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2002 | 54 | 3 |

Tytuł artykułu

Opornosc szczepow Staphylococcus aureus na czwartorzedowe sole amoniowe i chlorheksydyne

Warianty tytułu

Języki publikacji

PL

Abstrakty

PL
Badano poziom wrażliwości 90 szczepów Staphylococcus aureus izolowanych od pacjentów hospitalizowanych oraz pochodzących ze środowiska pozaszpitalnego na wybrane czwartorzędowe sole amoniowe i chlorheksydynę.
EN
The level of susceptibility of 90 different Staphylococcus aureus strains to chosen quaternary ammonium compounds: cetyltrimethyl ammonium bromide, benzalkonium chloride and benzethonium chloride as well as to chlorhexidine digluconate were examined. The examined strains consist of three groups: hospital originated MRSA, hospital originated MSSA and non-hospital MSSA. The significant differences between these groups were observed in they susccptibility to the investigated disinfectants. The obtained MIC values showed that the most resistant were hospital MRSA strains, where 55% was estimated as resistant to cetyltrimethyl amnonium bromide, 72% were resistant to benzalkonium chloride and benzethonium chloride and 7% were resistant to chlorhexidine digluconate. Among hospital originated MSSA 3% of strains were resistant to cetyltrimethyl ammonium bromide and 6% were resistant to benzalkonium chloride and benzethonium chloride. 14% non-hospital .S. aureus strains were resistant to benzalkonium chloride and benzethonium chloride. None were resistant to chlorhexidine digluconate or cetylthrimethyl ammonium bromide.

Wydawca

-

Rocznik

Tom

54

Numer

3

Opis fizyczny

s.191-197,tab.,bibliogr.

Twórcy

autor
  • Akademia Medyczna, Warszawa
autor

Bibliografia

  • 1. Bjorland J, Sunde M, Waage S. Plasmid-borne smr gene causes resistance to quaternary ammonium compounds in bovine Staphylococcus aureus. J Clin Microbiol 2001; 39: 3999-4004.
  • 2. Borges-Walmsley MI, Walmsley AR. The structure and function of drug pumps. Tri Microbiol 2001; 9: 71-79.
  • 3. Grkovic S. Brown MH, Roberts NJ i inni. QacR is a repressor protein that regulates expression of the Staphylococcus aureus multidrug efflux pump QacA. J Biol Chem 1998; 273: 18665-73.
  • 4. Heir E, Sundheim G, Holck AL. The Staphylococcus qacH gene product: a new member of SMR family encoding multidrug resistance. FEMS Microbiol Lett 1998; 163: 49-56.
  • 5. Heir E, Sundheim G, Holck AL. The qacG gene on plasmid pST94 confers resistance to tquaternary amonium compounds in staphylococci isolated from the food industry. J Appl Microbiol 1999; 86: 378-88.
  • 6. Kazama H, Hamashima H, Sasatsu M, Arai T. Distribution of the antiseptic-resistance gene qacEΔ1 in Gram-positive bacteria. FEMS Microbiol Lett 1998; 165: 295-99.
  • 7. Lewis K. Multidrug resistance: versatile drug sensor of bacterial cells. Curr Biol 1999; 9: R403-R407.
  • 8. Littlejohn TG, Paulsen IT, Gillepsie MT i inni. Substrate specificity and energetics of antiseptic and disinfectant resistance in Staphylococcus aureus. FEMS Microbiol Lett 1992; 95: 259-66.
  • 9. McDonnel G, Russell AD. Antiseptics and disinfectants: activity, action and resistance. Clin Microbiol Rev 1999; 12: 147-79
  • 10. Mitchell BA, Paulsen IT, Brown MH, Skurray RA. Bioenergetics of the Staphylococcal multidrug export protein QacA. J Biol Chem, 1999; 274: 3541-48.
  • 11. Młynarczyk A, Młynarczyk G, Jeljaszewicz J. The genome of Staphylococcus aureus: a review. Zentbl Bakteriol 1998; 287: 277-314.
  • 12. National Commiltee for Clinical Laboratory Standards. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically. M7-A3. NCCLS, Wayne, Pa 1998.
  • 13. Noguchi N, Hase M, Kitta M i inni. Antiseptic susceptibility and distribution of antiseptic-resistance genes in methicillin-resistant Staphylococcus aureus. FEMS Microbiol Lett 1999; 172: 247-53.
  • 14. Pao S S, Paulsen IT Saier MH Jr. Major facilitator superfamily. Microbiol Mol Biol Rev 1998; 62: 1-34.
  • 15. PauIsen IT, Brown MH, Littlejohn TG i inni. Multidrug resistance proteins QacA and QacB from Staphylococcus aureus; Membrane topology and identification of residues involved in substrate specificity. Proc Natl Acad Sci 1996; 93: 3630-35.
  • 16. Russell A D, Maillard J –Y, Furr JR. Possible link between bacterial resistance and use of antibiotics and biocides. Antimicrob Agents Chemother 1998; 42; 2151.
  • 17. Stefańska J. Substancje czynne środków dezynfekcyjnych - mechanizmy działania, oporność drobnoustrojów. Mikrobiol Med 2000; 1: 17-24.
  • 18. Van Bambeke F, Balzi E, Tulkens PM. Antibiotics efflux pumps. Biochem Pharmacol 2000; 60: 457-70.
  • 19. Yamamoto T, Tamara Y, Yokota T. Antiseptic and antibiotic resistance plasmid in Staphylococcus aureus that possesses ability to confer chlorhexidine and acrinol resistance. Antimicrob Agents Chemother 1988; 32: 932-93.
  • 20. Zheleznova EE, Markham P, Edgar R, Bibi E i inni. A structure-based mechanism for drug binding by multidrug transporters. TIBS 2000; 2: 39-43.

Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

bwmeta1.element.agro-article-3f5f5e7f-0bc0-42bd-a488-6f948ab702cd
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