The flavonoids, quercetin and isorhamnetin 3-O-acylglucosides diminish neutrophil oxidative metabolism and lipid peroxidation

• Autorzy: Zielinska M. , Kostrzewa A. , Ignatowicz E. , Budzianowski J.
• Języki publikacji: EN

Abstrakty

EN

Two natural flavonoids, quercetin and isorhamnetin 3-O-acylglucosides, were examined for their inhibitory influence on the in vitro production and release of reactive oxygen spe­cies in polymorphonuclear neutrophils (PMNs). The generation of superoxide radical, hy­drogen peroxide and hypochlorous acid were measured by, respectively, cytochrome c re­duction, dichlorofluorescin oxidation and taurine chlorination. Membrane lipid oxidation was studied by the thiobarbituric acid method in mouse spleen microsomes. The addition of flavonoids at the concentration range 1-100 uM inhibited PMNs oxidative metabolism and lipid peroxidation in a dose-dependent manner. The results suggest that these flavonoids suppress the oxidative burst of PMNs and protect membranes against lipid peroxidation.

Słowa kluczowe

EN

isorhamnetin 3-O-acylglucoside; flavonoids; oxidative metabolism; polymorphonuclear neutrophil; respiratory burst; reactive oxygen species; flow cytometry; quercetin; lipid peroxidation

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2001
• Tom: 48
• Numer: 1
• Opis fizyczny: p.183-189,fig.

Twórcy

autor

Zielinska M.

• Karol Marcinkowski University of Medical Sciences, Grunwaldzka 6, 60-780 Poznan, Poland

autor

Kostrzewa A.

autor

Ignatowicz E.

autor

Budzianowski J.

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