Chromosomal aberrations in humans induced by benzene

• Autorzy: Holeckova B. , Piesova E. , Sivikova K. , Dianovsky J.
• Języki publikacji: EN

Abstrakty

EN

Adverse effects associated with occupational exposure to benzene have often been reported in humans. It has been shown, that benzene causes chromosomal aberrations, sister chromatid exchanges and micronuclei in lymphocytes of exposed workers. In addition to evidence by conventional cytogenetic methods, the genotoxic effect of benzene has also been proved by a more specific approach based on fluorescence in situ hybridization with DNA probes. In the present paper, the nature of benzene-induced chromosomal aberrations and supposed consequence on human health is reviewed. The new possibilities in chromosomal alterations identification by molecular cytogenetic methods are also presented.

Słowa kluczowe

EN

man; pollutant compound; leukemia; benzene; chromosome aberration; molecular cytogenetics; chronic exposure; high concentration

• Wydawca: -
• Czasopismo: Annals of Agricultural and Environmental Medicine
• Rocznik: 2004
• Tom: 11
• Numer: 2
• Opis fizyczny: p.175-179,ref.

Twórcy

autor

Holeckova B.

• University of Veterinary Medicine, Komenskeho 73, 041 81 Kosice, Slovak Republic

autor

Piesova E.

autor

Sivikova K.

autor

Dianovsky J.

Bibliografia

• 1. Baudouin C, Charveron M, Tarroux R, Gall Y: Environmental pollutants and skin cancer. Cell Biol Toxicol 2002, 18, 341-348.
• 2. Bloemen LJ, Youk A, Bradley TD, Bodner KM, Marsh G: Lympho-haematopoietic cancer risk among chemical workers exposed to benzene. Occup Environ Med 2004, 61, 270-274.
• 3. Bogadi-Sare A, Zavalic M, Turk R: Utility of a routine medical surveillance program with benzene exposed workers. Am J Ind Med 2003, 44, 467-473.
• 4. Bukvic N, Bavaro P, Elia G, Cassano F, Fanelli M, Guanti G: Sister chromatid exchange (SCE) and micronucleus (MN) frequencies in lymphocytes of gasoline station attendants. Mutat Res-Gen Tox En 1998, 415, 25-33.
• 5. Carere A, Antoccia A, Cimini D, Crebelli R, Degrasi F, Leopardi P, Marcon F, Sgura A, Tanzarella C, Zijno A: Genetic effects of petroleum fuels II: Analysis of chromosome loss and hyperploidy in peripheral lymphocytes of gasoline station attendants. Environ Mol Mutagen 1998, 32, 130-138.
• 6. Carletti R, Romano D: Assessing health risk from benzene pollution in an urban area. Environ Monit Assess 2002, 80, 135-148.
• 7. Crossignani P, Tittarelli A, Borgini A, Codazzi T, Rovelli A, Porro E, Contiero P, Bianchi N, Tagliabue G, Fissi R, Rositto F, Berrino F: Childhood leukaemia and road traffic: A population-based case control study. Int J Cancer 2004, 108, 596-599.
• 8. Crane MM, Keating MJ, Trujillo JM, Labarthe DR, Frankowski RF: Environmental exposures in cytogenetically defined subsets of acute nonlymphocytic leukaemia. J Am Med Assoc 1989, 262, 634-639.
• 9. Eastmond DA, Rupa DS, Hasegawa LS: Detection of hyperdiploidy and chromosome breakage in interphase human lymphocytes following exposure to the benzene metabolite hydroquinone using multicolour fluorescence in situ hybridization with DNA probes. Mutat Res 1994, 322, 9-20.
• 10. Eastmond DA, Schuler M, Franz Ch, Chen H, Parks R, Wang L, Hasegawa L: Characterization and mechanisms of chromosomal alterations induced by benzene in mice and humans. Res Rep Health Eff Inst 2001, 103, 1-68; discussion 69-80.
• 11. Glass DC, Gray CN, Jolley DJ, Gibbons C, Sim MR, Frotschi L, Adams GG, Bisby JA, Manuell R: Leukemia risk associated with lowlevel benzene exposure. Epidemiology 2003, 14, 569-577.
• 12. Hrelia P, Maffei F, Angelini S, Forti GC: A molecular epidemiological approach to health risk assessment of urban air pollution. Toxicol Lett 2004, 149, 261-267.
• 13. Chen H, Rupa DS, Tomar R, Eastmond DA: Chromosomal loss and breakage in mouse bone marrow and spleen cells exposed to benzene in vivo. J Cancer Res 1994, 54, 3533-3539.
• 14. Chung HW, Kang SJ, Kim SY: A combination of the micronucleus assay and a FISH technique for evaluation of the genotoxicity of 1,2,4-benzenetriol. Mutat Res 2002, 516, 49-56.
• 15. Chung HW, Kim SY: Detection of chromosome specific aneusomy and translocation by benzene metabolites in human lymphocytes using fluorescence in situ hybridization with DNA probes for chromosome 5, 7, 8 and 21. J Toxicol Environ Health 2002, Part A, 65, 365-372.
• 16. Iturbe R, Flores RM, Flores CR, Torres LG: TPH-contaminated Mexican refinery soil: health risk assessment and the first year of changes. Environ Monit Assess 2004, 91, 237-255.
• 17. Ji Z, Li G, Li L, Gao Y: Chromosome aberration analysis of peripheral lymphocytes in workers exposed to benzene. Wei Sheng Yan Jiu 2004, 33, 269-272.
• 18. Kakazu N, Ashihara E, Hada S, Ueda T, Sasaki H, Terada M, See TA: Development of spectral colour banding in cytogenetic analysis. Lancet 2001, 357, 529-530.
• 19. Kakazu N, Bar-Am I, Hada S, Ago H, Abe T: A new chromosome banding technique, spectral colour banding (SCAN) for full characterization of chromosomal abnormalities. Genes Chromosomes Cancer 2003, 37, 412-416.
• 20. Kasuba V, Rozgaj R, Sentija K: Cytogenetic changes in subjects occupationally exposed to benzene. Chemosphere 2000, 40, 307-310.
• 21. Kim SY, Choi JK, Cho YH, Chung EJ, Paek D, Chung HW: Chromosome aberrations in workers exposed to low levels of benzene: association with genetic polymorphisms. Pharmacogenetics 2004, 14, 453-463.
• 22. Lam TH, Zhu CQ, Jiang CQ: Lymphocyte DNA damage in elevator manufacturing workers in Guangzhou, China. Mutat Res 2002, 15, 145-157.
• 23. Lebailly P, Willett EV, Moorman AV, Roman E, Cartwright R, Morgan GJ, Wild CP: Genetic polymorphisms in microsomal epoxide hydrolase and susceptibility to adult acute myeloid leukaemia with defined cytogenetic abnormalities. Brit J Haematol 2002, 116, 587-594.
• 24. Li X, Zheng LK, Deng LX, Zhang Q: Detection of numerical chromosome aberrations in sperm of workers exposed to benzene series by two-colour fluorescence in situ hybridization. Yi Chuan Xue Bao 2001, 28, 589-594.
• 25. Liu S, Zheng L, Deng L, Tang G, Zhong O: Detection of numerical chromosome aberrations in sperm of workers exposed to benzene series by two-color fluorescence in situ hybridizaion. Zhonghua Yu Fang Yi Xue Za Zhi 2000, 34, 17-19.
• 26. Liu XX, Tang GH, Yuan YX, Deng LX, Zhang Q, Zheng LK: Detection of the frequencies in numerical and structural chromosome aberrations in sperm of benzene series-exposed workers by multi-color fluorescence in situ hybridisation. Yi Chuan Xue Bao 2003, 30, 1177-1182.
• 27. Marcon F, Zijno A, Crebelli R, Carere A, Veidebaum T, Peltonen K, Parks R, Schuler M, Eastmond D: Chromosome damage and aneuploidy detected by interphase multicolour FISH in benzene exposed shale oil workers. Mutat Res 1999, 445, 155-166.
• 28. Marcon F, Zijno A, Dobrowolny G, Carere AS, Crebelli R: Detection of 1cen-1q12 lesions in different phases of cell cycle: dual colour FISH analysis of peripheral lymphocytes from subjects with occupational exposure to petroleum fuels. Mutagenesis 2002, 17, 157-162.
• 29. Mitacek EJ, Brunnemann KD, Polednak AP, Limsila T, Bhothisuwan K, Hummel CF: Rising leukaemia rates in Thailand: the possible role of benzene and related compounds in cigarette smoke. Oncol Rep 2002, 9, 1399-1403.
• 30. Mitelman F, Brandt L, Nilsson PG: Relation among occupational exposure to potential mutagenic/carcinogenic agents, clinical findings, and bone marrow chromosomes in acute nonlymphocytic leukaemia. Blood 1978, 52, 1229-1237.
• 31. Mitelman F, Nilsson PG, Brandt L, Alimena G, Gastaldi R, Dallapiccola B: Chromosome pattern, occupational and clinical features in patients with acute nonlymphocytic leukaemia. Cancer Genet Cytogenet 1981, 4, 197-214.
• 32. Moorman AV, Roman D, Cartwright RA, Morgan GJ, Wild CP: Smoking and the risk of acute myeloid leukaemia in cytogenetic subgroups. Br J Cancer 2002, 86, 60-62.
• 33. Nicholson CA, Fathepure BZ: Biodegradation of benzene by halophilic and halotolerant bacteria under aerobic conditions. Appl Environ Microbiol 2004, 70, 1222-1225.
• 34. Rupa DS, Schuler M, Eastmond DA: Detection of hyperdiploidy and breakage affecting the 1cen-1q12 region of cultured interphase human lymphocytes treated with various genotoxic agents. Environ Mol Mutagen 1997, 29, 161-167.
• 35. Qu Q, Shore R, Li G, Jim X, Chen LC, Cohen B: Validation and evaluation of biomarkers in workers exposed to benzene in China. Res Rep Health Eff Inst 2003, 115, 1-72; discussion 73-87.
• 36. Sasiadek M: Nonrandom distribution of breakpoints in the karyotypes of workers occupationally exposed to benzene. Environ Health Persp 1992, 97, 255-257.
• 37. Sasiadek M, Schlade K, Busza H, Czemarmazovicz H, Stembalska A: Classical and molecular cytogenetic analysis of diepoxybutaneinduced chromosome aberrations. Mutat Res 1998, 419, 155-161.
• 38. Shen YM, Xue YQ, Li JY, Pan JL, Wu JF: Clinical, cytogenetic and dual color FISH studies on five cases of myelodystrophic syndrome or acute myeloid leukaemia patients with 1;7 translocation. Chinese Med J 2003, 116, 231-234.
• 39. Silva MdoC, Gaspar J, Duarte Silva I, Faker A, Rueff J: GSTM 1, GSTT 1 and GSTP 1 genotypes and the genotoxicity of hydroquinone in human lymphocytes. Environ Mol Mutagen 2004, 43, 258-264.
• 40. Smith MT, Zhang L, Wang Y, Hayes RB, Li G, Wiemels J, Dosemeci M, Titenko-Holland N, Xi L, Kolachana P, Yin S, Rothman N: Increased translocations and aneusomy in chromosomes 8 and 21 among workers exposed to benzene. Cancer Res 1998, 58, 2176-2181.
• 41. Smith MT, Skibola CF, Allan JM, Morgan GJ: Causal models of leukaemia and lymphoma. IARC Sci Publ 2004, 157, 373-392.
• 42. Snyder R, Witz G, Goldstein BD: The toxicology of benzene. Environ Health Perspect 1993, 100, 293-306.
• 43. Snyder R: Overview of the toxicology of benzene. J Toxicol Environ Health 2000, Part A, 61, 339-346.
• 44. Sorensen M, Skov H, Autrup H, Hertel O, Loft S: Urban benzene exposure and oxidative DNA damage: influence of genetic polymorphisms in metabolism genes. Sci Total Environ 2003a, 309, 69-80.
• 45. Sorensen M, Autrup H, Moller P, Hertel O, Jensen SS, Vinzents P, Knudsen LE, Loft S: Linking exposure to environmental pollutants with biological effects. Mutat Res 2003b, 544, 255-271.
• 46. Sram RJ, Beskid O, Binkova B, Rossner P, Smerhovsky Z: Cytogenetic analysis using fluorescence in situ hybridisation (FISH) to evaluate occupational exposure to carcinogens. Toxicol Lett 2004, 149, 335-344.
• 47. Stillman WS, Varella-Garcia M, Gruntmeir JJ, Irons R D: The benzene metabolite, hydroquinone, induces dose-dependent hypoploidy in a human cell line. Leukemia 1997, 11, 1540-1545.
• 48. Stillman WS, Varella-Garcia M, Irons RD: The benzene metabolites hydroquinone and catechol act in synergy to induce dosedependent hypoploidy and -5q31 in human cell line. Leuk Lymphoma 1999, 35, 269-281.
• 49. Stillman WS, Varella-Garcia M, Irons RD: The benzene metabolite hydroquinone, selectively induces 5q31- and -7 in human CD34+CD19-bone marrow cells. J Exp Hematol 2000, 28,169-176.
• 50. Stronati L, Farris A, Pacchierotti F: Evaluation of chromosome painting to assess the induction and persistence of chromosome aberrations in bone marrow cells of mice treated with benzene. Mutat Res 2004, 545, 1-9.
• 51. Sul DG, Lee D, Im H, Oh E, Kim J, Lee E: Single strand DNA breaks in T- and B- lymphocytes and granulocytes in workers exposed to benzene. Toxicol Lett 2002, 134, 87-95.
• 52. Subrahmanyam VV, Ross D, Eastmond DA, Smith MT: Potential role of free radicals in benzene-induced myelotoxicity and leukaemia. J Free Radic Biol Med 1991, 11, 495-515.
• 53. Tompa A, Major J, Jakab MG: Monitoring of benzene-exposed workers for genotoxic effects of benzene: improved-working-condition related decrease in the frequencies of chromosomal aberrations in peripheral blood lymphocytes. Mutat Res 1994, 304, 159-165.
• 54. Tucker JD, Lee DA, Ramsey MJ, Briner J, Olsen L, Moore DH: On the frequency of chromosome exchanges in a control population measured by chromosome painting. Mutat Res 1994, 313, 193-202.
• 55. Vermeulen R, Li G, Lam Q, Dosemeci M, Rappaport SM, Bohong X, Smith MT, Zhang L, Haves RB, Linet M, Mu R, Wang L, Xu J, Yin S, Rothman W: Detailed exposure assessment for a molecular epidemiology study of benzene in two shoe factories in China. Ann Occup Hyg 2004, 48, 105-116.
• 56. Xu JN, Wu CL, Chen Y, Wang QK, Li GL, Su Z: Effect of the polymorphism of myeloperoxidase on the risk of benzene poisoning. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2003, 21, 86-89.
• 57. Yaris F, Dikici M, Akbulut T, Yaris E, Sabuncu H: Story of benzene and leukaemia: epidemiologic approach of Muzaffer Aksoy. J Occup Health 2004, 46, 244-247.
• 58. Wan J, Shi J, Hui L, Wu D, Jin X, Zhao N, Huang W, Xia Z, Hu, G: Association of genetic polymorphisms in CYP2E1, MPO, NQ 01, GSTM1 and GSTT1 genes with benzene poisoning. Environ Health Perspect 2002, 110, 1213-1218.
• 59. Whysner J: Benzene-induced genotoxicity. J Toxicol Environ Health 2000, Part A, 61, 347-351.
• 60. Whysner J, Reddy MV, Ross PM, Mohan M, Lax EA: Genotoxicity of benzene and its metabolites. Mutat Res 2004, 566, 99-130.
• 61. Zhang L, Venkatesh P, Creek ML, Smith MT: Detection of 1,2,4-benzenetriol induced aneuploidy and microtubule disruption by fluorescence in situ hybridization and immunocytochemistry. Mutat Res 1994, 320, 315-327.
• 62. Zhang L, Rothman N, Wang Y, Hayes RB, Bechtold W, Venkatesh P, Yin S, Wang Y., Dosemeci M, Li G, Lu W, Smith MT: Interphase cytogenetics of workers exposed to benzene. Environ Health Perspect 1996, 104(Suppl 6), 1325-1329.
• 63. Zhang L, Wang YX, Shang N, Smith MT: Benzene metabolites induce the loss and long arm deletion of chromosomes 5 and 7 in human lymphocytes. Leukemia Res 1998a, 22, 105-113.
• 64. Zhang L, Rothman N, Wang Y, Hayes RB, Li G, Dosemeci M, Yin S, Kolachana P, Titenko-Holland N, Smith MT: Increased aneusomy and long arm deletion of chromosomes 5 and 7 in the lymphocytes of Chinese workers exposed to benzene. Carcinogenesis 1998b, 19, 1955-1961.
• 65. Zhang L, Rothman N, Wang Y, Hayes RB, Yin S, Titenko-Holland N, Dosemeci M, Wang YZ, Kolachana P, Lu WL, Xi L, Li GL, Smith MT: Benzene increases aneuploidy in the lymphocytes of exposed workers: A comparison of data obtained by fluorescence in situ hybridization in interphase and metaphase cells. Environ Mol Mutagen 1999, 34, 260-268.
• 66. Zhang L, Eastmond DA, Smith MT: The nature of chromosomal aberrations detected in humans exposed to benzene. J Crit Rev Toxicol 2002, 32, 1-42.
• 67. Zhu CQ, Lam TH, Jiang CQ: Lymphocyte DNA damage in bus manufacturing workers. Mutat Res 2001, 491, 173-181