Wplyw zearalenonu i destruktora zearalenonowego na morfologie ukladu pokarmowego swin

• Autorzy: Zielonka L , Polak M. , Otrocka-Domagala I. , Gajecka M. , Obremski K. , Luczynski M.K. , Gora M. , Rotkiewicz T. , Gajecki M.

Warianty tytułu

EN

Impact of zearalenone and zearalenone destructor on the morphology of the digestive system in pigs

• Języki publikacji: PL

Abstrakty

EN

The aim of the study was to determine the impact of feed supplemented with specific amounts of zearalenone and chemical destructor (sodium carbonate) being under research on morphology of the selected organs of the gastrointestinal tract in pigs. The conducted research showed that zearalenone (ZEA) damaged the mucous membrane of the stomach, the small intestines and hepatocytes. The addition of sodium carbonate decreases the intensification of the lesions within the gastrointestinal tract, though it does not eliminate them. The administration of the xenobiotic by itself did not impair the gastrointestinal tract in pigs. Hence it may be useful as a prophylactic tool in the prevention of zearalenone mycotoxicosis

Słowa kluczowe

PL

badania histopatologiczne; pasze; zearalenon; zywienie zwierzat; trzoda chlewna; destruktor zearalenonowy; morfologia; mikotoksyny; uklad pokarmowy; detoksykacja; zanieczyszczenia pasz; weglan sodu

• Wydawca: -
• Czasopismo: Medycyna Weterynaryjna
• Rocznik: 2007
• Tom: 63
• Numer: 05
• Opis fizyczny: s.590-594,fot.,tab.,bibliogr.

Twórcy

autor

Zielonka L

• Uniwersytet Warminsko-Mazurski w Olsztynie, ul.Oczapowskiego 2, 10-718 Olsztyn

autor

Polak M.

autor

Otrocka-Domagala I.

autor

Gajecka M.

autor

Obremski K.

autor

Luczynski M.K.

autor

Gora M.

autor

Rotkiewicz T.

autor

Gajecki M.

Bibliografia

• 1.Abid-Essefi S., Ouanes Z., Hassen W., Baudrimont I., Creppy E., Bacha H.: Cytotoxicity, inhibition of DNA and protein syntheses and oxidative damage in cultured cells exposed to zearalenone. Toxicol. In Vitro 2004, 18, 467-474.
• 2.Avantaggiato G., Havenaar R., Visconti A.: Assessing the zearalenone-binding activity of adsorbent materials during passage through a dynamic in vitro gastrointestinal model. Food Chem. Toxicol. 2003, 41, 1283-1290.
• 3.Bata Á., Lásztity L.: Detoxification of mycotoxin contaminated food and feed by microorganisms. Trends Food Sci. Technol. 1999, 10, 223-228.
• 4.Bouhet S., Oswald I. P.: The effects of micotoxins, fungal food contaminants, on the intestinal epithelial cell-derived innate immune response. Vet. Immunol. Immunop. 2005, 108, 199-209.
• 5.Bovee T. F. H., Helsdingen R. J. R., Rietjens I. M. C. M., Keijer J., Hoogenboom R. L. A. P.: Rapid yeast estrogen bioassays stably expressing human estrogen receptors a and b, and green fluorescent protein: a comparison of different compounds with both receptor types. J. Steroid Biochem. Mol. Biol. 2004, 91, 99-109.
• 6.Brown T., Rottinghaus G., Williams M.: Fumonisin micotoxicosis in broilers: performances and pathology. Avian Dis. 1992, 36, 450-454.
• 7.Campbell-Thompson M., Lynch I. J., Bhardwaj B.: Expression of estrogen receptor (ER) subtypes and ER beta isoforms in colon cancer. Cancer Res. 2001, 61, 632-640.
• 8.Èonková E., Laciaková A., Kováè G., Seidel H.: Fusarial toxins and their role in animal diseases. Vet. J. 2003, 165, 214-220.
• 9.Díaz M., Ramírez C. M., Marin R., Marrero-Alonso J., Gómez T., Alonso R.: Acute relaxatio of mouse duodenum by estrogens: Evidence for an estrogen receptor-independent modulation of muscle excitability. Eur. J. Pharmacol. 2004, 501, 161-178.
• 10.Gajêcki M.: Zearalenone undesirable substances in feed. Pol. J. Vet. Sci. 2002, 5(2), 117-122.
• 11.Góra M., £uczyñski M. K., Smoczyñski L., Gajêcki M., Obremski K., Baranowski M., Zielonka £.: Blocking of zearalenone toxic activity in animal feed in vitro. Chemistry for Agriculture 2004, 5, 278-284.
• 12.Góra M., £uczyñski M. K., Smoczyñski L., Obremski K., Polak M., Œwist M., Zielonka £., Gajêcki M.: Modification of zearalenone structure in model and natural conditions. Pol. J. Vet. Sci. 2004, 7, 181-185.
• 13.Grajewski J., Twarużek M.: Feed supplements limiting animal product pollution by mycotoxins. Pasze Przem. 2000, 10, 11-16.
• 14.Hoffmann B., Schuler G.: Receptor blockers general aspects with respect to their use in domestic animal reproduction. Anim. Reprod. Sci. 2000, 60-61, 295-312.
• 15.Kawano N., Koji T., Hishikawa Y., Murase K., Murata I., Kohno S.: Identification and localization of estrogen receptor a- and b- positive cells in adult male and female mouse intestine at various estrogen levels. Histochem. Cell Biol. 2004, 121, 399-405.
• 16.Lee S. C., Beery J. T., Chu F. S.: Immunohistochemical fate of ochratoxin A in mice. Toxicol. Appl. Pharmacol. 1984, 72, 218-227.
• 17.Malyala A., Kelly M. J., Rønnekleiv O. K.: Estrogen modulation of hypothalamic neurons: Activation of multiple signaling pathways and gene expression changes. Steroids 2005, 70, 397-406.
• 18.Nadal A., Alonso-Magdalena P., Ripoll C., Fuentes E.: Disentangling the molecular mechanisms of action of endogenous and environmental estrogens. Pflugers Arch. Eur. J. Physiol. 2005, 449, 335-343.
• 19.Onji Y., Aoki Y., Tani N., Umebayashi K., Kitada Y., Dohi Y.: Direct analysis of several Fusarium mycotoxins in cereals by capillary gas chromatography-mass spectrometry. J. Chromatogr. A 1998, 815, 59-65.
• 20.Park D. L.: Perspectives on mycotoxin decontamination procedures. Food Addit. Contam. 1993, 10, 49-60.
• 21.Shao L., Serrano D., Mayer L.: The role of epithelial cells in immune regulation in the gut. Semin. Immunol. 2001, 13, 163-176.
• 22.Singh S., Poulsom R., Hanby A. M., Rogers L. A., Wright N. A., Sheppard M. C., Langman M. J.: Expression of oestrogen receptor and oestrogen-inducible genes pS2 and ERD5 in large bowel mucosa and cancer. J. Pathol. 1998, 184, 153-160.
• 23.Słomczyñska M.: The effect of phytoestrogens on the reproductive tract. Pol. J. Vet. Sci. 2004, 7, 223-226.
• 24.Stahl S., Chun T. Y., Gray W. G.: Phytoestrogens act as estrogen agonists in an estrogen-responsive pituitary cell line. Toxicol. Appl. Pharm. 1998, 152, 41-48.
• 25.Vasudevan N., Kow L. M., Pfaff D.: Integration of steroid hormone initiated membrane action to genomic function in the brain. Steroids 2005, 70, 388-396.
• 26.Visconti A., Pascale M.: Determination of zearalenone in corn by means of immunoaffinity clean-up and high-performance liquid chromatography with fluorescence detection. J. Chromatogr. 1998, 815, 133-140.