Amphetamine enhances natural killer cytotoxic activity via beta-adrenergic mechanism

• Autorzy: Glac W. , Borman A. , Badtke P. , Stojek W. , Orlikowska A. , Tokarski J.
• Języki publikacji: EN

Abstrakty

EN

Although addiction to amphetamine (AMPH) is a serious social and medical problem, the data concerning AMPH – immune interactions are still not numerous. To analyze the mechanism of AMPH-induced changes in the function of the immune system, rats were pretreated with ß-adrenergic receptor antagonist propranolol (PROP; 5 mg/kg, i.p.) prior to AMPH (1 mg/kg, i.p.) administration. Natural Killer cells cytotoxicity (NKCC) (51Cr-release assay), the number of LGLs (NK cells) (Timonen method), leukocytes, lymphocytes and monocytes, and plasma corticosterone level (CORT) (RIA) were evaluated in the peripheral blood and spleen. In the peripheral blood increases in NKCC (+331%), as well as in LGL (+33%) and monocyte (+65%) number observed after AMPH were partially inhibited by PROP (respectively by 30%, 19%, and 30%) in contrast to lymphopenia (-19%) and granulocytosis (+65%) which were not affected by ß-blockade. In the spleen AMPH-induced decreases in NKCC (-25%) and in all the leukocyte populations number (approximately -30%) were completely blocked by PROP. Plasma CORT level, highly elevated by AMPH (+337%), was attenuated nearly by 50% under ß-adrenergic blockade. These data indicate that AMPH-induced enhancement of cytotoxic activity of NK cell is related to ß-adrenergic mechanism.

Słowa kluczowe

EN

amphetamine; natural killer; cytotoxic activity; beta-adrenergic mechanism; leucocyte; lymphocyte; monocyte; granular lymphocyte; propranolol; adrenergic system; immune system; peripheral blood; spleen; rat

• Wydawca: -
• Czasopismo: Journal of Physiology and Pharmacology. Supplement
• Rocznik: 2006
• Tom: 57
• Numer: 11
• Opis fizyczny: p.125-132,fig.,ref.

Twórcy

autor

Glac W.

• University of Gdansk, Kladki st. 24, 80-822 Gdansk, Poland

autor

Borman A.

autor

Badtke P.

autor

Stojek W.

autor

Orlikowska A.

autor

Tokarski J.