Serine proteinase inhibitors from insect hemolymph

• Autorzy: Polanowski A. , Wilusz T.
• Języki publikacji: EN

Abstrakty

EN

Insect hemolymph, like vertebrate serum, contains several different types of polypeptides that are able to inhibit the catalytic function of proteolytic enzymes, however studies on proteins possessing this capability have been limited to a rela­tively few species. A comparative examination of the inhibition of trypsin, chymo- trypsin, neutrophil elastase and cathepsin G and pancreatic elastase by the hemo­lymph of 14 insect species belonging to six orders showed great diversity in terms of both total proteinase inhibitory capacity and specificity. Most of the inhibitors exa­mined fall into two groups: low molecular mass proteins (below 10 kDa) related to Kunitz type inhibitors, and proteins of about 45 kDa which belong to the serpin superfamily of serine proteinase inhibitors. This minireview describes the properties, characteristics and possible biological significance of selected inhibitors.

Słowa kluczowe

EN

serine proteinase; chymotrypsin; insect hemolymph; inhibitor; hemolymph

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 1996
• Tom: 43
• Numer: 3
• Opis fizyczny: p.445-453

Twórcy

autor

Polanowski A.

• University of Wroclaw, Tamka 2, 50-137 Wroclaw, Poland

autor

Wilusz T.

Bibliografia

• 1. Laskowski, M. & Kato, I. (1980) Protein inhibitors of proteinases. Ann. Rev. Biochem. 49, 593-626.
• 2. Heimburger, N. (1975) Proteinase inhibitors of % human plasma. Their properties and control functions; in Proteases and Biological Control (Reich, E., Rifkin, D.B. & Shaw, E., eds.) pp. 367-386, Cold Spring Harbor Laboratories, N.Y.
• 3. Travis, J. & Salvesen, G.S. (1983) Human plasma proteinase inhibitors. Attttu. Rev. Biochem. 52, 655-709.
• 4. Troll, W. & Kennedy, A.R. (1989) Protease inhi­bitors as cancer chemopreventive agents. Cancer Res. 49,499-502.
• 5. McKeehan, W.L., Sakagami, Y., Hoshi, H. & Mc- Keehan, K.A. (1986) Two apparent endothelial cell growth factors from human hepatoma cells are tumor-associated proteinase inhibitors. J. Biol. Chem. 261,5378-5383.
• 6. Popik, W., Inglot, A.D., Wilusz, T. & Polanowski, A. (1988) Participation of polypeptide prote­inase inhibitors in proliferation of fibroblast. Arch. Immunol. Therap. Expt. 36,645-653.
• 7. Eguchi, M. (1993) Protein protease inhibitors in insects and comparison with mammalian inhi­bitors. Comp. Biochem. Physiol. 105B, 449-456.
• 8. Kuiera, M., Sehnal, F. & Mala, J. (1984) Effect of developmental dearrangements on the pro­teolytic and protease inhibitory activities in Galleria mellonella (Insecta). Comp. Biochem. Physiol. 79B, 255-261.
• 9. Eguchi, M., Matsui, Y. & Matsumoto, T. (1986) Developmental change and hormonal control of chymotrypsin inhibitors in the haemolymph of the silkworm, Bombyx mori. Comp. Biochem. Physiol. 84B, 327-332.
• 10. Aratake, H., Deng, L.R. Fuji, H., Kawaguchi, Y. & Koga, K. (1990) Chymotrypsin inhibitors in haemolymph and eggs of the silkworm, Bombyx mori: Developmental changes in inhibitory activity. Comp. Biochem. Physiol. 97A, 205-209.
• 11. Polanowski, A., Wilusz, T., Blum, M.S., Escou- bas, P., Schmidt, J.O. & Travis, J. (1992) Serine proteinase inhibitor profile in the hemolymph of a wide range of insect species. Comp. Biochem. Physiol. 102B, 757-760.
• 12. Schultz, H., Mohr, M. & Meyer, M. (1989) Elastase and papain inhibition by serum of mammals. Scand.}. Clin. Lab. Invest. 49,381-388.
• 13. Laskowski, M., Kato, 1., Ardelt, W., Cook, J., Denton, A., F.mpie, M.W., Kohr, W.J., Park, S.J., Schatzley, B.L., Schoenberger, O.L., Tashiro, M., Vichot, G., What ley, H.E., Wieczorek, A. & Wieczorek, M. (1987) Ovomucoid third domains from 100 avian species: isolation, sequences, and hyper-variability of enzyme-inhibitor contact residues. Biochemistry 26, 202-221.
• 14. Carrell, R.W. & Boswell, D.R. (1986) Serpins: The superfamily of plasma serine proteinase inhibitors; in Proteinase Inhibitors (Barrett, A.J. & Salvesen, G.S., eds.) pp. 403-420, Elsevier, N.Y.
• 15. Kanost, M.R. Prasad, S.V. & Wells, M.A. (1989) Primary structure of a member of the serpin superfamily of proteinase inhibitors from an insect, Manduca sexta. J. Biol. Chem. 264,965-972.
• 16. Kanost, M.R. (1990) Isolation and characte­rization of four serine proteinase inhibitors (serpins) from hemolymph of Manduca sexta. Insect Biochem. 20,141-147.
• 17. Sasaki, T. & Kabayashi, K. (1984) Isolation of two novel proteinase inhibitors from hemolymph of silkworm larva, Bombyx mori. Comparison with human serum proteinase inhibitors. J. Biochem. 95,1009-1017.
• 18. Tagaki, H., Narumi, H., Nakamura, K. & Sasaki, T. (1990) Amino acid sequence of silkworm (Bombyx mori) hemolymph antitrypsin deduced from its homology with serpins. J. Biochem. 108, 372-378.
• 19. Narumi, H., Hishida, T., Sasaki, T., Feng, D.F. & Doolittle, R.F. (1993) Molecular cloning of silkworm (Bombyx mori) antichymotrypsin. A new member of the serpin superfamily of proteins from insect. Eur. /. Biochem. 214, 181-187.
• 20. Sasaki, T. (1991) Patchwork-structure serpins from silkworm (Bombyx mori) larval hemo­lymph. Eur. J. Biochem. 202, 255-261.
• 21. Eguchi, M. & Shomoto, K. (1985) Purification and properties of a chymotrypsin inhibitors from hemolymph of the silkworm. Comp. Biochem. Physiol. 81B, 301-307.
• 22. Ramesh, N., Sugumaran, M. & Mole, J.E. (1988) Purification and characterization of two trypsin inhibitors from the hemolymph of Manduca sexta larvae. J. Biol. Chem. 263,11523-11527.
• 23. Sasaki, T. (1978) Chymotrypsin inhibitors from hemolymph of the silkworm, Bomlryx mori. /. Biol. Chem. 84,267-276.
• 24. Sasaki, T. (1984) Amino acid sequence of a novel Kunitz-type chymotrypsin inhibitor from hemolymph of silkworm larvae, Bombyx mori. iF.BS Lett. 168,227-230.
• 25. Sasaki, T. (1988) Amino-acid sequences of two basic chymotrypsin inhibitors from silkworm larval hemolymph. Biol. Chem. Hoppe-Seyler 369, 1235-1241.
• 26. Boigegrain, R.-A., Mattras, H., Brehelin, M., Paroutaud, P. & Coletti-Previero, M.-A. (1992) Insect immunity: Two proteinase inhibitors from hemolymph of Locusta migratoria. Biochim. Biophys. Res. Commun. 189.790-793.
• 27. Kellenberger, C., Boudier, C., Bermudez, I., Bieth, J.G., Luu, B. & Hietter, H. (1995) Serine proteinase inhibition by insect peptides con­taining a cysteine knot and a triple-stranded £-sheeL J. Biol. Chem. 270,25514-25519.
• 28. Sugumaran, M., Saul, S.J. & Ramesh, N. (1985) Endogenous protease inhibitors prevent un- desired activation of propherolase in insect hemolymph. Biochim. Biophys. Res. Commun. 132,1124-1129.
• 29. Papayannopoulos, l.A. & Biemann, K. (1992) Amino acid sequence of a protease inhibitor isolated from Sarcophaga bulla ta detemined by mass spectrometry. Protein Sci. 1,278-288.
• 30. Polanowski, A., Wilusz, T., Blum, M.S. & Travis, J. (1994) Two serine proteinase inhibitors from the larval hemolymph of Heliothis zea. Acta Biochim. Polon. 41,178-180.
• 31. Eguchi, M., Itoh, M., Nishino, K., Shibata, H., Tenaka, T., Kamei-I Iayashi, K. & Hara, S. (1994) Amino acid sequence of an inhibitor from the silkworm (Bombyx morí) hemolymph against fungal protease.). Biochem. 115,881-884.
• 32. Pham, T.-N., I iayashi, K., Takano, R., Itoh, M., Eguchi, M., Shibata, H., Tanaka, T. & liara, S. (1996) A new family of serine proteinase inhi­bitors (Bombyx mori) as established from the unique topological relation between the posi­tions of disulfide bridges and reactive site. /. Biochem. 119, 428-434.
• 33. Fuji, H., Aratake, H., Deng, L.R., Nakamura, M., Kawaguchi, V. & Sagakuchi, B. (1989) Puri­fication and characterization of a novel chymotrypsin inhibitor controlled by the chymotrypsin inhibitor A Uct-A) gene from the larval hemolymph of the silkworm, Bombyx morí. Comp. Biochem. Physiol. 94B, 149-155.
• 34. St Leger, R.J., Durrands, P.K., Charnley, A.K. & Cooper, R.M. (1988) Role of extracellular chymoelastase in the virulence of Metharisium anisopliae for Manduca sexta. J. Invertebr. Path. 52, 285-293.
• 35. Jiang, H., Mulnix, A.B. & Kanost, M.R. (1995) Expression and characterization of recombinant Manduca sexta serpin-lB and site-directed mu­tants that change its inhibitory selectivity. Insect Biochem. Molec. Biol. 25,1093-1100.
• 36. Eguchi, M., Haneda, I. & Iwamoto, A. (1982) Properties of protease inhibitors from the hae- molyph of silkworms, Bombyx mori, Antheraea pernyi and Philosamia cynthia ricini. Comp. Biochem. Physiol. 71B, 569-576.
• 37. Boucias, D.G. & Pendland, J.C. (1987) Detection of protease inhibitors in the hemolymph of resistant Anticarsia gemmatalis which are inhi­bitory to the entomopathogenic fungus, Nomu- raea rileyi. Experientia 43,336-339.
• 38. Kanost, M.R. (1990) Serine proteinase inhibitors from the serpin gene family in Manduca sexta and Drosophila melanogaster; in Molecular Insect Science (Hagedorn, H.H., Hildebrand, J.G., Kidwell, M.G. & Law, J.H., eds.) pp. 139-146, Plenum, New York.
• 39. Ashida, M. & Yamazaki, H.I. (1990) Bio­chemistry of the phenoloxidase system in insects: with special references to its activation; in Molting and Metamorphosis (Ohnishi, E. & Ishizaki, H., eds.) pp. 239-265, Japan Sci. Soc. Press, Tokyo/Springer Verlag, Berlin.
• 40. Ashida, M. & Sasaki, T. (1994) A target protease activity of serpins in insect hemolymph. Insect Biochem. Molec. Biol. 24,1037-1041.
• 41. Ashida, M. & Dohke, K. (1980) Activation of pre-phenoloxidase from the hemolymph of the silkworm, Bombyx mori. Insect Biochem. 10, 37-47.
• 42. Yoshida, H. & Ashida, M. (1986) Microbial acti­vation of two serine enzymes and prophenol- oxidase in the plasma fraction of hemolymph of the silkworm, Bombyx mori. Insect Biochem. 16, 539-545.