The effect of a selective inhibition of potassium channels on the relaxation induced by nitric oxide in the human pregnant myometrium

• Autorzy: Modzelewska B , Kleszczewski T. , Kostrzewska A.
• Języki publikacji: EN

Abstrakty

EN

The aim of this study was to investigate whether apamin-sensitive K+ channels play a role in the NO induced relaxation of the human pregnant myometrium. Concentration-response curves for sodium nitroprusside (SNP) (10-9 – 10-4 M) were constructed in the absence and presence of 10-8 M apamin and 10-7 M charybdotoxin (CTX). Preincubation with apamin resulted in a significant attenuation of the relaxation caused by SNP, while pre-treatment with CTX insignificantly decreased the SNP induced relaxation. Our findings suggest that apamin-sensitive K+ channels exist in the human pregnant myometrium and play a role in modulation of the myometrium response to NO donors.

Słowa kluczowe

EN

pregnancy; man; myometrium; nitric oxide; potassium channel; smooth muscle

• Wydawca: -
• Czasopismo: Cellular and Molecular Biology Letters
• Rocznik: 2003
• Tom: 08
• Numer: 1
• Opis fizyczny: p.69-75,fig.

Twórcy

autor

Modzelewska B

• Medical University of Bialystok, Mickiewicza 2A, 15-230 Bialystok, Poland

autor

Kleszczewski T.

autor

Kostrzewska A.

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