Plasma membrane Ca2plus -ATPase in excitable and nonexcitable cells

• Autorzy: Zylinska L. , Soszynski M.
• Języki publikacji: EN

Abstrakty

EN

There is a significant number of data confirming that the maintenance of calcium homeostasis in a living cell is a complex, multiregulated process. Calcium efflux from excitable cells (i.e., neurons) occurs through two main systems an electrochemically driven Na+/Ca2+ exchanger with a low Ca2+ affinity (K0.5 = 10-15 µM), and a plasmalemmal, specific Ca2+-ATPase, with a high Ca2+ affinity (K0.5 <0.5-1 µM), whereas in nonexcitable cells (i.e., erythrocytes) the calcium pump is the sole system responsible for the extrusion of calcium ions. The plasma membrane Ca2+-ATPase (PMCA) is a ubiquitously expressed protein, and more than 26 transcripts of four PMCA genes are distributed in a tissue specific manner. Differences in the structure and localization of PMCA variants are thought to correlate with specific regulatory properties and may have consequences for proper cellular Ca2+ signaling. The regulatory mechanisms of calcium pump activity have been studied extensively, resulting in a new view of the functioning of this important molecule in the membranes.

Słowa kluczowe

EN

calcium homeostasis; plasma membrane; cell; brain; erythrocyte; ATPase; excitable cell; calcium ion; non-excitable cell

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2000
• Tom: 47
• Numer: 3
• Opis fizyczny: p.529-539

Twórcy

autor

Zylinska L.

• Medical University, W.Lindleya 6, 90-131 Lodz, Poland

autor

Soszynski M.

Bibliografia

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