The effects of bistramides on rodent malaria

• Autorzy: Gautret P , Le Pape P , Biard J F , Menard D , Verbist J F , Marjolet M
• Języki publikacji: EN

Abstrakty

EN

Bistramide D and K were extracted from a New Caledonian marine colonial ascidian Lissoclinum bistratum and tested against Plasmodium berghei and P. vinckei petteri in mice. Bistramide D was able to reduce parasitaemia by almost 50% in P. berghei infected mice, but the ID₅₀ (>5 mg/kg) was very close to the LD₅₀ (8 mg/kg). In the same assay, bistramide K was less active than bistramide D. The mid-term trophozoite and the old trophozoite were shown to be the stages most sensitive to bistramide D in P. vinckei petteri infected mice. Therefore, bistramides are interesting experimental tools but do not present a major interest as potential antimalarial drugs.

Słowa kluczowe

EN

malaria; chloroquine; infection; bistramide D; mice; Plasmodium berghei; rodent; bistramide; bistramide K; mouse; Lissoclinum bistratum; trophozoite; antimalarial drug

• Wydawca: -
• Czasopismo: Acta Parasitologica
• Rocznik: 1998
• Tom: 43
• Numer: 1
• Opis fizyczny: p.50-53,fig.

Twórcy

autor

Gautret P

• Laboratoire de Parasitologie et de Pathologie Exotique, Faculte de Medicine, 1 rue Gaston Veil 44035 Nantes cedes 01

autor

Le Pape P

• Laboratoire de Parasitologie et d'Organisation Animale, Faculte de Pharmacie, 1 rue Gaston Veil 44035 Nantes cedex 01

autor

Biard J F

• Groupe de Recherche "Substances Marines a Activates Biologiques" (SMAB), ISOMer, Faculte de Pharmacie, 1 rue Gaston Veil 44035 Nantes cedex 01, France

autor

Menard D

• Laboratoire de Parasitologie et de Pathologie Exotique, Faculte de Medicine, 1 rue Gaston Veil 44035 Nantes cedes 01

autor

Verbist J F

• Groupe de Recherche "Substances Marines a Activates Biologiques" (SMAB), ISOMer, Faculte de Pharmacie, 1 rue Gaston Veil 44035 Nantes cedex 01, France

autor

Marjolet M

• Laboratoire de Parasitologie et de Pathologie Exotique, Faculte de Medicine, 1 rue Gaston Veil 44035 Nantes cedes 01

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