepsin D-like aspartic protease from the hookworm Ancylostoma caninum. Biochemical and Biophysical Research Communications 227: 294-302.
  • [37] Williamson A.L., Brindley P.J., Abbenante G., Prociv P., Berry C., Girdwood K., Pritchard D.I., Fairlie D.P., Hotez P.J., Dalton J.P., Loukas A. 2002. Cleavage of hemoglobin by hookworm cathepsin D aspartic proteases and its potential contribution to host specificity. The FASEB Journal 16: 1458-1460.
  • [38] Williamson A.L., Brindley P.J., Loukas A. 2003. Hookworm cathepsin D aspartic proteases: contributing roles in the host-specific degradation of serum proteins and skin macromolecules. Parasitology 126: 179-183.
  • [39] Williamson A.L., Brindley P.J., Abbenante G., Datu B.J.D., Prociv P., Berry C., Girdwood K., Pritchard D.I., Fairlie D.P., Hotez P.J., Zhan B., Loukas A. 2003. Hookworm aspartic protease, Na-APR-2, cleaves human hemoglobin and serum proteins in a hostspecific fashion. The Journal of Infectious Diseases 187: 484-94.
  • [40] Wiśniewski M., Zatorska A., Wędrychowicz H. 2004. Proteazy asparaginianowe tęgoryjców i ich biologiczna rola w układzie pasożyt - żywiciel. Medycyna Weterynaryjna 60: 808-811.
  • [41] Dalton J.P., Brindley P.J., Knox D.P., Brady C.P., Hotez P.J., Donnelly S., O'Neill S.M., Mulcahy G., Loukas A. 2003. Helminth vaccines: from mining genomic information for vaccine targets to systems used for protein expression. International Journal for Parasitology 33: 621-640.

Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

bwmeta1.element.agro-article-4583cf52-3190-4bf3-846a-bed21c3d0a7a
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