Angiotensin II - derived peptides devoid of phenylalanine in position 8 have full psychotropic activity of the parent hormone

• Autorzy: Holy Z , Braszko J. , Kupryszewski G. , Witczuk B. , Wisniewski K.
• Języki publikacji: EN

Abstrakty

EN

In this work we compared in rats the influence of heptapeptide 1-7-angiotensin II, hexapeptide 2-7-angiotensin II, pentapeptide 3-7-angiotensin II and angiotensin II on motility, stereotypy, learning of conditioned avoidance responses and recall of passive avoidance behaviour allowing to avoid aversive stimulation. The 4 peptides administered 15 min before the experiment, tended to increase the number of crossings, rearings and bar approaches in open field, significantly accelerated acquisition of conditioned avoidance responses and improved recall of the passive avoidance. All the peptides applied immediately before the experiment intensified stereotypy evoked by apomorphine in the dose 1 mg/kg and amphetamine in the dose 6.5 mg/kg given intraperitoneally. These results show full psychotropic activity of the examined fragments of angiotensin II, comparable with the activity of the parent octapeptide. Our previous hypothesis that the Val-Tyr-Ile-His-Pro fragment of angiotensin II is responsible for the psychotropic activity evoked by angiotensins in rats is thus confirmed.

Słowa kluczowe

EN

motor activity; psychotropic activity; phenylalanine; peptide; conditioned avoidance response; parent hormone; angiotensin; rat; passive avoidance; hormone

• Wydawca: -
• Czasopismo: Journal of Physiology and Pharmacology
• Rocznik: 1992
• Tom: 43
• Numer: 2
• Opis fizyczny: p.183-192,fig.

Twórcy

autor

Holy Z

• Medical Academy, 15-222 Bialystok, Mickiewicza 2c, Poland

autor

Braszko J.

autor

Kupryszewski G.

autor

Witczuk B.

autor

Wisniewski K.

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