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2008 | 64 | 11 |

Tytuł artykułu

Grelina i motylina - podobienstwa i roznice w regulacji aktywnosci motorycznej przewodu pokarmowego

Warianty tytułu

EN
Ghrelin and motilin in the regulation of gastrointestinal motor activity

Języki publikacji

PL

Abstrakty

EN
Ghrelin and motilin were compared with regards to their effects on gastrointestinal motility. The structure of their molecules is not very different and they act via similar receptors. Both induce phase three of MMC and enhance contractions during the interdigestive state. Their action can occur via central or peripheral mechanisms, mostly as neuropeptides, although direct action on smooth muscles cannot be excluded. However, the spectrum of ghrelin action is broader and also comprises the digestive period. The role of ghrelin in the gastrointestinal tract is substantial and its action seems to be physiological. Ghrelin is a new hormone-candidate in the gut.

Wydawca

-

Rocznik

Tom

64

Numer

11

Opis fizyczny

s.1283-1286,rys.,bibliogr.

Twórcy

autor
  • Uniwersytet Przyrodniczy we Wroclawiu, ul.Norwida 31, 50-375 Wroclaw

Bibliografia

  • 1.Ariga H., Tsukamoto K., Chen C., Manyth C., Pappas T. N., Takahashi T.: Endogenous acyl ghrelin is involved in mediating spontaneous phase III-like contractions of the rat stomach. Neurogastroenterol. Motil. 2007, 19, 675-680.
  • 2.Asakawa A., Inui A., Kaga T., Yuzuriha H., Nagata T., Ueno N., Makino S., Fujimiya M., Niijima A., Fujino M. A., Kasuga M.: Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin. Gastroenterology 2001, 120, 337-345.
  • 3.Bassi A. K., Häglund Y., Brown J., Rudholm T., Hellström P. M., Näslund E., Lee K., Sanger G. J.: Little or no ability of obestatin to interact with ghrelin or modify motility in the rat gastrointestinal tract. Br. J. Pharmacol. 2007, 150, 58-64.
  • 4.Blom W. A., Lluch A., Vinoy S., Stafleu A., Van Der Berg R., Holst J. J., Kok F. J., Hendriks H. F.: Effect of gastric emptying on the postprandial ghrelin response. Am. J. Physiol. 2005, 290, E399-E395.
  • 5.Camiña J. P.: Cell biology of the ghrelin receptor. J. Neuroendocrinol. 2006, 18, 65-76.
  • 6.Chen C. Y., Inui A., Asakawa A., Fujino K., Kato I., Chen C. C., Ueno N., Fujimiya M.: Des-acyl ghrelin acts by CRF type 2 receptors to disrupt fasted stomach motility in conscious rats. Gastroenterology 2005, 129, 8-25.
  • 7.Dass N. B., Hill J., Muir A., Testa T., Wise A., Sanger G. J.: The rabbit motilin receptor: molecular characterisation and pharmacology. Br. J. Pharmacol. 2003, 140, 948-954.
  • 8.De Smet B., Depoortere I., Moechars D., Swennen Q., Moreaux B., Cryns K., Tack J., Buyse J., Coulie B., Peeters T. L.: Energy homeostasis and gastric emptying in ghrelin knockout mice. J. Pharmacol. Exp. Ther. 2006, 316, 431-439.
  • 9.Depoortere I., Thijs T., Thielemans L., Robberecht P., Peeters T. L.: Interaction of the growth hormone-releasing peptides ghrelin and growth hormone-releasing peptide-6 with the motilin receptor in the rabbit gastric antrum. J. Pharmacol. Exp. Ther. 2003, 305, 660-667.
  • 10.Edholm T., Levin F., Hellström P. M., Schmidt P. T.: Ghrelin stimulates motility in the small intestine of rats through intrinsic cholinergic neurons. Reg. Pept. 2004, 121, 25-30.
  • 11.Fujino K., Inui A., Asakawa A., Kihara N., Fujimura M., Fujimiya M.: Ghrelin induces fasted motor activity of the gastrointestinal tract in conscious fed rats. J. Physiol. (Lond.) 2003, 550, 227-240.
  • 12.He J., Irwin D. M., Zhang Y. P.: Insight into the evolution of the motilin/ghrelin-associated family and their receptors. Miol. Biol. Evol. 2007 (w druku).
  • 13.Inui A., Asakawa A., Bowers C. Y., Mantovani G., Laviano A., Meguid M. M., Fujimiya M.: Ghrelin, appetite, and gastric motility: the emerging role of the stomach as an endocrine organ. FASEB J 2004, 18, 439-456.
  • 14.Kitazawa T., De Smet B., Verbeke K., Depoortere I., Peeters T. L.: Gastric motor effects of peptide and non-peptide ghrelin agonist in mice in vivo and in vitro. Gut 2005, 54, 1078-1084.
  • 15.Levin F., Eedholm T., Schmidt P. T., Gryback P., Jacobsson H., Degerblad M., Hoybye C., Holst J. J., Rehfeld J. F., Hellström P. M., Naslund E.: Ghrelin stimulates gastric emptying and hunger in normal weight humans. J. Clin. Endocrinol. Metabol. 2006, 91, 3296-3302.
  • 16.Luiking Y. C., Akkermans L. M., Peeters T. L., Cnossen P. J., Nieuwenhuijs V. B., Van Berge-Henegouwen G. P.: Effects of motilin on human interdigestive gastrointestinal and gallbladder motility, and involvement of 5HT3 receptors. Neurogastroenterol. Motil. 2002, 14, 151-159.
  • 17.Luiking Y. C., Akkermans L. M., Van Der Reijden A. C., Peeters T. L., Van Berge-Henegouwen G. P.: Differential effects of motilin on interdigestive motility of the human gastric antrum, pylorus, small intestine and gallbladder. Neurogastroenterol. Motil. 2003, 15, 103-111.
  • 18.Murray C. D. R., Martin N. M., Patterson M., Taylor S. A., Ghatei M. A., Kamm M. A., Johnston C., Bloom S. R, Emmanuel A. V.: Ghrelin enhances gastric emptying in diabetic gastroparesis: a double blind, placebo controlled, crossover study. Gut 2005, 54, 1693-1698.
  • 19.Ohno T., Kamiyama Y., Aihara R., Nakabayashi T., Mochiki E., Asao T., Kuwano H.: Ghrelin does not stimulate gastrointestinal motility and gastric emptying: an experimental study of conscious dogs. Neurogastroenterol. Motil. 2006, 18, 129-135.
  • 20.Ohshiro H., Nonaka M., Ichikawa K.: Molecular identification and characterization of the dog motilin receptor. Regul. Pept. 2007 (w druku).
  • 21.Peeters T. L.: Ghrelin: a new player in the control of gastrointestinal functions. Gut 2005, 54, 1638-1649.
  • 22.Pietrzak P., Kotunia A., Godlewski M. M., Zabielski R.: Wpływ greliny na przewód pokarmowy. Przegl. Gastroenterol. 2007, 2, 185-191.
  • 23.Schmidt P. T., Degerblad M., Lindström E., Sundqvist M., Näslund E., Gillberg P. G., Husebye E., Theodorsson E., Hellström P. M.: Circulating ghrelin levels after food intake during different phases of the migrating motor complex in man. Eur. J. Clin. Invest. 2006, 36, 503-508.
  • 24.Tack J., Depoortere I., Bisschops R., Delportere C., Coulie B., Meulemans A., Janssens J., Peeters T.: Influence of ghrelin on interdigestive gastrointestinal motility in humans. Gut 2006, 55, 327-333.
  • 25.Thielemans L., Depoortere I., Vanden Broeck J., Peeters T. L.: The motilin pharmacophore in CHO cells expressing the human motilin receptor. Biochem. Biophys. Res. Commun. 2002, 293, 1223-1227.
  • 26.Tomasetto C., Karam S. M., Ribieras S., Masson R., Lefebvre O., Staub A., Alexander G., Chenard M. P., Rio M. C.: Identification and characterization of a novel gastric peptide hormone: the motilin-related peptide. Gastroenterology 2000, 119, 395-405.
  • 27.Tritos N. A., Kokkotou E. G.: The physiology and potential clinical applications of ghrelin, a novel peptide hormone. Mayo Clin. Proc. 2006, 81, 653-660.
  • 28.Trudel L., Bouin M., Tomasetto C., Eberling P., St-Pierre S., Bannon P., L'Heureux M. C., Poitras P.: Two new peptides to improve post-operative gastric ileus in dog. Peptides 2003, 24, 531-534.
  • 29.Trudel L., Tomasetto C., Rio M. C., Bouin M., Plourde V., Eberling P., Poitras P.: Ghrelin/motilin-related peptide is a potent prokinetic to reverse gastric postoperative ileus in rat. Am. J. Physiol. 2002, 282, G948-G952.
  • 30.Wang Y., Dong L., Cheng Y., Zhao P.: Effects of ghrelin on feeding regulation and interdigestive migrating complex in rats. Scand. J. Gastroenterol. 2007, 42, 447-453.
  • 31.Xu L., Depoortere I., Tomasetto C., Zandecki M., Tang M., Timmermans J. P., Peeters T. L.: Evidence for the presence of motilin, ghrelin, and the motilin and ghrelin receptor in neurons of the myenteric plexus. Reg. Pept. 2005, 124, 119-125.
  • 32.Yin J., Chen J.: Inhibitory effects of gastric electrical stimulation on ghrelin-induced exciatory effects on gastric motility and food intake in dogs. Scand. J. Gastroenterol. 2006, 41, 903-909.

Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

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